Aminooxy-PEG4-alcohol

Product Name: Aminooxy-PEG4-alcohol
CAS No.: 106492-60-8
Chemical Name: Aminooxy-PEG4-alcohol
Synonyms: HO-PEG4-ONH2;Aminooxy-PEG4-alcohol;Hydroxylamine-tetraethylene glycol;2-(2-(2-(2-(aminooxy)ethoxy)ethoxy)ethoxy)ethanol;Ethanol, 2-[2-[2-[2-(aminooxy)ethoxy]ethoxy]ethoxy]-;Aminooxy PEG4 alcohol,AminooxyPEG4alcohol,Aminooxy-PEG-4-alcohol
CBNumber: CB53373559
Molecular Formula: C8H19NO5
Formula Weight: 209.24
MOL File: 106492-60-8.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23671
Product name: Aminooxy-PEG4-alcohol
Purity: 98%
Packaging: 250mg
Price: $580
Updated: 2021/12/16

BroadPharm

Product number: BP-23671
Product name: Aminooxy-PEG4-alcohol
Purity: 98%
Packaging: 500mg
Price: $820
Updated: 2021/12/16

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Aminooxy-PEG4-alcohol Chemical Properties,Usage,Production

Description

Aminooxy-PEG4-alcohol is an aqueous soluble PEG reagent. The aminooxy group can react with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

Uses

Aminooxy-PEG4-alcohol is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG4-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

IC 50

PEGs; Non-cleavable Linker

References

[1] Heather D. Maynard, et al. Method of creating hydrogels through oxime bond formation. US20150202305A1.
[2] Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb). 2010 Dec 7;46(45):8651-3. DOI:10.1039/c0cc03856c

Aminooxy-PEG4-alcohol Preparation Products And Raw materials

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View Lastest Price from Aminooxy-PEG4-alcohol manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Aminooxy-PEG4-alcohol 106492-60-8
Price: US $0.00/mg
Min. Order: 250mg
Purity: >98.00%
Supply Ability: 250mg
Release date: 2024-03-22

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Aminooxy-PEG4-alcohol

Ethanol, 2-[2-[2-[2-(aminooxy)ethoxy]ethoxy]ethoxy]-

2-(2-(2-(2-(aminooxy)ethoxy)ethoxy)ethoxy)ethanol

Aminooxy PEG4 alcohol,AminooxyPEG4alcohol,Aminooxy-PEG-4-alcohol

HO-PEG4-ONH2

Hydroxylamine-tetraethylene glycol

106492-60-8