2-Chloro-5-fluoropyrimidine

ChemicalBook > CAS DataBase List > 2-Chloro-5-fluoropyrimidine

2-Chloro-5-fluoropyrimidine

Product Name: 2-Chloro-5-fluoropyrimidine
CAS No.: 62802-42-0
Chemical Name: 2-Chloro-5-fluoropyrimidine
Synonyms: 2-Chloro-5-fluoropyr;Fampridine Impurity 213;2-CHLORO-5-FLUOROPYRIMIDINE;2-Chloro-5-fluoropyriMidi...;Pyrimidine,2-chloro-5-fluoro-;2-Chloro-5-fluoro-1,3-diazine;2-Chloro-5-fluoropyrimidine >2-Chloro-5-fluoropyrimidine ,98%;Pyrimidine, 2-chloro-5-fluoro- (9CI);2-Chloro-5-fluoropyrimidine ISO 9001：2015 REACH
CBNumber: CB5343151
Molecular Formula: C4H2ClFN2
Formula Weight: 132.52
MOL File: 62802-42-0.mol

Less

2-Chloro-5-fluoropyrimidine Property

Boiling point:: 149.0-162.0°C
Density: 1.439 g/mL at 20 °C (lit.)
refractive index: n20/D 1.503(lit.)
Flash point:: 150 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Liquid
pka: -2.54±0.22(Predicted)
color: Clear colorless to yellow
InChI: InChI=1S/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H
InChIKey: AGYUQBNABXVWMS-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(F)C=N1
CAS DataBase Reference: 62802-42-0(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-34-41-37/38
Safety Statements: 26-36/37/39-45
RIDADR: UN 2735 8/PG 2
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 29335990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 651753
Product name: 2-Chloro-5-fluoropyrimidine
Purity: 97%
Packaging: 1g
Price: $183
Updated: 2023/06/20

Sigma-Aldrich

Product number: 651753
Product name: 2-Chloro-5-fluoropyrimidine
Purity: 97%
Packaging: 250mg
Price: $86.8
Updated: 2023/01/07

TCI Chemical

Product number: C2546
Product name: 2-Chloro-5-fluoropyrimidine
Purity: >98.0%(GC)
Packaging: 1g
Price: $50
Updated: 2024/03/01

TCI Chemical

Product number: C2546
Product name: 2-Chloro-5-fluoropyrimidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $149
Updated: 2024/03/01

Alfa Aesar

Product number: H55055
Product name: 2-Chloro-5-fluoropyrimidine, 97%
Packaging: 1g
Price: $144.65
Updated: 2024/03/01

Less

2-Chloro-5-fluoropyrimidine Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liquid

Uses

2-Chloro-5-fluoropyrimidine is used to prepare 2,4-disubstituted-5-fluoropyrimidine , which is a biologically active molecule seen in anticancer agents like 5-fluorouracil.

Uses

2-Chloro-5-fluoropyrimidine can be used as a starting material for the preparation of:
5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K2CO3, via C-N bond forming reaction.
2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate, which is used in the synthesis of benzamide scaffolds as potent antagonists against P2X7 receptors.
5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, as a potent inhibitor of the JAK2 kinase.

Preparation

Synthesis of 2-chloro-5-fluoropyrimidine: add 2,4-Dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, stir to raise the temperature to the reaction temperature, slowly add acid dropwise, and keep the temperature until the reaction is completed Finish. Filtration, phase separation or direct evaporation of the solvent, and distillation under reduced pressure to remove the solvent to obtain 2-chloro-5-fluoropyrimidine.

2-Chloro-5-fluoropyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-Chloro-5-fluoropyrimidine Suppliers

Americas 1 Canada 4 China 285 Europe 3 Germany 1 India 8 Italy 1 Japan 1 Switzerland 1 United Kingdom 12 United States 45 Global 362

Taizhou FRIEND Chemical Co., Ltd.

Tel: 0523-86200082 15380713688
Fax: 0523-86200991
Email: Austin@fredchem.cn
Country: China
ProdList: 205
Advantage: 55

Jiangsu Mingchem Corporation

Tel: 0519-85170101
Fax: 0519-85170505
Email: sales@mingchem.com
Country: China
ProdList: 609
Advantage: 55

Weifang Yuda Pharmaceutical Technology Co., Ltd.

Tel: 17663603912
Fax: +86-536- 8637276
Email: 2710256076@qq.com
Country: China
ProdList: 191
Advantage: 56

Jiangsu Zhongyuan Chemicals Co.,Ltd.

Tel: 0513-84539538 13817775327
Email: jinjing860329@163.com
Country: China
ProdList: 19
Advantage: 58

Win-Win Chemical CO., Limited

Tel: 0577-64498589 15325081899
Fax: 0577-56994596
Email: sales@win-winchemical.com
Country: China
ProdList: 1121
Advantage: 58

Liyang Kunlu biological technology co.,ltd

Tel: 0519-87310015 13813530041
Fax: 0519-87310015
Email: 200601296@qq.com
Country: China
ProdList: 173
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40240
Advantage: 62

Liaoning Tianhua Chemical Co., Ltd.

Tel: 0418-6530555 2855550
Fax: +86-418-6502885
Country: China
ProdList: 338
Advantage: 69

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Carbott PharmTech Inc.

Tel: 0535-6385396
Fax: +86 (535) 638-9971
Email: info@carbottpharm.com
Country: China
ProdList: 870
Advantage: 56

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35906
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12458
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9984
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9551
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11660
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel
Country: China
ProdList: 42982
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15421
Advantage: 60

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4271
Advantage: 65

BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11726
Advantage: 57

China Langchem Inc.

Tel: 021-58956006 15800617331
Fax: 021-58956100
Email: sales@langchem.com
Country: China
ProdList: 211
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14443
Advantage: 57

Shanghai AmasPharm Co., Ltd.

Tel: 021-54540637 18621091017
Fax: 021-34978309
Email: sales@amaspharm.com
Country: China
ProdList: 679
Advantage: 62

Nanjing Vital Chemical Co., Ltd.

Tel: Please Send Email 18652950785
Fax: 025-87193546
Email: chemweiao@163.com
Country: China
ProdList: 4388
Advantage: 65

Changzhou Book Chemical Co., Ltd.

Tel: 13775119556
Fax: 0519-68780180
Email: bookchem@126.com
Country: China
ProdList: 552
Advantage: 62

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 15343847665
Fax: QQ：3470079902
Email: huawenchem@163.com
Country: China
ProdList: 3205
Advantage: 55

Wisdom Pharmaceutical Co., Ltd.

Tel: 0086-15189180296
Fax: 0086-513-81292226
Email: l_xu@wisdompharma.com
Country: China
ProdList: 221
Advantage: 60

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9872
Advantage: 52

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1927
Advantage: 55

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17779
Advantage: 75

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9452
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19918
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 18017383231 18017383231
Fax: qq：2817624287
Email: lyh_antaeus@163.com
Country: China
ProdList: 9352
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18216
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25014
Advantage: 65

Shanghai Arbor Chemical Co., Ltd.

Tel: 021-021-60451683 15021268886
Fax: +86-21-60451682
Email: sales@arborchemical.com
Country: China
ProdList: 922
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9906
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7876
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8033
Advantage: 55

Zouping Mingxing Chemical Co.,Ltd.

Tel: 86-13605431940 13605431940
Fax: 0086-0543-2240079
Email: zpmxchemical@126.com
Country: China
ProdList: 2002
Advantage: 62

Wuxi Zhangkun Biochemical Technology Co., Ltd.

Tel: +86 0510-85629785
Fax: +86 0510-85625359
Country: China
ProdList: 2331
Advantage: 58

Shanghai Hekang Biotechnology Co., Ltd.

Tel: 18939837085
Fax: 2880152141(QQ)
Email: youchemicals@gmail.com
Country: China
ProdList: 1813
Advantage: 55

Huainan Kedi Chemical Factory

Tel: 0554-2106669
Fax: 0554-2666215
Email: sales1@kedichem.com
Country: China
ProdList: 4928
Advantage: 55

Megchem Co., Ltd.

Tel: +86 (21) 5471-7132
Fax: +86 (21) 5471-6993
Country: China
ProdList: 345
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41438
Advantage: 60

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Country: China
ProdList: 2931
Advantage: 58

Less

View Lastest Price from 2-Chloro-5-fluoropyrimidine manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Chloro-5-fluoropyrimidine 62802-42-0
Price: US $35.00-1.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-17

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-5-fluoropyrimidine 62802-42-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Chloro-5-fluoropyrimidine 62802-42-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-22

62802-42-0, 2-Chloro-5-fluoropyrimidineRelated Search:

Cyhalothrin 5-Fluoropyrimidine Fluorocytosine 2-Chloropyrimidine 2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE 2,4-DICHLORO-6-ETHYL-5-FLUOROPYRIMIDINE 4-AMINO-2-CHLORO-5-FLUOROPYRIMIDINE,4-AMINO-2-CHLORO-5-FLUOROPYRIMIDINE GC 95.0%,2-Chloro-5-fluoropyrimidine-4-amine 2,4-Dichloro-5-fluoropyrimidine Difluorochloromethane 3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine Pyrimidine, 4-chloro-6-fluoro- (9CI) (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 2-Fluoro-3,5-dichloropyridine 4,6-Dichloro-5-fluoropyrimidine 3-(6-Chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride 4-(1-bromoethyl)-6-chloro-5-fluoropyrimidine CHEMBRDG-BB 4015094

Pyrimidine, 2-chloro-5-fluoro- (9CI)

2-CHLORO-5-FLUOROPYRIMIDINE

Pyrimidine,2-chloro-5-fluoro-

2-Chloro-5-fluoropyr

2-Chloro-5-fluoropyriMidi...

2-Chloro-5-fluoropyrimidine ,98%

2-Chloro-5-fluoro-1,3-diazine

2-Chloro-5-fluoropyrimidine &gt

2-Chloro-5-fluoropyrimidine ISO 9001：2015 REACH

Fampridine Impurity 213

62802-42-0

63802-42-0

C4H2ClFN2

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyrimidines

Fluorine series

Bases & Related Reagents

Nucleotides

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

PyrimidinesHeterocyclic Building Blocks

Variety of halogenated heterocyclic series

PYRIMIDINE

Pyrimidine series

pharmacetical

Pyrimidines

62802-42-0