ChemicalBook > CAS DataBase List > Rosiptor

Rosiptor

Product Name: Rosiptor
CAS No.: 782487-28-9
Chemical Name: Rosiptor
Synonyms: AQX10;Rosiptor;semaglutide USP;semaglutide API;Rosiptor(AQX-1125);AQX 1125 (AQX-1125;semaglutide USP/EP/BP;Semaglutide-fermented;Rosiptor, 10 mM in DMSO;AQX-1125;AQX1125;ROSIPTOR
CBNumber: CB53044080
Molecular Formula: C20H35NO2
Formula Weight: 321.5
MOL File: 782487-28-9.mol

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Rosiptor Property

Boiling point:: 451.6±45.0 °C(Predicted)
Density: 1.07±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 150 mg/mL (466.56 mM)
pka: 15.05±0.10(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C20H35NO2/c1-13-4-5-17-16(11-21)18(7-9-19(13,17)2)20(3)8-6-15(23)10-14(20)12-22/h14-18,22-23H,1,4-12,21H2,2-3H3/t14-,15+,16+,17+,18+,19-,20+/m1/s1
InChIKey: MDEJTPWQNNMAQF-BVMLLJBZSA-N
SMILES: [C@H]1(CO)C[C@@H](O)CC[C@@]1([C@H]1CC[C@@]2(C)[C@]([H])([C@@H]1CN)CCC2=C)C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0030509
Product name: Rosiptor
Purity: ≥98.0%
Packaging: 5mg
Price: $700
Updated: 2021/12/16

ChemScene

Product number: CS-0030509
Product name: Rosiptor
Purity: ≥98.0%
Packaging: 10mg
Price: $1100
Updated: 2021/12/16

ChemScene

Product number: CS-0030509
Product name: Rosiptor
Purity: ≥98.0%
Packaging: 50mg
Price: $3500
Updated: 2021/12/16

ChemScene

Product number: CS-0030509
Product name: Rosiptor
Purity: ≥98.0%
Packaging: 100mg
Price: $5500
Updated: 2021/12/16

DC Chemicals

Product number: DC23139
Product name: AQX1125
Purity: >98%
Packaging: 1g
Price: $2800
Updated: 2021/12/16

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Rosiptor Chemical Properties,Usage,Production

Description

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. It inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.

Uses

Rosiptor has been used in trials studying the treatment of COPD, Atopic Dermatitis, Interstitial Cystitis, and Bladder Pain Syndrome.

Biological Activity

Rosiptor is a small-molecule SHIP1 activator.The activating effect of Rosiptor on SHIP1 is 28% at 100 μM in the native enzyme but no effect of Rosiptor is observed when the SHIP1δC2 enzyme is used. Rosiptor induces a concentration-dependent decrease in Akt phosphorylation in MOLT-4 cells, while it fails to affect Akt phosphorylation in Jurkat cells. At 0.1 μM Rosiptor the inhibition amounts to an average of 34%, while at 10 μM the inhibition amounts to an average of 82% in two independent experiments. Rosiptor also induces a concentration-dependent decrease in the production of multiple pro-inflammatory mediators in this system, without affecting cell viability. Rosiptor dose dependently inhibits chemotaxis of most cell types at low micromolar concentrations independent of the chemotactic stimulus.

in vivo

Rosiptor (3-30 mg/kg; p.o.; daily for 3 days) significantly reduces the total number of BAL leukocytes in NSC-125066-challenged mice and reduces MPO activity^[2].
Rosiptor (10 mg/kg; p.o.) has the C_max value of 0.830 μM and the t_1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability^[1].

Animal Model:	6-8 weeks old male CD-1 mice^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	p.o.; daily for 3 days
Result:	Significantly reduced the total number of BAL leukocytes in NSC-125066-challenged mice, up to a maximum of 60% at 7 days and 63% at 21 days at 30 mg/kg; Reduced MPO activity by 54% at Day 7 and by 74% at Day 21 at 30 mg/kg.

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	10 mg/kg (Pharmacokinetic Study)
Administration:	Oral administration
Result:	The C_max value is 0.830 μM and the t_1/2 value is 5.2 hours.

Rosiptor Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Rosiptor manufacturers

RongNa Biotechnology Co.,Ltd

Product: Rosiptor 782487-28-9
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2025-08-19

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Rosiptor 782487-28-9
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-25

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Semaglutide 782487-28-9
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2023-01-12

782487-28-9, RosiptorRelated Search:

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AQX10

Rosiptor

AQX-1125;AQX1125;ROSIPTOR

Rosiptor(AQX-1125)

AQX 1125 (AQX-1125

semaglutide API

Cyclohexanemethanol, 2-[(3aS,4R,5S,7aS)-4-(aminomethyl)octahydro-7a-methyl-1-methylene-1H-inden-5-yl]-5-hydroxy-2-methyl-, (1S,2R,5S)-

Semaglutide-fermented

semaglutide USP/EP/BP

AQX1125,Rosiptor,Phosphatase,AQX 1125,Inhibitor,inhibit

semaglutide USP

Rosiptor, 10 mM in DMSO

782487-28-9

APIs

782487-28-9