4-Methyl-2-(1-piperidinyl)-quinoline

ChemicalBook > CAS DataBase List > 4-Methyl-2-(1-piperidinyl)-quinoline

4-Methyl-2-(1-piperidinyl)-quinoline

Product Name: 4-Methyl-2-(1-piperidinyl)-quinoline
CAS No.: 5465-86-1
Chemical Name: 4-Methyl-2-(1-piperidinyl)-quinoline
Synonyms: ML 204;NSC 25850;ML-204;ML204;ML 204, TRPC4 blocker;4-Methyl-2-(1-piperidinyl)-quinoline;4-methyl-2-(piperidin-1-yl)quinoline;Quinoline, 4-methyl-2-(1-piperidinyl)-;Inhibitor,TRP Channel,ML 204,channels,potential,transport,inhibit,membrane,canonical,receptor,ion,ML-204,regulation,Transient receptor potential channels,ML204,transient,biophysics,TRP
CBNumber: CB52695379
Molecular Formula: C15H18N2
Formula Weight: 226.32
MOL File: 5465-86-1.mol

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4-Methyl-2-(1-piperidinyl)-quinoline Property

Melting point:: 72-73 °C
Boiling point:: 177-180 °C(Press: 4.5 Torr)
Density: 1.102±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL at warmed (clear solution)
form: powder
pka: 7.34±0.61(Predicted)
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0400
Product name: ML204
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $127
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0400
Product name: ML204
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $202
Updated: 2024/03/01

Cayman Chemical

Product number: 15626
Product name: ML-204
Purity: ≥98%
Packaging: 5mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 15626
Product name: ML-204
Purity: ≥98%
Packaging: 10mg
Price: $163
Updated: 2024/03/01

Cayman Chemical

Product number: 15626
Product name: ML-204
Purity: ≥98%
Packaging: 25mg
Price: $360
Updated: 2024/03/01

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4-Methyl-2-(1-piperidinyl)-quinoline Chemical Properties,Usage,Production

Description

ML-204 selectively blocks transient receptor potential canonical 4 (TRPC4) channels (IC₅₀s = 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). It exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5 and does not affect TRPV1, TRPV3, TRPA1, or TRPM8 channels at concentrations up to 22 μM.

Uses

4-Methyl-2-(1-piperidinyl)-quinoline is a potent inhibitor of TRPC4 channels, responsible for various stimulation and muscle response due to interaction with the environment.

Biochem/physiol Actions

ML204 is a potent and selective TRPC4 channel inhibitor.

storage

Store at +4°C

4-Methyl-2-(1-piperidinyl)-quinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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5465-86-1, 4-Methyl-2-(1-piperidinyl)-quinolineRelated Search:

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4-Methyl-2-(1-piperidinyl)-quinoline

ML 204

NSC 25850

ML-204;ML204

4-methyl-2-(piperidin-1-yl)quinoline

Quinoline, 4-methyl-2-(1-piperidinyl)-

Inhibitor,TRP Channel,ML 204,channels,potential,transport,inhibit,membrane,canonical,receptor,ion,ML-204,regulation,Transient receptor potential channels,ML204,transient,biophysics,TRP

ML 204, TRPC4 blocker

5465-86-1

5485-86-1

Inhibitors

Aromatics, Heterocycles, Inhibitors