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daprodustat,GSK1278863

Product Name
daprodustat,GSK1278863
CAS No.
960539-70-2
Chemical Name
daprodustat,GSK1278863
Synonyms
CS-1541;GSK1278863;Daprodustat;GSK 1278863 NEW;GSK1278863, >98%;Daprodustat, >98%;13C12]-Daprodustat;GSK1278863,daprodustat;daprodustat,GSK1278863;Daprodustat Impurity 3
CBNumber
CB63038532
Molecular Formula
C19H27N3O6
Formula Weight
393.43
MOL File
960539-70-2.mol
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daprodustat,GSK1278863 Property

Melting point:
237-241oC
Density 
1.359±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), DMSO (Slightly)
pka
3.44±0.10(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19915
Product name
Daprodustat
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19915
Product name
Daprodustat
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
19915
Product name
Daprodustat
Purity
≥98%
Packaging
10mg
Price
$261
Updated
2024/03/01
Cayman Chemical
Product number
19915
Product name
Daprodustat
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
TRC
Product number
D193368
Product name
Daprodustat
Packaging
10mg
Price
$90
Updated
2021/12/16
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daprodustat,GSK1278863 Chemical Properties,Usage,Production

Uses

Daprodustat is a novel HIF (Hypoxia inducible factor)-prolyl hydroxylase inhibitor.

Biological Activity

daprodustat (gsk1278863) is a hif-prolyl hydroxylase inhibitor.hypoxia stimulates erythropoietin (epo) release through accumulation of hypoxia-inducible factor 1α (hif-1α), resulting in an increase of erythrocyte production by the bone marrow. hif-prolyl hydroxylase inhibitors have been used to selectively activate the phd-signaling pathway, leading to the stabilization of hifα subunits, which can affect the transcription of hif-responsive genes.

in vitro

in-vitro biotransformation data indicated that gsk1278863 was primarily metabolized by cyp2c8 [1].

References

[1] hara k,takahashi n,wakamatsu a,caltabiano s. pharmacokinetics, pharmacodynamics and safety of single, oral doses of gsk1278863, a novel hif-prolyl hydroxylase inhibitor, in healthy japanese and caucasian subjects. drug metab pharmacokinet.2015 dec;30(6):410-8.
[2] brigandi ra,johnson b,oei c,et al. a novel hypoxia-inducible factor-prolyl hydroxylase inhibitor (gsk1278863) for anemia in ckd: a 28-day, phase 2a randomized trial. am j kidney dis.2016 jun;67(6):861-71.

daprodustat,GSK1278863 Preparation Products And Raw materials

Raw materials

Preparation Products

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daprodustat,GSK1278863 Suppliers

Shanghai Famo Bio-chemical Technology Company Ltd.
Tel
021-36680027 15821745250
Email
fengqiang@famobiotech.com
Country
China
ProdList
539
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56
Chengdu Yuyang High-tech Development Co., Ltd.
Tel
0086-13852538605 13308012069
Email
13308012069@189.cn
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China
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31
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58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5050
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50
Jinan Guoding Pharmaceutical Technology Co., Ltd.
Tel
13153182316
Fax
053167801621
Email
sales@guodingpharma.com
Country
China
ProdList
488
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58
Shanghai Xinlitai Pharmaceutical Co. , Ltd.
Tel
18616665298
Email
wenjie.li@bocimed.com
Country
China
ProdList
231
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58
WuHu Linze pharmaceutical Co.,Ltd.
Tel
0553-0553-5802116 18356571950
Fax
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Email
2592492800@qq.com
Country
China
ProdList
57
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58
Shandong Loncom Pharmaceutical Co., Ltd.
Tel
0531-88072380 0531-88116830 13791093792
Email
sales@bestcomm.cn
Country
China
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TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.
Tel
022-60182192,1339732154 18722583064
Fax
86-22-60979672
Email
marketing@pharmacn.com
Country
China
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Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
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China
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2922
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55
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 17702719238
Email
sales@sun-shinechem.com
Country
China
ProdList
960
Advantage
64
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View Lastest Price from daprodustat,GSK1278863 manufacturers

Wuhan Nutra Biotechnology Co.,Ltd
Product
Daprodustat 960539-70-2
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
100kgs
Release date
2021-05-24
Hangzhou Hyper Chemicals Limited
Product
Daprodustat 960539-70-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
EP/USP
Supply Ability
1 ton
Release date
2024-09-06
Shaanxi Dideu Medichem Co. Ltd
Product
Daprodustat 960539-70-2
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000Tons
Release date
2024-08-04

960539-70-2, daprodustat,GSK1278863Related Search:


  • daprodustat,GSK1278863
  • GSK1278863
  • Daprodustat
  • 2-(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carboxamido)acetic acid
  • N-[(1,3-Dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]glycine
  • GSK1278863; GSK 1278863; GSK-1278863; DAPRODUSTAT
  • 2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid
  • GSK1278863,daprodustat
  • CS-1541
  • Daprodustat, >98%
  • GSK1278863, >98%
  • (1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine
  • GSK 1278863 NEW
  • Glycine, N-[(1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]-
  • Daprodustat Impurity 3
  • 13C12]-Daprodustat
  • 960539-70-2
  • API