ABT 702 Dihydrochloride

Product Name: ABT 702 Dihydrochloride
CAS No.: 1188890-28-9
Chemical Name: ABT 702 Dihydrochloride
Synonyms: CS-2726;ABT702 hcl;ABT-702;ABT702;ABT 702;5-(3-Bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine dihydrochloride;ABT702 dihydrochloride,ABT702,ADK,Inhibitor,inhibit,ABT 702,ABT-702,Adenosine Kinase,ABT 702 dihydrochloride
CBNumber: CB83354238
Molecular Formula: C22H19N6OBr.2HCl
Formula Weight: 0
MOL File: Mol file

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ABT 702 Dihydrochloride Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: insoluble in H2O; ≥107.2 mg/mL in DMSO; ≥9.84 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
color: Orange

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A112435
Product name: ABT702Dihydrochloride
Packaging: 10mg
Price: $280
Updated: 2021/12/16

AK Scientific

Product number: 9463CW
Product name: AdenosineKinaseInhibitor
Packaging: 100mg
Price: $460
Updated: 2021/12/16

ChemScene

Product number: CS-0025018
Product name: ABT-702dihydrochloride
Purity: 96.36%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0025018
Product name: ABT-702dihydrochloride
Purity: 96.36%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0025018
Product name: ABT-702dihydrochloride
Purity: 96.36%
Packaging: 100mg
Price: $1100
Updated: 2021/12/16

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ABT 702 Dihydrochloride Chemical Properties,Usage,Production

Biological Activity

adenosine (ado) is an endogenous homeostatic inhibitory neuromodulator that reduces cellular excitability at sites of tissue injury and inflammation. inhibition of adenosine kinase (ak), the primary metabolic enzyme for ado, selectively increases ado concentrations at sites of tissue trauma and enhances the analgesic and antiinflammatory actions of ado. abt 702 is a novel, potent nonnucleoside ak inhibitor.

in vitro

abt 702 was active both in inhibiting ak (ic50 ) 1.7 nm) and ado phosphorylation in the intact cells (ic50 ) 50 nm). abt 702 was also highly selective for ak inhibition as compared to other sites of ado action including ada, ado receptors, and ado transport sites [1].

in vivo

abt 702 had dose-dependent antinociceptive and antiinflammatory actions in a variety of animal models of nociceptive, inflammatory, and neuropathic pain. abt 702 is the first of a novel class of potent, selective, non-nucleoside, orally active ak inhibitors that have potent antinociceptive effects in animal models [1].

IC 50

1.7 nm for adenosine kinase

References

[1] lee ch, jiang m, cowart m, gfesser g, perner r, kim kh, gu yg, williams m, jarvis mf, kowaluk ea, stewart ao, bhagwat ss. discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.. j med chem. 2001 jun 21;44(13):2133-8.

ABT 702 Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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ABT 702 Dihydrochloride Suppliers

China 41 India 1 United Kingdom 1 United States 7 Global 50

Shanghai Boyle Chemical Co., Ltd.

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Aikon International Limited

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Twochem Co.Ltd.

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Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

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InvivoChem

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ABT702 hcl

CS-2726

ABT-702;ABT702;ABT 702

5-(3-Bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine dihydrochloride

ABT702 dihydrochloride,ABT702,ADK,Inhibitor,inhibit,ABT 702,ABT-702,Adenosine Kinase,ABT 702 dihydrochloride

1188890-28-9