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ABT 702 Dihydrochloride

Product Name
ABT 702 Dihydrochloride
CAS No.
1188890-28-9
Chemical Name
ABT 702 Dihydrochloride
Synonyms
CS-2726;ABT702 hcl;ABT-702;ABT702;ABT 702;5-(3-Bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine dihydrochloride;ABT702 dihydrochloride,ABT702,ADK,Inhibitor,inhibit,ABT 702,ABT-702,Adenosine Kinase,ABT 702 dihydrochloride
CBNumber
CB83354238
Molecular Formula
C22H19N6OBr.2HCl
Formula Weight
0
MOL File
Mol file
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ABT 702 Dihydrochloride Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
insoluble in H2O; ≥107.2 mg/mL in DMSO; ≥9.84 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
color 
Orange
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A112435
Product name
ABT702Dihydrochloride
Packaging
10mg
Price
$280
Updated
2021/12/16
AK Scientific
Product number
9463CW
Product name
AdenosineKinaseInhibitor
Packaging
100mg
Price
$460
Updated
2021/12/16
ChemScene
Product number
CS-0025018
Product name
ABT-702dihydrochloride
Purity
96.36%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0025018
Product name
ABT-702dihydrochloride
Purity
96.36%
Packaging
50mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0025018
Product name
ABT-702dihydrochloride
Purity
96.36%
Packaging
100mg
Price
$1100
Updated
2021/12/16
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ABT 702 Dihydrochloride Chemical Properties,Usage,Production

Biological Activity

adenosine (ado) is an endogenous homeostatic inhibitory neuromodulator that reduces cellular excitability at sites of tissue injury and inflammation. inhibition of adenosine kinase (ak), the primary metabolic enzyme for ado, selectively increases ado concentrations at sites of tissue trauma and enhances the analgesic and antiinflammatory actions of ado. abt 702 is a novel, potent nonnucleoside ak inhibitor.

in vitro

abt 702 was active both in inhibiting ak (ic50 ) 1.7 nm) and ado phosphorylation in the intact cells (ic50 ) 50 nm). abt 702 was also highly selective for ak inhibition as compared to other sites of ado action including ada, ado receptors, and ado transport sites [1].

in vivo

abt 702 had dose-dependent antinociceptive and antiinflammatory actions in a variety of animal models of nociceptive, inflammatory, and neuropathic pain. abt 702 is the first of a novel class of potent, selective, non-nucleoside, orally active ak inhibitors that have potent antinociceptive effects in animal models [1].

IC 50

1.7 nm for adenosine kinase

References

[1] lee ch, jiang m, cowart m, gfesser g, perner r, kim kh, gu yg, williams m, jarvis mf, kowaluk ea, stewart ao, bhagwat ss. discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.. j med chem. 2001 jun 21;44(13):2133-8.

ABT 702 Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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ABT 702 Dihydrochloride Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
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sales@boylechem.com
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China
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2922
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55
Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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meilunui@163.com
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China
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58
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696,15000506266 15000506266
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+86-21-52996696
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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Shanghai Rechem science Co., Ltd.
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21-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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China
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Shanghai Chaolan Chemical Technology Center
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QQ:65489617 15618227136
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21-5161 9052
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info@SuperLan-chem.com
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China
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6527
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Aikon International Limited
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025-66028182 18112977050
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(3)02557626880
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cfzhang@aikonchem.com
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China
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15818
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Twochem Co.Ltd.
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021-58111628 15800915896
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QQ 3285589261
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sales@twochem.com
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China
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Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
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18081075745
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chemflowtech@sina.com
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China
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1886
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58
InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
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6391
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