ChemicalBook > CAS DataBase List > GANODERIC ACID DM

GANODERIC ACID DM

Product Name: GANODERIC ACID DM
CAS No.: 173075-45-1
Chemical Name: GANODERIC ACID DM
Synonyms: Gaderic acid DM;GANODERIC ACID DM;(24E)-3,7-Dioxolanosta-8,24-dien-26-oic acid;Lanosta-8,24-dien-26-oic acid, 3,7-dioxo-, (24E)-;(R,E)-2-methyl-6-((5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-3,7-dioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)hept-2-enoic acid
CBNumber: CB5354656
Molecular Formula: C30H44O4
Formula Weight: 468.67
MOL File: 173075-45-1.mol

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GANODERIC ACID DM Property

storage temp.: -20°C
solubility: Methanol: soluble
form: Powder
color: White to off-white
InChIKey: ZTKZZRIVAYGFSF-PIPDTRPPSA-N
SMILES: C1(=O)[C@@]([C@]2([C@](C)(CC1)C1=C([C@]3([C@@](CC1)(C)[C@@H]([C@H](C)CC/C=C(\C)/C(O)=O)CC3)C)C(=O)C2)[H])(C)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Arctom

Product number: CFN99815
Product name: GanodericacidDM
Purity: ≥98%
Packaging: 5mg
Price: $592
Updated: 2021/12/16

Crysdot

Product number: CD32002224
Product name: GanodericacidDM
Purity: 95+%
Packaging: 5mg
Price: $930
Updated: 2021/12/16

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GANODERIC ACID DM Chemical Properties,Usage,Production

Uses

Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[1][2].

Definition

ChEBI: Ganoderic acid DM is a triterpenoid.

Biological Activity

Ganoderic acid DM is a triterpenoid that has been found in G. lucidum and has diverse biological activities. 1,2,3 It inhibits 5α-reductase and HMG-CoA reductase (IC50s = 10.6 and 9.5 μM, respectively) and binds to the ligand-binding domain of the androgen receptor in a fluorescence polarization assay.1,2 Ganoderic acid suppresses osteoclastogenesis of RAW 264.7 cells when used at a concentration of 12.5 μM and is cytotoxic to K562 leukemia and PC3 prostate cancer cells (IC50s = 18.8 and 81.6 μM, respectively). It reduces ear edema induced by phorbol 12-myristate 13-acetate in mice (ID50 = 0.08 mg/ear).3

References

1.Liu, J., Shiono, J., Shimizu, K., et al.Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitorBioorg. Med. Chem. Lett.19(8)2154-2157(2009) 2.Wang, K., Bao, L., Xiong, W., et al.Lanostane triterpenes from the Tibetan medicinal mushroom Ganoderma leucocontextum and their inhibitory effects on HMG-CoA reductase and α?glucosidaseJ. Nat. Prod.78(8)1977-1989(2015) 3.Akihisa, T., Nakamura, Y., Tagata, M., et al.Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidumChem. Biodivers.4(2)224-231(2007)

GANODERIC ACID DM Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GANODERIC ACID DM manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Ganoderic acid DM 173075-45-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-04-08

173075-45-1, GANODERIC ACID DMRelated Search:

Ganoderic acid D Ganoderic acid N (24E)-3-Oxo-5α-lanosta-7,9(11),24-triene-26-al Ganoderic acid C6 beta-Sitosterol Artemether MOSLOFLAVONE 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one hydroxygenkwanin alpha-Cyperone Hydroxyecdysone alpha-Terpineol beta-Eudesmol (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one Ganoderma spore powder Reish Mushroom P.E Polysaccharide 15% UV GANODERIC ACID A BETA-CYCLOCITRAL

GANODERIC ACID DM

Gaderic acid DM

Lanosta-8,24-dien-26-oic acid, 3,7-dioxo-, (24E)-

(R,E)-2-methyl-6-((5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-3,7-dioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)hept-2-enoic acid

(24E)-3,7-Dioxolanosta-8,24-dien-26-oic acid

173075-45-1

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