ChemicalBook > CAS DataBase List > 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%

Product Name
4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
CAS No.
349085-82-1
Chemical Name
4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
Synonyms
CS-2460;GSK137647;GSK137647A;GSK137647A, >98%;FFA4 (GPR120) agonist GS137647A;FFA4 (GPR120) agonist GSK137647A;Benzenesulfonamide, 4-methoxy-N-(2,4,6-trimethylphenyl)-;GSK137647A;GSK-137647A;GSK 137647A;GSK-137647;GSK 137647;4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide,97%;4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
CBNumber
CB22635143
Molecular Formula
C16H19NO3S
Formula Weight
305.39
MOL File
349085-82-1.mol
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4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Property

Boiling point:
438.1±55.0 °C(Predicted)
Density 
1.214±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble to 100 mM in DMSO and to 50 mM in ethanol.
form 
powder
pka
9.23±0.10(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
CAS DataBase Reference
349085-82-1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1152
Product name
GSK137647A
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1152
Product name
GSK137647A
Purity
≥98% (HPLC)
Packaging
25mg
Price
$476
Updated
2024/03/01
Alfa Aesar
Product number
H57808
Product name
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide, 97%
Packaging
1g
Price
$255
Updated
2021/12/16
Alfa Aesar
Product number
H57808
Product name
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide, 97%
Packaging
250mg
Price
$80.6
Updated
2021/12/16
Cayman Chemical
Product number
17712
Product name
GSK137647A
Purity
≥98%
Packaging
5mg
Price
$62
Updated
2024/03/01
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4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Chemical Properties,Usage,Production

Description

GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively.1 GSK-137647 enhances glucose-stimulated insulin secretion in mouse insulinoma cells and induces intracellular calcium increase in U2OS osteosarcoma cells expressing GPR120.2

Uses

4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide is involved in long-chain fatty acid stimulated GLP-1 secretion and has been implicated in glucose homeostasis, adiposity, and regulation of the anti-inflammatory response. It enhances glucose-stimulated insulin secretion in MIN6 cells. It induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614.

in vitro

gsk137647a (50 μm) induced a concentration-dependent increase in glucose (25 mm)-stimulated insulin secretion in min6 mouse insulinoma cell line [1]. in addition, gsk137647a (100 μm) induced a modest increase in glp-1 secretion in the human intestinal cell line nci-h716. moreover, gsk137647a induced intracellular calcium accumulation in u2os cells [1].

in vivo

gsk137647a (50 μm) induced active glp-1 release by mouse circumvallate papillae (cvps) [2].

target

ffa4/gpr120

storage

Store at RT

References

1) Martin?et al. (2012),?Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity; J. Lipid Res.,?53?2256 2) Sparks?et al. (2014),?Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120); Bioorg. Med. Chem. Lett.,?24?3100

4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% manufacturers

Career Henan Chemical Co
Product
4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97% 349085-82-1
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

349085-82-1, 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%Related Search:

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  • 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
  • GSK137647A
  • GSK137647
  • 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide,97%
  • GSK137647A;GSK-137647A;GSK 137647A;GSK-137647;GSK 137647
  • GSK137647A, >98%
  • CS-2460
  • FFA4 (GPR120) agonist GS137647A
  • Benzenesulfonamide, 4-methoxy-N-(2,4,6-trimethylphenyl)-
  • FFA4 (GPR120) agonist GSK137647A
  • 349085-82-1
  • API