ChemicalBook > CAS DataBase List > 3-Nitrophthalic acid
3-Nitrophthalic acid
- Product Name
- 3-Nitrophthalic acid
- CAS No.
- 603-11-2
- Chemical Name
- 3-Nitrophthalic acid
- Synonyms
- 3-NPA;o-Nitrophthalic acid;Pomalidomide Impurity 8;3-nitro-1,2-benzenedicarboxylic acid;NSC 3120;AKOS B028734;3-nitrophthalic;3-nitro-phthalate;RARECHEM AL BO 0803;m-Nitrophthalic acid
- CBNumber
- CB5323089
- Molecular Formula
- C8H5NO6
- Formula Weight
- 211.13
- MOL File
- 603-11-2.mol
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3-Nitrophthalic acid Property
- Melting point:
- 210 °C (dec.) (lit.)
- Boiling point:
- 350.79°C (rough estimate)
- Density
- 1.6342 (rough estimate)
- vapor density
- 7.3 (vs air)
- refractive index
- 1.5282 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- water: soluble5%, clear to slightly hazy, colorless to faint yellow or tan
- pka
- pK1:1.88 (25°C)
- form
- Powder
- color
- Off-white to light yellow
- Water Solubility
- 20 g/L (25 ºC)
- Decomposition
- 216 °C
- BRN
- 2054269
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- KFIRODWJCYBBHY-UHFFFAOYSA-N
- CAS DataBase Reference
- 603-11-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 3-Nitrophthalic acid(603-11-2)
- EPA Substance Registry System
- 3-Nitrophthalic acid (603-11-2)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-41
- Safety Statements
- 26-36/39-37/39-36
- WGK Germany
- 3
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29173980
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 369306
- Product name
- 3-Nitrophthalic acid
- Purity
- 95%
- Packaging
- 100g
- Price
- $58.04
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 137820
- Product name
- 3-Nitrophthalic acid
- Purity
- 99%
- Packaging
- 100g
- Price
- $149
- Updated
- 2025/07/31
TCI Chemical
- Product number
- N0243
- Product name
- 3-Nitrophthalic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $31
- Updated
- 2025/07/31
TCI Chemical
- Product number
- N0243
- Product name
- 3-Nitrophthalic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 500g
- Price
- $140
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 8.00649
- Product name
- 3-Nitrophthalic acid for synthesis. CAS No. 603-11-2, EC Number 210-030-8., for synthesis
- Packaging
- 8006490100
- Price
- $74.1
- Updated
- 2021/12/16
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3-Nitrophthalic acid Chemical Properties,Usage,Production
Chemical Properties
Pale yellow crystals. soluble in hot water, methanol, ethanol, slightly soluble in ether, insoluble in chloroform, carbon tetrachloride, carbon disulfide, benzene.
Uses
3-Nitrophthalic Acid is a useful chemical in organic synthesis. It is also an impurity of Apremilast.
Uses
3-Nitrophthalic acid may be used as starting reagent in the synthesis of modified 2-iodoxybenzoic acid derivatives. It may be used in the synthesis of brucinium 2-carboxy-6-nitrophthalate dihydrate (systematic name: 2,3-dimethoxy-10-oxostrychnidinium 2-carboxy-6-nitrophthalate dihydrate), via heating with brucine.
Preparation
Phthalic anhydride was added to concentrated sulfuric acid, stirring under the passage of water vapor heating to 80 °C, fuming nitric acid was added dropwise, the reaction temperature to maintain 100-110°C, add the end of the heat above 110°C for 2h, placed in the overnight pour into the water, and filtered. The filter cake was recrystallized with water to obtain 3-Nitrophthalic acid. Yield of about 30%.
Synthesis Reference(s)
The Journal of Organic Chemistry, 39, p. 2468, 1974 DOI: 10.1021/jo00930a051
General Description
3-Nitrophthalic acid is a degradation product of isoxaben herbicide. It acts as ligand and forms rare-earth complexes.
Safety Profile
A preparative hazard. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Crystallise 3-nitrophthalic acid from hot water (1.5mL/g). Dry it in air. The amide has m 201o (from EtOH). [Beilstein 9 H 823, 9 IV 3275.]
3-Nitrophthalic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Nitrophthalic acid manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 3-Nitrophthalic acid 603-11-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-08
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
- Product
- 3-Nitrophthalic acid 603-11-2
- Price
- US $999.00-666.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-20
Hebei Zhuanglai Chemical Trading Co Ltd
- Product
- 3-Nitrophthalic acid 603-11-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-27
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