ChemicalBook > CAS DataBase List > NSC5844

NSC5844

Product Name: NSC5844
CAS No.: 140926-75-6
Chemical Name: NSC5844
Synonyms: RE640;RE 640;RE-640;NSC5844;NSC5844 (RE640);NSC-5844 (NSC 5844;NSC 5844; NSC-5844; RE 640; RE-640; RE640;N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine;1,2-Ethanediamine, N1,N2-bis(7-chloro-4-quinolinyl)-;NSC 5844,RE640,NSC5844,inhibit,Inhibitor,RE 640,Parasite,NSC-5844
CBNumber: CB53121123
Molecular Formula: C20H16Cl2N4
Formula Weight: 383.27
MOL File: 140926-75-6.mol

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NSC5844 Property

Boiling point:: 632.6±55.0 °C(Predicted)
Density: 1.431±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 0.33 mg/ml; DMSO: 0.25 mg/ml; Ethanol: slightly soluble
form: A crystalline solid
pka: 6.61±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23443
Product name: NSC 5844
Purity: ≥95%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 23443
Product name: NSC 5844
Purity: ≥95%
Packaging: 10mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 23443
Product name: NSC 5844
Purity: ≥95%
Packaging: 25mg
Price: $336
Updated: 2024/03/01

Cayman Chemical

Product number: 23443
Product name: NSC 5844
Purity: ≥95%
Packaging: 50mg
Price: $593
Updated: 2024/03/01

TRC

Product number: B425860
Product name: N1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine
Packaging: 5mg
Price: $65
Updated: 2021/12/16

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NSC5844 Chemical Properties,Usage,Production

Description

NSC 5844 is a bis-quinoline with diverse biological activities. It inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine in vitro (IC₅₀s = 17 and 27 nM, respectively) but lacks activity against P. berghei in vivo. NSC 5844 inhibits the growth of MDA-MB-468 and MCF-7 breast cancer cells with GI₅₀ values of 7.35 and 14.80 μM, respectively. It also inhibits 24% of botulinum neurotoxin serotype A light chain (BoNT/A LC) metalloprotease activity at a concentration of 20 μM.

Uses

N1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine and other bisquinoline derivatives have potentials against chloroquine-resistant malaria. A useful intermediate for the preparation of other antimalarial bisaminoquinlines.

IC 50

Plasmodium

References

[1] JONATHAN L. VENNERSTROM. Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria[J]. Journal of Medicinal Chemistry, 1992, 35 11: 2129-2134. DOI: 10.1021/jm00089a025
[2] HAIWEN ZHANG . Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives[J]. Biomedicine & Pharmacotherapy, 2008, 62 2: Pages 65-69. DOI: 10.1016/j.biopha.2007.04.007
[3] JAMES C BURNETT . Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity[J]. Biochemical and biophysical research communications, 2003, 310 1: Pages 84-93. DOI: 10.1016/j.bbrc.2003.08.112

NSC5844 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC5844 (RE640)

NSC 5844; NSC-5844; RE 640; RE-640; RE640

RE 640

RE640

RE-640

NSC5844

N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine

1,2-Ethanediamine, N1,N2-bis(7-chloro-4-quinolinyl)-

NSC 5844,RE640,NSC5844,inhibit,Inhibitor,RE 640,Parasite,NSC-5844

NSC-5844 (NSC 5844

140926-75-6