ChemicalBook > CAS DataBase List > Copper tripeptide

Copper tripeptide

Product Name
Copper tripeptide
CAS No.
89030-95-5
Chemical Name
Copper tripeptide
Synonyms
Copper tripeptide;GHK Copper;DEXM74;Ghk-Cu;DEX M 74;DEX M-74;DEX-M-74;GHK.CU.HAC;GHK-Cu (1:1);Ghk-Cu/AHK-CU
CBNumber
CB52651405
Molecular Formula
C14H21CuN6O4
Formula Weight
400.91
MOL File
89030-95-5.mol
More
Less

Copper tripeptide Property

storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Soluble in DMSO
Sequence
(Cu2+ )H-Glu-His-Lys-OH
InChI
InChI=1/C14H23N6O4.Cu/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9;/h7-8,10-11,16H,1-6,15H2,(H4,17,18,19,20,21,22,23,24);/q-1;+3/p-2/t10-,11-;/s3
InChIKey
DDNUEECOCUBKBT-MIIMWFGWNA-L
SMILES
C([C@@H]1CC2=CNC=N2[Cu+2]2NCC(=O)[N-]12)(=O)N[C@H](C(=O)[O-])CCCCN |&1:1,16,r|
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
C685438
Product name
CopperPeptide(GHK-Cu)
Packaging
500mg
Price
$130
Updated
2021/12/16
ChemScene
Product number
CS-0015088
Product name
Coppertripeptide
Purity
99.40%
Packaging
500mg
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC138108
Product name
Copper peptide(GHK-Cu)
Packaging
2g
Price
$170
Updated
2021/12/16
ChemScene
Product number
CS-0015088
Product name
Coppertripeptide
Purity
99.40%
Packaging
250mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC138108
Product name
Copper peptide(GHK-Cu)
Packaging
1g
Price
$90
Updated
2021/12/16
More
Less

Copper tripeptide Chemical Properties,Usage,Production

Description

Copper tripeptide, also known as [N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper or GHK-Cu, is a naturally occurring tripeptide. It was first isolated from human plasma but can be found in saliva and urine. During wound healing, it may be freed from existing extracellular proteins via proteolysis. Studies have shown that GHK-Cu has a maximal biological effect at 10-9 mol/L and Its concentration in the body decreases with age[1].

Uses

Copper tripeptide (GHK-Cu) can be used as a skin antiaging agent. It could lead to the extracellular matrix accumulation increases in the rat wound model. Copper Peptide preparations were able to promote wound healing rates in diabetic ulcers and patients undergoing Mohs surgery. It could induce angiogenesis in rabbit models at 10?12 mol/L by acting as a chemoattractant for capillary cells. It may also improve the autocrine growth factor milieu in keloid fibroblasts[1-2]. It can also be doped into It can also be doped into binary binary PBDB-T: ITIC to tune the crystallinity and phase separation of the active layer, improving the performance of polymer solar cells[3].

Mechanism of action

At this concentration (10-9 mol/L), GHK-Cu has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. It has been demonstrated that GHK-Cu stimulates cultured normal fibroblasts to synthesize collagen and induces a dose-dependent increase in the synthesis of glycosaminoglycans. It could stimulate the regeneration of skin, nervous tissue, bones, lungs, and liver, protect the liver from oxidative damage, restore the activity of irradiated fibroblasts, reduce inflammation, and increase levels of antioxidant enzymes[1].

Side effects

Copper tripeptide (GHK-Cu) is considered to be very safe but there are always a few side effects related to any substance that is taken for health. When using creams, you might have mild skin irritation if you are one of the very few people with sensitivity. When the substance has been injected, people have reported that they experience cramping and burning at the injection site.
Other reported side effects are: Headache; Dizziness; Fatigue; Nausea; Elevated blood pressure; Lowered blood pressure; Increase in appetite; Redness and pain at the injection site; Cramping at the injection site.

References

[1] Jeffrey D, et al. Effects of Copper Tripeptide on the Growth and Expression of Growth Factors by Normal and Irradiated Fibroblasts. Archives of Facial Plastic Surgery, 2005; 7.
[2] Huang J, et al. Efficient Ternary Polymer Solar Cells with Tunable Crystallinity and Phase Separation of Active Layers via Incorporating GHK-Cu. ACS Applied Materials Interfaces, 2021; 13: 46927–46937.
[3] Pickart L, et al.Modulation of Gene Expression in Human Breast Cancer MCF7 and Prostate Cancer PC3 Cells by the Human Copper-Binding Peptide GHK-Cu, 2021; 5.

Copper tripeptide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Copper tripeptide Suppliers

China 166 India 1 United Kingdom 1 United States 8 USA 1 Global 177
Jiangsu Curtius Biotech Co.,Ltd
Tel
051389078808 18914398991
Email
3466168391@qq.com
Country
China
ProdList
8
Advantage
58
Spec-Chem Industry Inc.
Tel
13505162978
Email
sc@specchemind.com
Country
China
ProdList
93
Advantage
58
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5503
Advantage
55
Chengdu Youngshe Chemical Co., Ltd.
Tel
028-62328193 17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
2353
Advantage
58
Shenzhen Readline Biotech CO., LTD.
Tel
0755-26659310 15915457431
Fax
0755-26659310
Email
linkunsheng@szreadline.com
Country
China
ProdList
110
Advantage
58
Taiyuan Bailihengkang Biotechnology Co., Ltd
Tel
19135651983 19135651983
Email
18611134419@163.com
Country
China
ProdList
4976
Advantage
58
Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.
Tel
027-027-65385071 17771822910
Fax
027-65526669
Email
2056564811@qq.com
Country
China
ProdList
1704
Advantage
58
BJV(SHENZHEN) BIOTECH LTD
Tel
19006605307
Email
1026972457@qq.com
Country
China
ProdList
41
Advantage
58
Shandong Jitai Biotech Co., Ltd
Tel
17686152395
Email
602406775@qq.com
Country
China
ProdList
30
Advantage
58
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
More
Less

View Lastest Price from Copper tripeptide manufacturers

Wuhan Cell Pharmaceutical Co., Ltd
Product
GHK-Cu 89030-95-5
Price
US $65.00-50.00/box
Min. Order
1box
Purity
99%
Supply Ability
cosmetic
Release date
2023-11-14
Shanghai Getian Industrial Co., LTD
Product
Copper tripeptide 89030-95-5
Price
US $30.00/box
Min. Order
1box
Purity
99%
Supply Ability
20000
Release date
2024-04-12
Hebei Kangcang new material Technology Co., LTD
Product
GHK-CU 89030-95-5
Price
US $55.00/box
Min. Order
10box
Purity
98%
Supply Ability
20ton
Release date
2024-03-21

89030-95-5, Copper tripeptideRelated Search:

N-[1-Deoxy-3,4:5,6-bis-O-(1-methylethylidene)-D-glucitol-1-yl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine 2-propen-1-yl ester Prezatide copper acetate TFA-VAL-TYR-VAL-OH H-GLY-PRO-HYP-OH Palmitoyl Pentapeptide Palmitoyl Tripeptide-5 Acetyl Tetrapeptide-5 Palmitoyl Hexapeptide-12 Argireline Tripeptide-1 TYR-D-ALA-GLY-PHE-LEU (2S)-N2-(1-Oxohexadecyl)-L-lysyl-L-valyl-2,4-diaminobutanoic acid bis(trifluoroacetate) Acetyl Dipeptide-1 cetyl ester MET-GLU-HIS-PHE-ARG-TRP-GLY H-VAL-TRP-OH Rigin Biotinoyl tripeptide-1 Nonapeptide-1 Ghk Copper

  • [N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper
  • Ghk-Cu/AHK-CU
  • Copper tripeptide (GHK-Cu)
  • Prezatide copper,[N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper
  • tripeptide/GHK-Cu
  • Copper peptide, GHK-Cu, Copper tripeptide-1
  • GHK Copper
  • GHK.CU.HAC
  • Copper Tripeptide-1, copper peptide, GHK-Cu
  • tripeptide-1/GHK-Cu
  • Copper tripeptide
  • Copper Tripeptide-1 (GHK-Cu) 1:1
  • [N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper USP/EP/BP
  • GHK-Cu (1:1)
  • Copper Tripeptide-1（1:1,HOAc）
  • Glycyl-histidyl-lysine, monocopper salt
  • Copper Tripeptide-1（1:1,HCl)
  • DEX M 74
  • DEX M-74
  • DEXM74
  • DEX-M-74
  • N-Acetylmannosamine hydrate
  • Peptides Tetrapeptide -1
  • Liposomal COPPER TRIPEPTIDE-1
  • COPPER TRIPRPTIDE-1
  • Copper Peptide（1:1） Acetate
  • (2S)-6-amino-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoate （Copper Peptide-1, GHK-Cu）
  • N2-(N-glycyl-L-histidyl)-L-Lysine, copper complex
  • Copper Peptide
  • Copper peptide(GHK-Cu).xHac
  • Ghk-Cu
  • GHK-Cu (Copper Peptide)50mg 100mg
  • 89030-95-5
  • C14H22CuN6O4
  • C14H22N6O4Cu
  • Pharmaceutical
  • APIs
  • 89030-95-5