Ethyl sarcosinate hydrochloride
- Product Name
- Ethyl sarcosinate hydrochloride
- CAS No.
- 52605-49-9
- Chemical Name
- Ethyl sarcosinate hydrochloride
- Synonyms
- SARCOSINE ETHYL ESTER HYDROCHLORIDE;H-SAR-OET·HCL;Ethyl sarcosinate HCL;ethyl methylglycinate hydrochloride;ethyl N-methylaminoacetate hydrochloride;ethyl 2-(methylamino)acetate hydrochloride;SAR-OET HCL;H-SAR-OE HCL;L-Sar-OEt·HCl;H-SAR-OET HCL
- CBNumber
- CB5305289
- Molecular Formula
- C5H12ClNO2
- Formula Weight
- 153.61
- MOL File
- 52605-49-9.mol
Ethyl sarcosinate hydrochloride Property
- Melting point:
- ~125 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- H2O: 0.1 g/mL, clear
- form
- Crystalline Powder
- color
- White to off-white
- Water Solubility
- Soluble in water 0.1 g/mL.
- Sensitive
- Hygroscopic
- BRN
- 3911182
- InChI
- InChI=1S/C5H11NO2.ClH/c1-3-8-5(7)4-6-2;/h6H,3-4H2,1-2H3;1H
- InChIKey
- NIDZUMSLERGAON-UHFFFAOYSA-N
- SMILES
- C(=O)(OCC)CNC.Cl
- CAS DataBase Reference
- 52605-49-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 255084
- Product name
- Sarcosine ethyl ester hydrochloride
- Purity
- 99%
- Packaging
- 10g
- Price
- $79.7
- Updated
- 2025/07/31
- Product number
- 255084
- Product name
- Sarcosine ethyl ester hydrochloride
- Purity
- 99%
- Packaging
- 50g
- Price
- $267
- Updated
- 2023/06/20
- Product number
- S0841
- Product name
- Sarcosine Ethyl Ester Hydrochloride
- Purity
- >98.0%(N)(T)
- Packaging
- 5g
- Price
- $34
- Updated
- 2025/07/31
- Product number
- S0841
- Product name
- Sarcosine Ethyl Ester Hydrochloride
- Purity
- >98.0%(N)(T)
- Packaging
- 25g
- Price
- $107
- Updated
- 2025/07/31
- Product number
- S140510
- Product name
- Sarcosine ethyl ester hydrochloride
- Packaging
- 50g
- Price
- $175
- Updated
- 2021/12/16
Ethyl sarcosinate hydrochloride Chemical Properties,Usage,Production
Chemical Properties
white to off-white crystalline solid
Uses
Sarcosine ethyl ester hydrochloride is a metabolite of Sarcosine (S140500), which as been found in starfish and sea urchins. It is used as intermediate in the synthesis of antienzyme agents for toothpaste. Found to be a marker for prostate cancer bioagression.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
107-97-1
52605-49-9
Thiophenecarbonyl chloride (65 mL, 900 mmol) was added dropwise to a solution of sarcosine (20.0 g, 224 mmol) in ethanol (250 mL) cooled in an ice-water bath under stirring conditions, and the reaction temperature was maintained at about -10°C. After the dropwise addition was completed, the reaction mixture was gently heated at 55°C overnight until the solution became clear. Upon completion of the reaction, the solvent and residual thionyl chloride were removed by distillation under reduced pressure. The resulting solid residue was washed with ether (3 x 50 mL) and subsequently dried well under vacuum to afford ethyl sarcosinate hydrochloride (33.5 g, 218 mmol) in white powder form in 97% yield. The product could be used in subsequent steps without further purification. The product was characterized as follows: melting point 126°C (literature value 125-127°C); IR (ATR) ν cm?1 2970-2440, 1742, 1229; 1H NMR (CDCl?, 400 MHz) δ 9.64 (br.s, 2H, NH?), 4.24 (q, 2H, 3J = 7.1 Hz, CH?CH?), 3.84 (t, 2H, 3J = 7.1 Hz, CH?CH?), 4.24 (q, 2H, 3J = 7.1 Hz, CH? 3.84 (t, 2H, 3J = 5.7 Hz, NH?CH?), 2.80 (t, 3H, 3J = 5.2 Hz, NH?CH?), 1.26 (t, 3H, 3J = 7.1 Hz, CH?CH?); 13C NMR (CDCl?, 101 MHz) δ 166.18 (CO?), 62.62 (CH?CH?), 48.94 (NH?CH?), 33.34 (NH?CH?), 14.03 (CH?CH?).
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 51 - 67
[2] Patent: US4432971, 1984, A
[3] Patent: US4432972, 1984, A
Ethyl sarcosinate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl sarcosinate hydrochloride Suppliers
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View Lastest Price from Ethyl sarcosinate hydrochloride manufacturers
- Product
- Ethyl sarcosinate hydrochloride 52605-49-9
- Price
- US $1.00-4.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2025-09-04
- Product
- H-Sar-OEt.HCl 52605-49-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-04-08
- Product
- Ethyl sarcosinate hydrochloride 52605-49-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-10