2,3,4,6-TETRAFLUORONITROBENZENE
- Product Name
- 2,3,4,6-TETRAFLUORONITROBENZENE
- CAS No.
- 314-41-0
- Chemical Name
- 2,3,4,6-TETRAFLUORONITROBENZENE
- Synonyms
- 2,3,4,6-TetrafL;2,3,4,6-TETRAFLUORON;5-fluro-2-methylaniline;5-tetrafluoro-4-nitrobenzene;2,3,4,6-TETRAFLUORONITROBENZENE;1,2,4,6-Tetrafluoronitrobenzene;2-Nitro-1,3,4,5-tetrafluorobenzene;1,2,3,5-Tetrafluoro-4-nitrobenzene;2,3,4,6-Tetrafluoronitrobenzene98%;1-Nitro-2,3,4,6-tetrafluorobenzene
- CBNumber
- CB5351352
- Molecular Formula
- C6HF4NO2
- Formula Weight
- 195.07
- MOL File
- 314-41-0.mol
2,3,4,6-TETRAFLUORONITROBENZENE Property
- Melting point:
- -5
- Boiling point:
- 78-79°C 20mm
- Density
- 1.511 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.464(lit.)
- Flash point:
- 160 °F
- storage temp.
- 2-8°C
- form
- liquid
- Specific Gravity
- 1.511
- Appearance
- Colorless to light yellow Liquid
- Stability:
- Stable. Incompatible with strong oxidizing agents, strong bases. Combustible.
- CAS DataBase Reference
- 314-41-0(CAS DataBase Reference)
- EPA Substance Registry System
- Benzene, 1,2,3,5-tetrafluoro-4-nitro- (314-41-0)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P991955
- Product name
- 2,3,4,6-Tetrafluoronitrobenzene
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- J99957
- Product name
- 2,3,4,6-Tetrafluoronitrobenzene
- Packaging
- 1g
- Price
- $89
- Updated
- 2021/12/16
- Product number
- PC6810
- Product name
- 2,3,4,6-Tetrafluoronitrobenzene
- Purity
- 97%
- Packaging
- 1g
- Price
- $119
- Updated
- 2021/12/16
- Product number
- 4654-3-14
- Product name
- 2,3,4,6-Tetrafluoronitrobenzene
- Purity
- 97%
- Packaging
- 1g
- Price
- $132
- Updated
- 2021/12/16
- Product number
- PC6810
- Product name
- 2,3,4,6-Tetrafluoronitrobenzene
- Purity
- 97%
- Packaging
- 5g
- Price
- $203
- Updated
- 2021/12/16
2,3,4,6-TETRAFLUORONITROBENZENE Chemical Properties,Usage,Production
Chemical Properties
yellow liquid
General Description
Molluscicidal activity of 2,3,4,6-tetrafluoronitrobenzene against Biomphalaria glabrata has been investigated. Palladium-catalyzed cross-coupling reactions of 2,3,4,6-tetrafluoronitrobenzene with alkyne derivatives has been studied. Reaction of 2,3,4,6-tetrafluoronitrobenzene with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene in the presence of water molecules in acetonitrile has been investigated.
Synthesis
2367-82-0
314-41-0
For the large-scale synthesis of 1,2,3,5-tetrafluoro-4-nitrobenzene, a mixed solution of concentrated nitric acid (990 g) in concentrated sulfuric acid (973 mL) was first pre-cooled, and then the mixed solution was slowly added to a cold solution of 1,2,3,5-tetrafluorobenzene (973.1 g) dissolved in concentrated sulfuric acid (2,920 mL) at temperatures ranging from 0 °C to 10 °C, with the addition process being controlled to be completed within 1.5 The addition process was completed within 1.5 hours. After the addition was completed, the reaction temperature was maintained between 0 °C and 10 °C, and the yellow reaction solution was continued to be stirred for 1 hour until the analysis confirmed the completion of the reaction. Subsequently, the reaction solution was slowly poured into water (9730 g) that had been pre-cooled to below 25 °C, and dichloromethane (9730 mL) was added for extraction. After separation of the organic phase, it was washed twice with deionized water (10 L). The dichloromethane layer was concentrated to give a yellow oil. Finally, the oily substance was distilled under reduced pressure (2.5 mbar) at 70 °C to 75 °C to give a yellow oily product with 98% purity and 72.4% yield.
References
[1] Journal of Organic Chemistry, 1995, vol. 60, # 22, p. 7348 - 7350
[2] Patent: US2012/316149, 2012, A1. Location in patent: Page/Page column 11
[3] Patent: WO2012/168884, 2012, A1. Location in patent: Page/Page column 26; 27
[4] Russian Chemical Bulletin, 1998, vol. 47, # 5, p. 924 - 927
[5] Journal of the American Chemical Society, 1951, vol. 73, p. 153
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