Aminooxy-PEG2-alcohol
- Product Name
- Aminooxy-PEG2-alcohol
- CAS No.
- 185022-12-2
- Chemical Name
- Aminooxy-PEG2-alcohol
- Synonyms
- Aminooxy-PEG2-alcohol;2-(2-(aminooxy)ethoxy)ethanol;Ethanol, 2-[2-(aminooxy)ethoxy]-
- CBNumber
- CB63162831
- Molecular Formula
- C4H11NO3
- Formula Weight
- 121.14
- MOL File
- 185022-12-2.mol
Aminooxy-PEG2-alcohol Property
- Boiling point:
- 265.9±20.0 °C(Predicted)
- Density
- 1.116±0.06 g/cm3(Predicted)
- pka
- 14.39±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8191CZ
- Product name
- Aminooxy-PEG2-alcohol
- Packaging
- 100mg
- Price
- $453
- Updated
- 2021/12/16
- Product number
- BP-23251
- Product name
- Aminooxy-PEG2-alcohol
- Purity
- 98%
- Packaging
- 250mg
- Price
- $540
- Updated
- 2021/12/16
Aminooxy-PEG2-alcohol Chemical Properties,Usage,Production
Description
Aminooxy-PEG2-alcohol is a short PEG linker containing an aminooxy group and a a hydroxyl group. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
Uses
Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
IC 50
PEGs; Non-cleavable Linker
References
[1] Marek Kwiatkowski. Conjugates of biologically active molecules to functionalized polymers. WO2013186632A2.
[2] Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb). 2010 Dec 7;46(45):8651-3. DOI:10.1039/c0cc03856c
Aminooxy-PEG2-alcohol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Aminooxy-PEG2-alcohol manufacturers
- Product
- Aminooxy-PEG2-alcohol 185022-12-2
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-22