ChemicalBook > CAS DataBase List > daprodustat,GSK1278863

daprodustat,GSK1278863

Product Name
daprodustat,GSK1278863
CAS No.
960539-70-2
Chemical Name
daprodustat,GSK1278863
Synonyms
CS-1541;GSK1278863;Daprodustat;GSK 1278863 NEW;GSK1278863, >98%;Daprodustat, >98%;GSK1278863,daprodustat;daprodustat,GSK1278863;Daprodustat Impurity 3;GSK1278863; GSK 1278863; GSK-1278863; DAPRODUSTAT
CBNumber
CB63038532
Molecular Formula
C19H27N3O6
Formula Weight
393.43
MOL File
960539-70-2.mol
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daprodustat,GSK1278863 Property

Melting point:
237-241oC
Density 
1.359±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), DMSO (Slightly)
pka
3.44±0.10(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19915
Product name
Daprodustat
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19915
Product name
Daprodustat
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
19915
Product name
Daprodustat
Purity
≥98%
Packaging
10mg
Price
$261
Updated
2024/03/01
Cayman Chemical
Product number
19915
Product name
Daprodustat
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
TRC
Product number
D193368
Product name
Daprodustat
Packaging
10mg
Price
$90
Updated
2021/12/16
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daprodustat,GSK1278863 Chemical Properties,Usage,Production

Uses

Daprodustat is a novel HIF (Hypoxia inducible factor)-prolyl hydroxylase inhibitor.

Biological Activity

daprodustat (gsk1278863) is a hif-prolyl hydroxylase inhibitor.hypoxia stimulates erythropoietin (epo) release through accumulation of hypoxia-inducible factor 1α (hif-1α), resulting in an increase of erythrocyte production by the bone marrow. hif-prolyl hydroxylase inhibitors have been used to selectively activate the phd-signaling pathway, leading to the stabilization of hifα subunits, which can affect the transcription of hif-responsive genes.

in vitro

in-vitro biotransformation data indicated that gsk1278863 was primarily metabolized by cyp2c8 [1].

References

[1] hara k,takahashi n,wakamatsu a,caltabiano s. pharmacokinetics, pharmacodynamics and safety of single, oral doses of gsk1278863, a novel hif-prolyl hydroxylase inhibitor, in healthy japanese and caucasian subjects. drug metab pharmacokinet.2015 dec;30(6):410-8.
[2] brigandi ra,johnson b,oei c,et al. a novel hypoxia-inducible factor-prolyl hydroxylase inhibitor (gsk1278863) for anemia in ckd: a 28-day, phase 2a randomized trial. am j kidney dis.2016 jun;67(6):861-71.

daprodustat,GSK1278863 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from daprodustat,GSK1278863 manufacturers

Wuhan Nutra Biotechnology Co.,Ltd
Product
Daprodustat 960539-70-2
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
100kgs
Release date
2021-05-24
Career Henan Chemical Co
Product
daprodustat,GSK1278863 960539-70-2
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

960539-70-2, daprodustat,GSK1278863Related Search:

N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide GSK-2126458 ABT 702 Dihydrochloride Danirixin GSK1940029 GSK 189254A GSK2110183 gsk2200150a 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

  • daprodustat,GSK1278863
  • GSK1278863
  • Daprodustat
  • 2-(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carboxamido)acetic acid
  • N-[(1,3-Dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]glycine
  • GSK1278863; GSK 1278863; GSK-1278863; DAPRODUSTAT
  • 2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid
  • GSK1278863,daprodustat
  • CS-1541
  • Daprodustat, >98%
  • GSK1278863, >98%
  • (1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine
  • GSK 1278863 NEW
  • Glycine, N-[(1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]-
  • Daprodustat Impurity 3
  • 960539-70-2
  • API