4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
- Product Name
- 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
- CAS No.
- 349085-82-1
- Chemical Name
- 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
- Synonyms
- CS-2460;SK 137647;GSK137647;GSK137647A;GSK137647A, >98%;GSK137647A ，S0001;GSK137647A, 10 mM in DMSO;FFA4 (GPR120) agonist GS137647A;FFA4 (GPR120) agonist GSK137647A;4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide
- CBNumber
- CB22635143
- Molecular Formula
- C16H19NO3S
- Formula Weight
- 305.39
- MOL File
- 349085-82-1.mol
4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Property
- Boiling point:
- 438.1±55.0 °C(Predicted)
- Density
- 1.214±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble to 100 mM in DMSO and to 50 mM in ethanol.
- form
- powder
- pka
- 9.23±0.10(Predicted)
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
- InChI
- 1S/C16H19NO3S/c1-11-9-12(2)16(13(3)10-11)17-21(18,19)15-7-5-14(20-4)6-8-15/h5-10,17H,1-4H3
- InChIKey
- FQUAFMNPXPXOJE-UHFFFAOYSA-N
- SMILES
- CC1=C(NS(C2=CC=C(OC)C=C2)(=O)=O)C(C)=CC(C)=C1
- CAS DataBase Reference
- 349085-82-1
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- SML1152
- Product name
- GSK137647A
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $111
- Updated
- 2026/03/19
- Product number
- SML1152
- Product name
- GSK137647A
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $446
- Updated
- 2026/03/19
- Product number
- 17712
- Product name
- GSK137647A
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 17712
- Product name
- GSK137647A
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 17712
- Product name
- GSK137647A
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $239
- Updated
- 2024/03/01
4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Chemical Properties,Usage,Production
Description
GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively.1 GSK-137647 enhances glucose-stimulated insulin secretion in mouse insulinoma cells and induces intracellular calcium increase in U2OS osteosarcoma cells expressing GPR120.2
Uses
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide is involved in long-chain fatty acid stimulated GLP-1 secretion and has been implicated in glucose homeostasis, adiposity, and regulation of the anti-inflammatory response. It enhances glucose-stimulated insulin secretion in MIN6 cells. It induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614.
Synthesis
In 200 mL of dichloromethane, 2,4,6-trimethylaniline was added, cooled to below 0 in an ice-salt bath, p-methoxybenzenesulfonyl chloride was added dropwise to the dichloromethane solution, and the reaction was heated to reflux 6 . h, the reaction solution was poured into crushed ice and extracted with ethyl acetate for 3 times. times, combined organic phases, the solvent was removed under reduced pressure, the concentrated solution was taken ethyl acetate, washed with brine, partitioned, concentrated filtrate, ethyl acetate recrystallization, obtained 4-methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide solid.
in vitro
gsk137647a (50 μm) induced a concentration-dependent increase in glucose (25 mm)-stimulated insulin secretion in min6 mouse insulinoma cell line [1]. in addition, gsk137647a (100 μm) induced a modest increase in glp-1 secretion in the human intestinal cell line nci-h716. moreover, gsk137647a induced intracellular calcium accumulation in u2os cells [1].
in vivo
gsk137647a (50 μm) induced active glp-1 release by mouse circumvallate papillae (cvps) [2].
target
ffa4/gpr120
storage
Store at RT
References
[1] CÉLINE MARTIN. Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity.[J]. Journal of Lipid Research, 2012, 53 11: 2256-2265. DOI:10.1194/jlr.m025874
[2] STEVEN M. SPARKS . Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)[J]. Bioorganic & Medicinal Chemistry Letters, 2014, 24 14: Pages 3100-3103. DOI:10.1016/j.bmcl.2014.05.012
4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% manufacturers
- Product
- 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% 349085-82-1
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 95%~99%
- Supply Ability
- per week:100kg
- Release date
- 2019-09-05