2-Chloro-5-fluoropyrimidine
- Product Name
- 2-Chloro-5-fluoropyrimidine
- CAS No.
- 62802-42-0
- Chemical Name
- 2-Chloro-5-fluoropyrimidine
- Synonyms
- 2-Chloro-5-fluoropyr;Fampridine Impurity 213;2-CHLORO-5-FLUOROPYRIMIDINE;2-Chloro-5-fluoropyriMidi...;Pyrimidine,2-chloro-5-fluoro-;2-Chloro-5-fluoro-1,3-diazine;2-Chloro-5-fluoropyrimidine >2-Chloro-5-fluoropyrimidine ,98%;Pyrimidine, 2-chloro-5-fluoro- (9CI);2-Chloro-5-fluoropyrimidine ISO 9001：2015 REACH
- CBNumber
- CB5343151
- Molecular Formula
- C4H2ClFN2
- Formula Weight
- 132.52
- MOL File
- 62802-42-0.mol
2-Chloro-5-fluoropyrimidine Property
- Boiling point:
- 149.0-162.0°C
- Density
- 1.439 g/mL at 20 °C (lit.)
- refractive index
- n20/D 1.503(lit.)
- Flash point:
- 150 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Liquid
- pka
- -2.54±0.22(Predicted)
- color
- Clear colorless to yellow
- InChI
- InChI=1S/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H
- InChIKey
- AGYUQBNABXVWMS-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(F)C=N1
- CAS DataBase Reference
- 62802-42-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-34-41-37/38
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 2735 8/PG 2
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 651753
- Product name
- 2-Chloro-5-fluoropyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $183
- Updated
- 2023/06/20
- Product number
- 651753
- Product name
- 2-Chloro-5-fluoropyrimidine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $86.8
- Updated
- 2023/01/07
- Product number
- C2546
- Product name
- 2-Chloro-5-fluoropyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $50
- Updated
- 2024/03/01
- Product number
- C2546
- Product name
- 2-Chloro-5-fluoropyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $149
- Updated
- 2024/03/01
- Product number
- H55055
- Product name
- 2-Chloro-5-fluoropyrimidine, 97%
- Packaging
- 1g
- Price
- $144.65
- Updated
- 2024/03/01
2-Chloro-5-fluoropyrimidine Chemical Properties,Usage,Production
Chemical Properties
Colorless to light yellow liquid
Uses
2-Chloro-5-fluoropyrimidine is used to prepare 2,4-disubstituted-5-fluoropyrimidine , which is a biologically active molecule seen in anticancer agents like 5-fluorouracil.
Uses
2-Chloro-5-fluoropyrimidine can be used as a starting material for the preparation of:
5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K2CO3, via C-N bond forming reaction.
2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate, which is used in the synthesis of benzamide scaffolds as potent antagonists against P2X7 receptors.
5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, as a potent inhibitor of the JAK2 kinase.
Preparation
Synthesis of 2-chloro-5-fluoropyrimidine: add 2,4-Dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, stir to raise the temperature to the reaction temperature, slowly add acid dropwise, and keep the temperature until the reaction is completed Finish. Filtration, phase separation or direct evaporation of the solvent, and distillation under reduced pressure to remove the solvent to obtain 2-chloro-5-fluoropyrimidine.
References
[1] A. Dunaiskis. “LARGE SCALE SYNTHESIS OF 2-CHLORO-5-FLUOROPYRIMIDINE.” Organic Preparations and Procedures International 27 1 (1995): 600–602.
[2] A. DUNAISKIS. “ChemInform Abstract: Large Scale Synthesis of 2-Chloro-5-fluoropyrimidine.” ChemInform 26 52 (1995).
2-Chloro-5-fluoropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-5-fluoropyrimidine Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from 2-Chloro-5-fluoropyrimidine manufacturers
- Product
- 2-Chloro-5-fluoropyrimidine 62802-42-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-22
- Product
- 2-Chloro-5-fluoropyrimidine 62802-42-0
- Price
- US $35.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-17
- Product
- 2-Chloro-5-fluoropyrimidine 62802-42-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26