Rosiptor

ChemicalBook > CAS DataBase List > Rosiptor

Product Name: Rosiptor
CAS No.: 782487-28-9
Chemical Name: Rosiptor
Synonyms: AQX10;Rosiptor;semaglutide USP;semaglutide API;Rosiptor(AQX-1125);AQX 1125 (AQX-1125;semaglutide USP/EP/BP;Semaglutide-fermented;AQX-1125;AQX1125;ROSIPTOR;AQX1125,Rosiptor,Phosphatase,AQX 1125,Inhibitor,inhibit
CBNumber: CB53044080
Molecular Formula: C20H35NO2
Formula Weight: 321.5
MOL File: 782487-28-9.mol

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Rosiptor Property

Boiling point:: 451.6±45.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 150 mg/mL (466.56 mM)
pka: 15.05±0.10(Predicted)
InChI: InChI=1S/C20H35NO2/c1-13-4-5-17-16(11-21)18(7-9-19(13,17)2)20(3)8-6-15(23)10-14(20)12-22/h14-18,22-23H,1,4-12,21H2,2-3H3/t14-,15+,16+,17+,18+,19-,20+/m1/s1
InChIKey: MDEJTPWQNNMAQF-BVMLLJBZSA-N
SMILES: [C@H]1(CO)C[C@@H](O)CC[C@@]1([C@H]1CC[C@@]2(C)[C@]([H])([C@@H]1CN)CCC2=C)C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0030509
Product name: Rosiptor
Purity: ≥98.0%
Packaging: 5mg
Price: $700
Updated: 2021/12/16

ChemScene

Product number: CS-0030509
Product name: Rosiptor
Purity: ≥98.0%
Packaging: 10mg
Price: $1100
Updated: 2021/12/16

ChemScene

Product number: CS-0030509
Product name: Rosiptor
Purity: ≥98.0%
Packaging: 50mg
Price: $3500
Updated: 2021/12/16

ChemScene

Product number: CS-0030509
Product name: Rosiptor
Purity: ≥98.0%
Packaging: 100mg
Price: $5500
Updated: 2021/12/16

DC Chemicals

Product number: DC23139
Product name: AQX1125
Purity: >98%
Packaging: 1g
Price: $2800
Updated: 2021/12/16

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Rosiptor Chemical Properties,Usage,Production

Description

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. It inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.

Uses

Rosiptor has been used in trials studying the treatment of COPD, Atopic Dermatitis, Interstitial Cystitis, and Bladder Pain Syndrome.

Biological Activity

Rosiptor is a small-molecule SHIP1 activator.The activating effect of Rosiptor on SHIP1 is 28% at 100 μM in the native enzyme but no effect of Rosiptor is observed when the SHIP1δC2 enzyme is used. Rosiptor induces a concentration-dependent decrease in Akt phosphorylation in MOLT-4 cells, while it fails to affect Akt phosphorylation in Jurkat cells. At 0.1 μM Rosiptor the inhibition amounts to an average of 34%, while at 10 μM the inhibition amounts to an average of 82% in two independent experiments. Rosiptor also induces a concentration-dependent decrease in the production of multiple pro-inflammatory mediators in this system, without affecting cell viability. Rosiptor dose dependently inhibits chemotaxis of most cell types at low micromolar concentrations independent of the chemotactic stimulus.

Rosiptor Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Rosiptor manufacturers

Wuhan Cell Pharmaceutical Co., Ltd

Product: semaglutide USP；EP；BP 782487-28-9
Price: US $25.00-20.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2023-05-12

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Semaglutide 782487-28-9
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2023-01-12

qingdao future trading Co., Ltd

Product: semaglutide 782487-28-9
Price: US $1600.00/gram
Min. Order: 1gram
Purity: 99.99%
Supply Ability: 10kg
Release date: 2023-06-26

782487-28-9, RosiptorRelated Search:

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AQX10

Rosiptor

AQX-1125;AQX1125;ROSIPTOR

Rosiptor(AQX-1125)

AQX 1125 (AQX-1125

semaglutide API

Cyclohexanemethanol, 2-[(3aS,4R,5S,7aS)-4-(aminomethyl)octahydro-7a-methyl-1-methylene-1H-inden-5-yl]-5-hydroxy-2-methyl-, (1S,2R,5S)-

Semaglutide-fermented

semaglutide USP/EP/BP

AQX1125,Rosiptor,Phosphatase,AQX 1125,Inhibitor,inhibit

semaglutide USP

782487-28-9

APIs

782487-28-9