UNC0646
- Product Name
- UNC0646
- CAS No.
- 1320288-17-2
- Chemical Name
- UNC0646
- Synonyms
- CS-792;UNC0646;UNC0646/UNC-0646;UNC 0646;UNC0646;UNC-0646;N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-Methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-aMine;N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine;N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-7-[3-(piperidin-1-yl)propoxy]-2-[4-(propan-2-yl)-1,4-diazepan-1-yl]quinazolin-4-amine;(1-CYCLOHEXYL-PIPERIDIN-4-YL)-[2-(4-ISOPROPYL-[1,4]DIAZEPAN-1-YL)-6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)-QUINAZOLIN-4-YL]-AMINE;H3K9me2,KMT1D,chromatin,EHMT1,Histone Methyltransferase,UNC-0646,SAR,inhibit,G9a,GLP,PKMT,UNC0646,Inhibitor,cell-penetration,p53;N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
- CBNumber
- CB52667561
- Molecular Formula
- C36H59N7O2
- Formula Weight
- 621.9
- MOL File
- 1320288-17-2.mol
UNC0646 Property
- Boiling point:
- 754.6±70.0 °C(Predicted)
- Density
- 1.128±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO: soluble2mg/mL, clear (warmed)
- pka
- 9.34±0.70(Predicted)
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0633
- Product name
- UNC0646
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $156
- Updated
- 2024/03/01
- Product number
- SML0633
- Product name
- UNC0646
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $496
- Updated
- 2024/03/01
- Product number
- 11085
- Product name
- UNC0646
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 11085
- Product name
- UNC0646
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 11085
- Product name
- UNC0646
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $210
- Updated
- 2024/03/01
UNC0646 Chemical Properties,Usage,Production
Description
G9a and G9a-
Uses
UNC0646 is a novel Protein lysine methyltransferase G9a inhibitor.
Definition
ChEBI: N-(1-cyclohexyl-4-piperidinyl)-6-methoxy-7-[3-(1-piperidinyl)propoxy]-2-(4-propan-2-yl-1,4-diazepan-1-yl)-4-quinazolinamine is a member of quinazolines.
storage
+4°C
References
[1] liu f, barsyte-lovejoy d, allali-hassani a, he y, herold jm, chen x, yates cm, frye sv, brown pj, huang j, vedadi m, arrowsmith ch, jin j. optimization of cellular activity of g9a inhibitors 7-aminoalkoxy-quinazolines. j med chem. 2011;54(17):6139-50.
[2] liu f, barsyte-lovejoy d, li f, xiong y, korboukh v, huang xp, allali-hassani a, janzen wp, roth bl, frye sv, arrowsmith ch, brown pj, vedadi m, jin j. discovery of an in vivo chemical probe of the lysine methyltransferases g9a and glp. j med chem. 2013;56(21):8931-42.
UNC0646 Preparation Products And Raw materials
Raw materials
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