Csn-B

Product Name: Csn-B
CAS No.: 321661-62-5
Chemical Name: Csn-B
Synonyms: Cytosporone B;Csn-B;Dothiorelone G;ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate;Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate;(3,5-Dihydroxy-2-octanoyl-phenyl)-acetic acid ethyl ester;3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester;3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester;Benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester;N-{2-[(3-CYANO-5,7-DIMETHYL-2-QUINOLINYL)AMINO]ETHYL}-3-METHOXYBENZAMIDE
CBNumber: CB52750977
Molecular Formula: C18H26O5
Formula Weight: 322.4
MOL File: 321661-62-5.mol

More

Less

Csn-B Property

Boiling point:: 471.6±24.0 °C(Predicted)
Density: 1.126±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >20mg/mL
pka: 7.54±0.40(Predicted)
form: A crystalline solid
color: white to off-white
InChI: InChI=1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3
InChIKey: UVVWQQKSNZLUQA-UHFFFAOYSA-N
SMILES: C1(CC(OCC)=O)=CC(O)=CC(O)=C1C(=O)CCCCCCC

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C2997
Product name: Cytosporone B
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $167
Updated: 2024/03/01

Sigma-Aldrich

Product number: C2997
Product name: Cytosporone B
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $657
Updated: 2024/03/01

Cayman Chemical

Product number: 17501
Product name: Cytosporone B
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17501
Product name: Cytosporone B
Purity: ≥95%
Packaging: 5mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 17501
Product name: Cytosporone B
Purity: ≥95%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

More

Less

Csn-B Chemical Properties,Usage,Production

Uses

Cytosporone B is a naturally occuring agonist for the nuclear receptor Nur77., induces the expression of Nur77-dependent genes including the gene for Nur77 itself. Induces apoptosis in cancer cells.

Uses

Cytosporone B has been used:

as a positive control and NR4A1 agonist in NR4A1 reporter gene assay
for Nr4a1 activation
to treat OVX mice and study its effect on migration of osteoclast precursor

Definition

ChEBI: 2-[3,5-dihydroxy-2-(1-oxooctyl)phenyl]acetic acid ethyl ester is an aromatic ketone.

Biochem/physiol Actions

Cytosporone B (Csn-B) is the first naturally occurring agonist for nuclear orphan receptor Nur77. It binds with high affinity (IC50=0.278 nM) to the ligand-binding domain of Nur77 and stimulates Nur77-dependent activities. Nur77 is a nuclear receptor/transcription factor. A physiological ligand for Nur77 is as yet unknown, but there is increasing interest in Nur77 because of its known activities. Translocation of Nur77 from the nucleus to mitochondria initiates cell apoptosis, making it a potential target for cancer treatment. Nur77 is also involved in glucose homeostasis; it induces genes involved in gluconeogenesis. Csn-B physically binds to Nur77 and activates its transactivational activity and translocation to mitochondria to induce apoptosis. It inhibits cancer cell proliferation and tumor growth.

storage

Store at -20°C

Csn-B Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Csn-B Suppliers

China 88 India 1 United Kingdom 1 United States 9 USA 1 Global 100

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4573
Advantage: 55

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
Fax: -
Email: info@angtibio.com
Country: China
ProdList: 5037
Advantage: 55

ATK CHEMICAL COMPANY LIMITED

Tel: 021-51619050 13301662590
Fax: +86-21-51619052
Email: mandy@atkchemical.com
Country: China
ProdList: 10199
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27313
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

321661-62-5, Csn-BRelated Search:

beta-Eudesmol Hydroxyecdysone 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one hydroxygenkwanin MOSLOFLAVONE alpha-Cyperone (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one beta-Sitosterol alpha-Terpineol Artemether

3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester

3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester

Csn-B

Cytosporone B

ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate

Benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester

N-{2-[(3-CYANO-5,7-DIMETHYL-2-QUINOLINYL)AMINO]ETHYL}-3-METHOXYBE<WBR />NZAMIDE

Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate

Dothiorelone G

(3,5-Dihydroxy-2-octanoyl-phenyl)-acetic acid ethyl ester

321661-62-5