ChemicalBook > CAS DataBase List > SUN11602

SUN11602

Product Name: SUN11602
CAS No.: 704869-38-5
Chemical Name: SUN11602
Synonyms: CS-2504;SUN11602;SUN11602;SUN11602;SUN11602, 10 mM in DMSO;inhibit,Fibroblast growth factor receptor,SUN11602,FGFR,Inhibitor,SUN-11602;4-[[4-[[2-(4-amino-2,3,5,6-tetramethylanilino)acetyl]-methylamino]piperidin-1-yl]methyl]benzamide;4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide;Benzamide, 4-[[4-[[2-[(4-amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]-
CBNumber: CB52731145
Molecular Formula: C26H37N5O2
Formula Weight: 451.60428
MOL File: 704869-38-5.mol

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SUN11602 Property

Boiling point:: 679.8±55.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A crystalline solid
pka: 16.19±0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 4826
Product name: SUN11602
Purity: ≥98%(HPLC)
Packaging: 10
Price: $219
Updated: 2021/12/16

TRC

Product number: S688063
Product name: SUN11602
Packaging: 10mg
Price: $200
Updated: 2021/12/16

Usbiological

Product number: 256781
Product name: SUN 11602
Packaging: 10mg
Price: $466
Updated: 2021/12/16

ChemScene

Product number: CS-6383
Product name: SUN11602
Purity: 99.10%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-6383
Product name: SUN11602
Purity: 99.10%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

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SUN11602 Chemical Properties,Usage,Production

Uses

SUN 11602 is a novel aniline compound, which mimics the neuroprotective mechanisms of basic fibroblast growth factor.

Biological Activity

SUN11602 is an orally active basic fibroblast growth factor (bFGF, FGF2) mimetic th at protects against glutamate toxicity in primary r at cerebrocortical neuron (0.1-1 μM SUN11602; 150 μM glutamate) and murine hippocampal neuron cultures (0.3-3 μM SUN11602; 100 μM glutamate). When administered in vivo, SUN11602 exhibits therapeutic efficacy in a r at hippocampal-lesion model (1-10 mg/kg p.o. 24h post Aβ1-40 injection) and a murine MPTP-induced nigrostriatal degeneration model (2.5-5 mg/kg/day p.o.).

in vivo

In WT mice, SUN11602 increases the levels of newly synthesized Calb in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca²⁺. This Ca²⁺-capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate^[1]. Oral administration of SUN11602 at the midpoint of Aβ1-40 and ibotenate injections attenuate short-term memory impairment in the Y-maze test, as well as spatial learning deficits in the water maze task. In addition, the SUN11602 treatment inhibits the increase of peripheral-type benzodiazepine-binding sites (PTBBS),which are a marker for gliosis^[3].

SUN11602 Preparation Products And Raw materials

Raw materials

Preparation Products

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704869-38-5, SUN11602Related Search:

SU 6656 SU 9516 SUFUGOLIX SU 5214 3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE SU 4942 SU 11274 SU 5205 (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide SU 4312 Suvorexant Sunitinib Malate

SUN11602

4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide

CS-2504

SUN11602;SUN11602

inhibit,Fibroblast growth factor receptor,SUN11602,FGFR,Inhibitor,SUN-11602

Benzamide, 4-[[4-[[2-[(4-amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]-

SUN11602, 10 mM in DMSO

4-[[4-[[2-(4-amino-2,3,5,6-tetramethylanilino)acetyl]-methylamino]piperidin-1-yl]methyl]benzamide

704869-38-5