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UNC2881

Product Name
UNC2881
CAS No.
1493764-08-1
Chemical Name
UNC2881
Synonyms
110849;UNC2881;CS-1177;UNC2881 ，S7325;UNC2881 USP/EP/BP;UNC 2881; UNC-2881;UNC2881, 10 mM in DMSO;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-((trans-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide;N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide
CBNumber
CB52715677
Molecular Formula
C25H33N7O2
Formula Weight
463.58
MOL File
1493764-08-1.mol
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UNC2881 Property

Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥13.55 mg/mL in DMSO
form 
solid
pka
12.70±0.46(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29012
Product name
UNC2881
Packaging
5mg
Price
$106
Updated
2024/03/01
Cayman Chemical
Product number
29012
Product name
UNC2881
Packaging
50mg
Price
$775
Updated
2024/03/01
Cayman Chemical
Product number
29012
Product name
UNC2881
Packaging
10mg
Price
$187
Updated
2024/03/01
Cayman Chemical
Product number
29012
Product name
UNC2881
Packaging
25mg
Price
$414
Updated
2024/03/01
Tocris
Product number
6537
Product name
UNC2881
Purity
≥98%(HPLC)
Packaging
5
Price
$89
Updated
2021/12/16
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UNC2881 Chemical Properties,Usage,Production

Description

UNC2881 is an inhibitor of Mer (IC50 = 4.3 nM), a member of the TAM family of receptor tyrosine kinases. It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC50s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC50 = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.

Uses

UNC2881 is a specific Mer tyrosine kinase inhibitor. It inhibits collagen-stimulated platelet aggregation.

in vivo

UNC2881 (3 mg/kg; p.o.; single dose) has high systemic clearance (94.5 mL/min/kg) and 14% oral bioavailability, displays terminal half-life of 0.80 h[1].
UNC2881 (3 mg/kg; i.v.; injected with VSV on days -3, -2, -1, and 0) limits Mertk signaling, and promotes the antiviral immune response, reducing the viral replication of vesicular stomatitis virus (VSV) in infected mice[2].
Pharmacokinetics of UNC2881 in mice[1]

RouteDose (mg/kg)T1/2 (h)Tmax (h)Cmax (ng/mL)AUClast (ng·h/mL)CLobs (mL/min)Vss (L/kg)F (%)
IV30.8260952794.51.65
PO30.3090.071.714
Animal Model:C57BL/6 mice (7-10 weeks old)[2]
Dosage:3 mg/kg
Administration:Intravenous injection; infected with 2×108 PFU vesicular stomatitis virus (VSV) (i.v.) on days -3, -2, -1, and 0
Result:Reduced VSV replication in spleen, liver, kidney, lung.

target

Mer tyrosine kinase

IC 50

Axl; Mer

storage

Store at +4°C

References

[1]. zhang w, mciver al, stashko ma, et al. discovery of mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. j med chem, 2013, 56(23): 9693-9700.

UNC2881 Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC2881 Suppliers

China 69 India 2 United Kingdom 2 United States 11 Global 84
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
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United States
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Target molecule Corp.
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857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
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United States
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2559
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60
Musechem
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+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
Aladdin Scientific
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Email
tp@aladdinsci.com
Country
United States
ProdList
57505
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58
ApexBio Technology
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sales@apexbt.com
Country
United States
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6251
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Cayman Chemical Company
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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United States Biological
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chemicals@usbio.net
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United States
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6214
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Matrix Scientific
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sales@matrixscientific.com
Country
United States
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1493764-08-1, UNC2881Related Search:

UNC2541 UNC 1999 UNC0379 UNC 1025 UNC2250 GSK2656157 GSK 2334470 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Afatinib AZD-9291 UNC 669 UNC0321 UNC-1215 UNC-926 Hydochloride UNC3230 UNC0646 UNC2025 UNC 1079

  • 2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide
  • UNC2881
  • N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide
  • N-(4-(1H-imidazol-1-yl)benzyl)-2-(butylamino)-4-((1r,4r)-4-hydroxycyclohexylamino)pyrimidine-5-carboxamide UNC2881
  • N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine
  • 110849
  • UNC 2881; UNC-2881
  • CS-1177
  • 5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-
  • UNC2881 USP/EP/BP
  • N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-((trans-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide
  • UNC 2881,Mer,phosphorylation,inhibit,UNC-2881,orally active,UNC2881,Tyro3,pathologic thrombosis,Axl,Inhibitor,platelet aggregation,TAM Receptor
  • UNC2881, 10 mM in DMSO
  • UNC2881 ，S7325
  • 1493764-08-1
  • Inhibitors