daprodustat,GSK1278863
- Product Name
- daprodustat,GSK1278863
- CAS No.
- 960539-70-2
- Chemical Name
- daprodustat,GSK1278863
- Synonyms
- CS-1541;GSK1278863;Daprodustat;GSK 1278863 NEW;GSK1278863, >98%;Daprodustat, >98%;13C12]-Daprodustat;GSK1278863,daprodustat;daprodustat,GSK1278863;Daprodustat Impurity 3
- CBNumber
- CB63038532
- Molecular Formula
- C19H27N3O6
- Formula Weight
- 393.43
- MOL File
- 960539-70-2.mol
daprodustat,GSK1278863 Property
- Melting point:
- 237-241oC
- Density
- 1.359±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- pka
- 3.44±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 19915
- Product name
- Daprodustat
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19915
- Product name
- Daprodustat
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 19915
- Product name
- Daprodustat
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $261
- Updated
- 2024/03/01
- Product number
- 19915
- Product name
- Daprodustat
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- D193368
- Product name
- Daprodustat
- Packaging
- 10mg
- Price
- $90
- Updated
- 2021/12/16
daprodustat,GSK1278863 Chemical Properties,Usage,Production
Uses
Daprodustat is a novel HIF (Hypoxia inducible factor)-prolyl hydroxylase inhibitor.
Biological Activity
daprodustat (gsk1278863) is a hif-prolyl hydroxylase inhibitor.hypoxia stimulates erythropoietin (epo) release through accumulation of hypoxia-inducible factor 1α (hif-1α), resulting in an increase of erythrocyte production by the bone marrow. hif-prolyl hydroxylase inhibitors have been used to selectively activate the phd-signaling pathway, leading to the stabilization of hifα subunits, which can affect the transcription of hif-responsive genes.
in vitro
in-vitro biotransformation data indicated that gsk1278863 was primarily metabolized by cyp2c8 [1].
References
[1] hara k,takahashi n,wakamatsu a,caltabiano s. pharmacokinetics, pharmacodynamics and safety of single, oral doses of gsk1278863, a novel hif-prolyl hydroxylase inhibitor, in healthy japanese and caucasian subjects. drug metab pharmacokinet.2015 dec;30(6):410-8.
[2] brigandi ra,johnson b,oei c,et al. a novel hypoxia-inducible factor-prolyl hydroxylase inhibitor (gsk1278863) for anemia in ckd: a 28-day, phase 2a randomized trial. am j kidney dis.2016 jun;67(6):861-71.
daprodustat,GSK1278863 Preparation Products And Raw materials
Raw materials
Preparation Products
daprodustat,GSK1278863 Suppliers
View Lastest Price from daprodustat,GSK1278863 manufacturers
- Product
- Daprodustat 960539-70-2
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100kgs
- Release date
- 2021-05-24
- Product
- Daprodustat 960539-70-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- EP/USP
- Supply Ability
- 1 ton
- Release date
- 2024-09-06
- Product
- Daprodustat 960539-70-2
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000Tons
- Release date
- 2024-08-04