Scopoletin

ChemicalBook > CAS DataBase List > Scopoletin

Product Name: Scopoletin
CAS No.: 92-61-5
Chemical Name: Scopoletin
Synonyms: Scopoletol;6-Methoxy-7-hydroxycoumarin;7-HYDROXY-6-METHOXY-2H-CHROMEN-2-ONE;6-METHOXYCOUMARIN;6-Methylesculetin;7-HYDROXY-6-METHOXY-2H-1-BENZOPYRAN-2-ONE;Baogongteng B;GELSEMINIC ACID;CHRYSATROPIC ACID;7-HYDROXY-5-METHOXYCOUMARIN
CBNumber: CB5265273
Molecular Formula: C10H8O4
Formula Weight: 192.17
MOL File: 92-61-5.mol

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Scopoletin Property

Melting point:: 203-205 °C (lit.)
Boiling point:: 288.14°C (rough estimate)
Density: 1.2932 (rough estimate)
refractive index: 1.5430 (estimate)
storage temp.: 2-8°C
solubility: Chloroform (Sightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated)
pka: 7.91±0.20(Predicted)
form: Crystalline Powder
color: Beige
Water Solubility: Slightly soluble
Merck: 14,8408
BRN: 156296
InChIKey: RODXRVNMMDRFIK-UHFFFAOYSA-N
LogP: 1.280 (est)
CAS DataBase Reference: 92-61-5(CAS DataBase Reference)
NIST Chemistry Reference: 7-Hydroxy-6-methoxy-2h-1-benzopyran-2-one(92-61-5)
EPA Substance Registry System: Scopoletin (92-61-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 2
RTECS: GN6930000
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89516
Product name: Scopoletin
Purity: phyproof? Reference Substance
Packaging: 50MG
Price: $407
Updated: 2024/03/01

Sigma-Aldrich

Product number: 38332
Product name: Scopoletin
Purity: analytical standard
Packaging: 10mg
Price: $132
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1610090
Product name: Scopoletin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20mg
Price: $229.8
Updated: 2024/03/01

TCI Chemical

Product number: S0367
Product name: Scopoletin
Purity: >98.0%(HPLC)(T)
Packaging: 100mg
Price: $107
Updated: 2024/03/01

TCI Chemical

Product number: S0367
Product name: Scopoletin
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $649
Updated: 2024/03/01

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Scopoletin Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

Scopoletin is the aglucone of Scopolin. Used for cosmetics, topical formulations, and foods. Dyes and metabolites.

Definition

ChEBI: A hydroxycoumarin that is umbelliferone bearing a methoxy substituent at position 6.

benefits

Scopoletin is a coumarin synthesized by diverse medicinal and edible plants, which plays a vital role as a therapeutic and chemopreventive agent in the treatment of a variety of diseases. Scopoletin is indicated to have antimicrobial, anticancer, anti-inflammation, anti-angiogenesis, anti-oxidation, antidiabetic, antihypertensive, hepatoprotective, and neuroprotective properties and immunomodulatory effects in both in vitro and in vivo experimental trials. In addition, it is an inhibitor of various enzymes, including choline acetyltransferase, acetylcholinesterase, and monoamine oxidase.

Synthesis Reference(s)

The Journal of Organic Chemistry, 27, p. 3083, 1962 DOI: 10.1021/jo01056a023

General Description

Scopoletin is a coumarin compound and pharmacologically active chemical that is found in various plant species.

Biochem/physiol Actions

Scopoletin significantly increases activity of lipoprotein lipase in adipocytes by promoting transcription of the LPL gene. It also partially reverses inhibition of LPL by TNF-α.

Purification Methods

Crystallise it from water, acetic acid or *C6H6/MeOH. It is dimorphic with a second m at 193-195o. It sublimes at 120-130o/12mm. [Beilstein 18 H 99, 18 I 348, 18 II 68, 18 III/IV 1323, 18/3 V 203.]

Scopoletin Preparation Products And Raw materials

Raw materials

2,4,5-Trimethoxybenzaldehyde Ethyl (triphenylphosphoranylidene)acetate Aluminum chloride N,N-Diethylaniline

Preparation Products

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Scopoletin Suppliers

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View Lastest Price from Scopoletin manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Scopoletin 92-61-5
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-06

Shaanxi Haibo Biotechnology Co., Ltd

Product: Scopoletin 92-61-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-24

Shanghai Standard Technology Co., Ltd.

Product: Scopoletin 92-61-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-09

92-61-5, ScopoletinRelated Search:

6-Methylcoumarin 3-Methoxyacetophenone 4-Methoxybenzylchloride 4'-Methoxyacetophenone p-Anisidine 7-Hydroxycoumarin Tetrahydro-4H-pyran-4-one 4'-Hydroxyacetophenone 2,2',4,4'-Tetrahydroxybenzophenone Coumarin p-Anisaldehyde SCOPARONE HYOSCINE HYDROCHLORIDE 2-Methoxyethanol (Trifluoromethoxy)benzene 4-HYDROXY MEPHENYTOIN Scopine 3,4-Dihydroxyacetophenone

Escopoletin

Scopoletine

Scopoletol

6-METHOXYCOUMARIN

6-METHOXYUMBELLIFERONE

Scopoletin,6-Methoxyumbelliferone, 7-Hydroxy-5-methoxycoumarin, 7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one, Chrysatropic acid, Esculetin-6-methyl ether, Gelseminic acid

Scopoletin (20 mg)

7-Hydroxy-6-methoxy-2H-chromen-2-one, 6-Methoxyumbelliferone, Scopoletin

6-Methoxyumbelliferone, 7-Hydroxy-5-methoxycoumarin

GelseMinic acid, Chrysatropic acid, 6-Methylesculetin

Esculetin-6-Methyl ester

Scopoletin, 95% 50MG

Esculetin-6-methyl Ether 7-Hydroxy-6-methoxycoumarin

Baogongteng B

β-Methylaesculetin

Scopoletin 6-Methoxyumbelliferone

2H-1-

2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy- (9CI)

7-hydroxy-6-methoxy-2-chromenone

7-hydroxy-6-methoxy-1-benzopyran-2-one

7-HYDROXY-5-METHOXYCOUMARIN

7-HYDROXY-6-METHOXY-2H-1-BENZOPYRAN-2-ONE

7-HYDROXY-6-METHOXY-2H-CHROMEN-2-ONE

7-HYDROXY-6-METHOXYCOUMARIN

CHRYSATROPIC ACID

ESCULETIN-6-METHYL ETHER

GELSEMINIC ACID

B-METHYLESCULETIN

SCOPOLETIN

MURRAYETIN

AKOS 214-14

SCOPOLETIN 98.0+% T

NSC 405647

SCOPOLETIN (7-HYDROXY-6-METHOXYCOUMARIN)

6-Methoxyumbelliferone, 7-Hydroxy-5-methoxycoumarin, 7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one, Chrysatropic acid, Esculetin-6-methyl ether, Gelseminic acid

Scopoletin，Escopoletin，Chrysatropic acid，Gelseminic acid，6-Methoxyumbelliferone

Scopoletin ,98%

7-hydroxy-6-methoxy-chromen-2-one

7-hydroxy-6-methoxychromen-2-one

Scopoletin,95%

Gelseminic ac

2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy-

6-Methoxy-7-hydroxycoumarin

6-Methylesculetin

6-O-Methylesculetin

7-hydroxy-6-methoxy-2h-1-benzopyran-2-on

7-hydroxy-6-methoxy-coumari

beta-Methylesculetin

Buxuletin

Coumarin, 7-hydroxy-6-methoxy-

Scopoletin, 98%, from Morus alba L.

Scopoletin (Gelseminic acid

Scopoletin &gt

Scopolitine ( synthitic)

7-Hydroxy-6-methoxycoumarin (Scopoletin)

Scopolitine

Scopoletin extrapure, 99%

Scopolamine lactone