4-Methyl-2-(1-piperidinyl)-quinoline
- Product Name
- 4-Methyl-2-(1-piperidinyl)-quinoline
- CAS No.
- 5465-86-1
- Chemical Name
- 4-Methyl-2-(1-piperidinyl)-quinoline
- Synonyms
- ML 204;NSC 25850;ML-204;ML204;4-Methyl-2-(1-piperidinyl)-quinoline;4-methyl-2-(piperidin-1-yl)quinoline;Quinoline, 4-methyl-2-(1-piperidinyl)-;Inhibitor,TRP Channel,ML 204,channels,potential,transport,inhibit,membrane,canonical,receptor,ion,ML-204,regulation,Transient receptor potential channels,ML204,transient,biophysics,TRP
- CBNumber
- CB52695379
- Molecular Formula
- C15H18N2
- Formula Weight
- 226.32
- MOL File
- 5465-86-1.mol
4-Methyl-2-(1-piperidinyl)-quinoline Property
- Melting point:
- 72-73 °C
- Boiling point:
- 177-180 °C(Press: 4.5 Torr)
- Density
- 1.102±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL at warmed (clear solution)
- form
- powder
- pka
- 7.34±0.61(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0400
- Product name
- ML204
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $127
- Updated
- 2024/03/01
- Product number
- SML0400
- Product name
- ML204
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $202
- Updated
- 2024/03/01
- Product number
- 15626
- Product name
- ML-204
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 15626
- Product name
- ML-204
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $163
- Updated
- 2024/03/01
- Product number
- 15626
- Product name
- ML-204
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $360
- Updated
- 2024/03/01
4-Methyl-2-(1-piperidinyl)-quinoline Chemical Properties,Usage,Production
Description
ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC50s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.
Uses
4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation and muscle response due to interaction with the environment.
Biochem/physiol Actions
ML204 is a potent and selective TRPC4 channel inhibitor.
storage
Store at +4°C