ChemicalBook > CAS DataBase List > 2-Chloro-4-fluorobenzothiazole

2-Chloro-4-fluorobenzothiazole

Product Name
2-Chloro-4-fluorobenzothiazole
CAS No.
182344-56-5
Chemical Name
2-Chloro-4-fluorobenzothiazole
Synonyms
IFLAB-BB F1910-0007;2-CHLORO-4-FLUOROBENZOTHIAZOLE;Benzothiazole, 2-chloro-4-fluoro-;2-Chloro-4-fluorobenzo[d]thiazole;2-CHLORO-4-FLUORO-1,3-BENZOTHIAZOLE;Benzothiazole, 2-chloro-4-fluoro- (9CI)
CBNumber
CB5313718
Molecular Formula
C7H3ClFNS
Formula Weight
187.62
MOL File
182344-56-5.mol
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2-Chloro-4-fluorobenzothiazole Property

Boiling point:
253.0±13.0 °C(Predicted)
Density 
1.532±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. -20°C
pka
-1.70±0.10(Predicted)
form 
solid
color 
Light yellow to yellow
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Safety

HS Code 
29342000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C584903
Product name
2-Chloro-4-fluorobenzothiazole
Packaging
1g
Price
$280
Updated
2021/12/16
AK Scientific
Product number
W3960
Product name
2-Chloro-4-fluorobenzothiazole
Packaging
5g
Price
$301
Updated
2021/12/16
Matrix Scientific
Product number
072112
Product name
2-Chloro-4-fluorobenzothiazole
Purity
95+%
Packaging
1g
Price
$347
Updated
2021/12/16
Apolloscientific
Product number
PC201182
Product name
2-Chloro-4-fluorobenzo[d]thiazole
Purity
95+%
Packaging
1g
Price
$67
Updated
2021/12/16
AK Scientific
Product number
W3960
Product name
2-Chloro-4-fluorobenzothiazole
Packaging
1g
Price
$101
Updated
2021/12/16
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2-Chloro-4-fluorobenzothiazole Chemical Properties,Usage,Production

Chemical Properties

Pale yellow solid

Synthesis

154327-24-9

182344-56-5

General procedure for the synthesis of 2-chloro-4-fluorobenzothiazole from 2-mercapto-4-fluorobenzothiazole: General method GP3-1: 2-halo-substituted anilines (1.0 eq.) were dissolved in 10 volumes of anhydrous DMF under nitrogen protection with potassium ethylxanthate (1.2 eq. or 2.2 eq., 2.2 eq. was usually used) and the reaction was heated for 4 hr. at 100°C or 120°C. The reaction progress was monitored by TLC. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with 10 volumes of water and neutralized with 1 M HCl solution to pH 5. The resulting precipitate was collected by filtration, washed with water, dried by rotary evaporator and then further dried under an oil pump. General method GP3-2: To a solution of 2-mercaptobenzothiazole in 10 volumes of anhydrous DCM was slowly added sulfuryl chloride (SO2Cl2, 1 volume) under cooling conditions in an ice bath. The reaction mixture was stirred at room temperature for 1 h. The reaction progress was monitored by TLC. After complete consumption of the ingredients, the reaction mixture was diluted with 30 volumes of ether and the reaction was quenched by careful addition of water. Stirring was continued for 1 hour to ensure complete consumption of thionyl chloride and product release. The organic layer was separated, neutralized with saturated NaHCO3 solution, dried over anhydrous Na2SO4 and finally purified by silica gel column chromatography to afford the pure 2-chloro-4-fluorobenzothiazole. The final structure of the product was confirmed by characterization by LC-MS and NMR.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7661 - 7670

2-Chloro-4-fluorobenzothiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloro-4-fluorobenzothiazole manufacturers

Honest Joy Holdings Limited
Product
2-Chloro-4-fluorobenzothiazole 182344-56-5
Price
US $0.00/KG
Min. Order
1KG
Purity
97.5%
Supply Ability
100 tons
Release date
2022-01-14
Career Henan Chemical Co
Product
2-Chloro-4-fluorobenzothiazole 182344-56-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-09

182344-56-5, 2-Chloro-4-fluorobenzothiazoleRelated Search:

2,2'-Dithiobis(benzothiazole) 2-Mercaptobenzothiazole Fluroxypyr Flucloxacillin sodium Benzothiazole Cyhalothrin 2-Chlorobenzothiazole λ-Cyhalothrin 2-Chloro-4,6-difluorobenzothiazole 2-CHLORO-6-FLUOROBENZOTHIAZOLE Difluorochloromethane 2-Amino-6-chloro-4-fluorobenzothiazole 2-Amino-5-chloro-4-fluorobenzothiazole 2-Amino-7-chloro-4-fluorobenzothiazole 2-CHLORO-7-FLUOROBENZOTHIAZOLE 2-CHLORO-5-FLUOROBENZOTHIAZOLE 6-BROMO-2-CHLORO-4-FLUOROBENZOTHIAZOLE 2-Chloro-4,5-difluorobenzothiazole

  • IFLAB-BB F1910-0007
  • 2-CHLORO-4-FLUOROBENZOTHIAZOLE
  • 2-CHLORO-4-FLUORO-1,3-BENZOTHIAZOLE
  • Benzothiazole, 2-chloro-4-fluoro- (9CI)
  • 2-Chloro-4-fluorobenzo[d]thiazole
  • Benzothiazole, 2-chloro-4-fluoro-
  • 182344-56-5
  • BENZOTHIAZOLE