ChemicalBook > CAS DataBase List > NSC5844
NSC5844
- Product Name
- NSC5844
- CAS No.
- 140926-75-6
- Chemical Name
- NSC5844
- Synonyms
- RE640;RE 640;RE-640;NSC5844;NSC5844 (RE640);NSC 5844; NSC-5844; RE 640; RE-640; RE640;N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine;1,2-Ethanediamine, N1,N2-bis(7-chloro-4-quinolinyl)-;NSC 5844,RE640,NSC5844,inhibit,Inhibitor,RE 640,Parasite,NSC-5844
- CBNumber
- CB53121123
- Molecular Formula
- C20H16Cl2N4
- Formula Weight
- 383.27
- MOL File
- 140926-75-6.mol
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NSC5844 Property
- Boiling point:
- 632.6±55.0 °C(Predicted)
- Density
- 1.431±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 0.33 mg/ml; DMSO: 0.25 mg/ml; Ethanol: slightly soluble
- form
- A crystalline solid
- pka
- 6.61±0.50(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 23443
- Product name
- NSC 5844
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 23443
- Product name
- NSC 5844
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $152
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 23443
- Product name
- NSC 5844
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $336
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 23443
- Product name
- NSC 5844
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $593
- Updated
- 2024/03/01
TRC
- Product number
- B425860
- Product name
- N1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine
- Packaging
- 10mg
- Price
- $125
- Updated
- 2021/12/16
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NSC5844 Chemical Properties,Usage,Production
Description
NSC 5844 is a bis-quinoline with diverse biological activities. It inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine in vitro (IC50s = 17 and 27 nM, respectively) but lacks activity against P. berghei in vivo. NSC 5844 inhibits the growth of MDA-MB-468 and MCF-7 breast cancer cells with GI50 values of 7.35 and 14.80 μM, respectively. It also inhibits 24% of botulinum neurotoxin serotype A light chain (BoNT/A LC) metalloprotease activity at a concentration of 20 μM.
Uses
N1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine and other bisquinoline derivatives have potentials against chloroquine-resistant malaria. A useful intermediate for the preparation of other antimalarial bisaminoquinlines.
NSC5844 Preparation Products And Raw materials
Raw materials
Preparation Products
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NSC5844 Suppliers
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2993
- Advantage
- 58
- Tel
- 18221735425
- sales@xinpingchem.com
- Country
- China
- ProdList
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- 58
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- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 7310
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- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29764
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
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- 12306
- Advantage
- 58
- Tel
- 02150565560; 17321237488
- kevin@resuperpharmtech.com
- Country
- China
- ProdList
- 357
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- Tel
- 0519-83246372 13585352506
- Fax
- 0519-83246372
- Country
- China
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- Tel
- 025-66162170
- Fax
- 025-66162170
- Country
- China
- ProdList
- 7181
- Advantage
- 55
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
- ProdList
- 4660
- Advantage
- 60
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