Isoconazole nitrate
- Product Name
- Isoconazole nitrate
- CAS No.
- 24168-96-5
- Chemical Name
- Isoconazole nitrate
- Synonyms
- Fazol;R 15454;Travogyn;Travogen;Adestan G 100;Gyno-Travogen;Gyno-travozen;ISOCONAZOLE NITRATE;IsoconazoleNitrate>Isosorbide itraconazole
- CBNumber
- CB5317271
- Molecular Formula
- C18H15Cl4N3O4
- Formula Weight
- 479.14
- MOL File
- 24168-96-5.mol
Isoconazole nitrate Property
- Melting point:
- 178-182°C
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Very slightly soluble in water, soluble in methanol, slightly soluble in ethanol (96 per cent).
- form
- Solid
- color
- White to Off-White
- Merck
- 14,5160
- CAS DataBase Reference
- 24168-96-5(CAS DataBase Reference)
Safety
- RTECS
- NI4772000
- HS Code
- 2933.29.4300
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHR2232
- Product name
- Econazole Impurity D
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500MG
- Price
- $143
- Updated
- 2024/03/01
- Product number
- I0380000
- Product name
- Isoconazole nitrate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- i0380000
- Price
- $153
- Updated
- 2024/03/01
- Product number
- I0834
- Product name
- Isoconazole Nitrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $88
- Updated
- 2024/03/01
- Product number
- I0834
- Product name
- Isoconazole Nitrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $222
- Updated
- 2022/04/27
- Product number
- 30100
- Product name
- Isoconazole (nitrate)
- Packaging
- 1g
- Price
- $44
- Updated
- 2024/03/01
Isoconazole nitrate Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Fazol,Fournier,France,1979
Uses
Antibacterial; antifungal
Uses
Isoconazole Nitrate acts as an antibacterial in the local treatment of vaginitis; antifungal agent (1,2).
Manufacturing Process
To a stirred and refluxing solution of 40 parts of benzene and 35 parts of dimethylformamide (both solvents previously dried azeotropically) are added successively 1.6 parts of sodium hydride and 7.7 parts of α-(2,4- dichlorophenyl)imidazole-1-ethanol, (cooling on ice is necessary). After the addition is complete, stirring and refluxing is continued for 30 minutes. Then there are added 7.8 parts of 2.6-dichlorobenzyl chloride and the whole is stirred at reflux for another 3 hours. The reaction mixture is poured onto water and the product 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl] imidazole, is extracted with benzene. The extract is washed twice with water, dried, filtered and evaporated in vacuo. The base residue is dissolved in a mixture of acetone and diisopropyl ether and to this solution is added an excess of concentrated nitric acid solution. The precipitated nitrate salt is filtered off and recrystallized from a mixture of methanol and diisopropyl ether, yielding 1-[2,4-dichloro-b-(2,6-dichlorobenzyloxy)phenethyl]imidazole nitrate; melting point 179°C.
Therapeutic Function
Antibacterial, Antifungal
Isoconazole nitrate Preparation Products And Raw materials
Raw materials
Preparation Products
Isoconazole nitrate Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from Isoconazole nitrate manufacturers
- Product
- Isoconazole Nitrate 24168-96-5
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-11-21
- Product
- Isoconazole nitrate 24168-96-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-22