ChemicalBook > CAS DataBase List > Isoconazole nitrate

Isoconazole nitrate

Product Name
Isoconazole nitrate
CAS No.
24168-96-5
Chemical Name
Isoconazole nitrate
Synonyms
Fazol;R 15454;Travogyn;Travogen;Adestan G 100;Gyno-Travogen;Gyno-travozen;ISOCONAZOLE NITRATE;IsoconazoleNitrate>Isosorbide itraconazole
CBNumber
CB5317271
Molecular Formula
C18H15Cl4N3O4
Formula Weight
479.14
MOL File
24168-96-5.mol
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Isoconazole nitrate Property

Melting point:
178-182°C
storage temp. 
Sealed in dry,2-8°C
solubility 
Very slightly soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent).
form 
Solid
color 
White to Off-White
Merck 
14,5160
CAS DataBase Reference
24168-96-5(CAS DataBase Reference)
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Safety

RTECS 
NI4772000
HS Code 
2933.29.4300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2232
Product name
Econazole Impurity D
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500MG
Price
$143
Updated
2024/03/01
Sigma-Aldrich
Product number
I0380000
Product name
Isoconazole nitrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
i0380000
Price
$153
Updated
2024/03/01
TCI Chemical
Product number
I0834
Product name
Isoconazole Nitrate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$88
Updated
2024/03/01
TCI Chemical
Product number
I0834
Product name
Isoconazole Nitrate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$222
Updated
2022/04/27
Cayman Chemical
Product number
30100
Product name
Isoconazole (nitrate)
Packaging
1g
Price
$44
Updated
2024/03/01
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Isoconazole nitrate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Fazol,Fournier,France,1979

Uses

Antibacterial; antifungal

Uses

Isoconazole Nitrate acts as an antibacterial in the local treatment of vaginitis; antifungal agent (1,2).

Manufacturing Process

To a stirred and refluxing solution of 40 parts of benzene and 35 parts of dimethylformamide (both solvents previously dried azeotropically) are added successively 1.6 parts of sodium hydride and 7.7 parts of α-(2,4- dichlorophenyl)imidazole-1-ethanol, (cooling on ice is necessary). After the addition is complete, stirring and refluxing is continued for 30 minutes. Then there are added 7.8 parts of 2.6-dichlorobenzyl chloride and the whole is stirred at reflux for another 3 hours. The reaction mixture is poured onto water and the product 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl] imidazole, is extracted with benzene. The extract is washed twice with water, dried, filtered and evaporated in vacuo. The base residue is dissolved in a mixture of acetone and diisopropyl ether and to this solution is added an excess of concentrated nitric acid solution. The precipitated nitrate salt is filtered off and recrystallized from a mixture of methanol and diisopropyl ether, yielding 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl]imidazole nitrate; melting point 179°C.

Therapeutic Function

Antibacterial, Antifungal

Isoconazole nitrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Isoconazole nitrate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Isoconazole Nitrate 24168-96-5
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-21
Career Henan Chemical Co
Product
Isoconazole nitrate 24168-96-5
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-22

24168-96-5, Isoconazole nitrate Related Search:

(Trifluoromethoxy)benzene Miconazole nitrate Ethanol Ethyl acetate 4-Methoxyphenylacetone Ethylparaben Ethyl cyanoacetate NITRATE Thiamine nitrate p-Anisidine ISOXADIFEN-ETHYL p-(2-Methoxyethyl) phenol Econazole nitrate Dichlorodiphenylsilane Miconazole Nitrate Methoxydiethylborane Dichloromethylphenylsilane Anisole

  • 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1h-imidazole mononitrate
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  • ISOCONAZOLE NITRATE
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  • TIANFU Isoconazole nitrate
  • Miconazole EP Impurity D as Nitrate
  • Miconazole Nitrate EP Impurity D as Nitrate
  • 1-(2-((2,6-Dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole nitrate
  • Isoconazole Nitrate, ≥ 98.0%
  • 24168-96-5
  • 168-96-5
  • C18H14Cl4N2OHNO3C18H15Cl4N3O4
  • C18H14Cl4N20HNO3
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  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Antifungal