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Rosiptor

Product Name
Rosiptor
CAS No.
782487-28-9
Chemical Name
Rosiptor
Synonyms
AQX10;Rosiptor;semaglutide USP;semaglutide API;Rosiptor(AQX-1125);AQX 1125 (AQX-1125;semaglutide USP/EP/BP;Semaglutide-fermented;Rosiptor, 10 mM in DMSO;AQX-1125;AQX1125;ROSIPTOR
CBNumber
CB53044080
Molecular Formula
C20H35NO2
Formula Weight
321.5
MOL File
782487-28-9.mol
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Rosiptor Property

Boiling point:
451.6±45.0 °C(Predicted)
Density 
1.07±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 150 mg/mL (466.56 mM)
pka
15.05±0.10(Predicted)
form 
Solid
color 
White to off-white
InChI
InChI=1S/C20H35NO2/c1-13-4-5-17-16(11-21)18(7-9-19(13,17)2)20(3)8-6-15(23)10-14(20)12-22/h14-18,22-23H,1,4-12,21H2,2-3H3/t14-,15+,16+,17+,18+,19-,20+/m1/s1
InChIKey
MDEJTPWQNNMAQF-BVMLLJBZSA-N
SMILES
[C@H]1(CO)C[C@@H](O)CC[C@@]1([C@H]1CC[C@@]2(C)[C@]([H])([C@@H]1CN)CCC2=C)C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0030509
Product name
Rosiptor
Purity
≥98.0%
Packaging
5mg
Price
$700
Updated
2021/12/16
ChemScene
Product number
CS-0030509
Product name
Rosiptor
Purity
≥98.0%
Packaging
10mg
Price
$1100
Updated
2021/12/16
ChemScene
Product number
CS-0030509
Product name
Rosiptor
Purity
≥98.0%
Packaging
50mg
Price
$3500
Updated
2021/12/16
ChemScene
Product number
CS-0030509
Product name
Rosiptor
Purity
≥98.0%
Packaging
100mg
Price
$5500
Updated
2021/12/16
DC Chemicals
Product number
DC23139
Product name
AQX1125
Purity
>98%
Packaging
1g
Price
$2800
Updated
2021/12/16
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Rosiptor Chemical Properties,Usage,Production

Description

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. It inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.

Uses

Rosiptor has been used in trials studying the treatment of COPD, Atopic Dermatitis, Interstitial Cystitis, and Bladder Pain Syndrome.

Biological Activity

Rosiptor is a small-molecule SHIP1 activator.The activating effect of Rosiptor on SHIP1 is 28% at 100 μM in the native enzyme but no effect of Rosiptor is observed when the SHIP1δC2 enzyme is used. Rosiptor induces a concentration-dependent decrease in Akt phosphorylation in MOLT-4 cells, while it fails to affect Akt phosphorylation in Jurkat cells. At 0.1 μM Rosiptor the inhibition amounts to an average of 34%, while at 10 μM the inhibition amounts to an average of 82% in two independent experiments. Rosiptor also induces a concentration-dependent decrease in the production of multiple pro-inflammatory mediators in this system, without affecting cell viability. Rosiptor dose dependently inhibits chemotaxis of most cell types at low micromolar concentrations independent of the chemotactic stimulus.

in vivo

Rosiptor (3-30 mg/kg; p.o.; daily for 3 days) significantly reduces the total number of BAL leukocytes in NSC-125066-challenged mice and reduces MPO activity[2].
Rosiptor (10 mg/kg; p.o.) has the Cmax value of 0.830 μM and the t1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability[1].

Animal Model:6-8 weeks old male CD-1 mice[1]
Dosage:3, 10, 30 mg/kg
Administration:p.o.; daily for 3 days
Result:Significantly reduced the total number of BAL leukocytes in NSC-125066-challenged mice, up to a maximum of 60% at 7 days and 63% at 21 days at 30 mg/kg; Reduced MPO activity by 54% at Day 7 and by 74% at Day 21 at 30 mg/kg.
Animal Model:Male Sprague-Dawley rats[1]
Dosage:10 mg/kg (Pharmacokinetic Study)
Administration:Oral administration
Result:The Cmax value is 0.830 μM and the t1/2 value is 5.2 hours.

Rosiptor Preparation Products And Raw materials

Raw materials

Preparation Products

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Rosiptor Suppliers

China 94 India 2 United States 1 Global 97
Taj Mahal Vision Chemicals Private Limited
Tel
--
Fax
--
Country
India
ProdList
206
Advantage
58
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View Lastest Price from Rosiptor manufacturers

RongNa Biotechnology Co.,Ltd
Product
Rosiptor 782487-28-9
Price
US $10.00/ASSAYS
Min. Order
1ASSAYS
Purity
99%
Supply Ability
1 ton
Release date
2025-08-19
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Rosiptor 782487-28-9
Price
US $2.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-25
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Semaglutide 782487-28-9
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
1000g
Release date
2023-01-12

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  • AQX10
  • Rosiptor
  • AQX-1125;AQX1125;ROSIPTOR
  • Rosiptor(AQX-1125)
  • AQX 1125 (AQX-1125
  • semaglutide API
  • Cyclohexanemethanol, 2-[(3aS,4R,5S,7aS)-4-(aminomethyl)octahydro-7a-methyl-1-methylene-1H-inden-5-yl]-5-hydroxy-2-methyl-, (1S,2R,5S)-
  • Semaglutide-fermented
  • semaglutide USP/EP/BP
  • AQX1125,Rosiptor,Phosphatase,AQX 1125,Inhibitor,inhibit
  • semaglutide USP
  • Rosiptor, 10 mM in DMSO
  • 782487-28-9
  • APIs
  • 782487-28-9