SB 431542

Product Name: SB 431542
CAS No.: 301836-41-9
Chemical Name: SB 431542
Synonyms: CS-89;SB 431542;SB 431542, >=98%;SB 431542 HYDRATE;SB-431542/SB431542;SB 431542USP/EP/BP;TGF-β RI Kinase Inhibitor VI, SB431542;TGF-β RI Kinase Inhibitor VI SB431542 SB-431542;InSolution? TGF-β RI Kinase Inhibitor VI, SB431542;4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imid
CBNumber: CB5360318
Molecular Formula: C22H16N4O3
Formula Weight: 384.39
MOL File: 301836-41-9.mol

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SB 431542 Property

Melting point:: 214 °C(dec.)
Boiling point:: 662.4±55.0 °C(Predicted)
Density: 1.373
Flash point:: 354.4℃
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: 10 mg/mL, soluble
form: powder
pka: 10.14±0.10(Predicted)
color: Yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey: FHYUGAJXYORMHI-UHFFFAOYSA-N

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 616464
Product name: InSolution? TGF-β RI Kinase Inhibitor VI, SB431542
Packaging: 5mg
Price: $159
Updated: 2024/03/01

Sigma-Aldrich

Product number: 616461
Product name: TGF-β RI Kinase Inhibitor VI, SB431542
Packaging: 5mg
Price: $176
Updated: 2024/03/01

TCI Chemical

Product number: B4003
Product name: SB 431542
Packaging: 25MG
Price: $241
Updated: 2024/03/01

TCI Chemical

Product number: B4003
Product name: SB 431542
Packaging: 100MG
Price: $662
Updated: 2024/03/01

Cayman Chemical

Product number: 13031
Product name: SB 431542
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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SB 431542 Chemical Properties,Usage,Production

Description

SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 94 nM). It is a less potent antagonist of ALK4 (IC₅₀ = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer. Through its effects on ALK/Smad signaling, SB-431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.

Uses

SB 431542 is a known Src family kinase inhibitor that effectively blocks the transforming growth factor-β1-induced cell migration and invasion in both established and primary carcinoma cells. Potent TGF-beta inhibitor.

Definition

ChEBI: A member of the class of benzamides that is 4-(imidazol-2-yl)benzamide carrying additional 1,3-benzodioxol-5-yl and pyridin-2-yl substituents at positions 4 and 5 respectively on the imidazole ring.

General Description

A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 μM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-β in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6. When tested directly in cell-free kinase assays, SB431542 is demonstrated to potently inhibit the activity of ALK4 and ALK5 (IC₅₀ = 140 nM and 94 nM, respectively) with no or much reduced potency toward a panel of 24 other kinases (IC₅₀ ≥10 μM in the presence of 10 μM ATP), including ALK2 and ALK6. Reported to improve the efficiency of 4-TF-induced human iPSCs generation from fibroblast cultures by >200-fold when used together with PD0325901 (Cat. No. 444966) and Thiazovivin (Cat. No. 420220).

Biological Activity

Potent and selective inhibitor of the transforming growth factor- β (TGF- β ) type I receptor activin receptor-like kinase ALK5 (IC 50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF- β -induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells.

Biochem/physiol Actions

SB-431542 inhibits the TGF-β-mediated activation of SMAD proteins, expression of collagen and fibronectin, cell proliferation and cell motility. It does not inhibit kinases that are activated in response to serum or stress such as ERK, p38 or JNK.

storage

Room temperature

References

1) Laping et al. (2002), Inhibition of transforming growth factor (TGF-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I kinase activity: SB-431542; Mol. Pharmacol., 62 58 2) Inman et al. (2002), SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5 and ALK7; Mol. Pharmacol., 62 65 3) Matsuyama et al. (2003), SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells; Cancer Res., 63 7791 4) Watabe et al. (2003), TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells; J. Cell Biol., 163 1303 5) Stanslowsky et al. (2014), Functional differentiation of midbrain neurons from human cord blood-derived induced pluripotent stem cells; Stem Cell Res. Ther., 5 35

SB 431542 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB 431542 Suppliers

Americas 1 Canada 1 China 170 Europe 1 Germany 2 India 3 Japan 1 Switzerland 1 United Kingdom 4 United States 21 Global 205

Dezhou LonWel Pharmaceutical Technology Co., Ltd.

Tel: 13761310616
Fax: QQ: 39324283
Email: 39324283@qq.com
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Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
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AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
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Shanghai Boyle Chemical Co., Ltd.

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J & K SCIENTIFIC LTD.

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Chembest Research Laboratories Limited

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Ascent Scientific

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VDM Biochemicals

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Nanjing Chemlin Chemical Co., Ltd

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301836-41-9, SB 431542Related Search:

Benzoxazole SB-505124 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline Y27632 (hydrochloride) PD 0325901 MG-132 LDN-193189 LY 294002 HYDROCHLORIDE CHIR-99021 Ispinesib 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride SB242235 SB 203580 SB-705498 4'-CHLORO-3-METHOXYCINNAMANILIDE SB1317 SB 269970 HYDROCHLORIDE 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime

SB-431542/SB431542

SB 431542, >=98%

4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide SB431542

SB 431542 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide

4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate

SB 431542

4-(5-BENZOL[1,3]DIOXOL-5-YL-4-PYRLDIN-2-YL-1H-IMIDAZOL-2-YL)-BENZAMIDE

4-[4-(3,4-METHYLENEDIOXYPHENYL)-5-(2-PYRIDYL)-1H-IMIDAZOL-2-YL]-BENZAMIDE

4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE

InSolution? TGF-β RI Kinase Inhibitor VI, SB431542

TGF-β RI Kinase Inhibitor VI, SB431542

SB 431542 HYDRATE

Benzamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-

4-(5-benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1h-imidazol-2-yl)-benzamide hydrate

4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate

SB 431542 hydrate,4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate

4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate

4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imid

TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem

InSolution TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem

CS-89

4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide

4-[4-(2H-1,3-benzodioxol-5-yl)-5-(pyridin-2-yl)-1H-iMidazol-2-yl]benzaMide

4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide

SB 431542, 98%, a potent and selective inhibitor of ALK5

SB 431542USP/EP/BP

4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide

TGF-β RI Kinase Inhibitor VI SB431542 SB-431542

Transforming growth factor beta receptors,inhibit,TGF-β Receptor,SB-431542,SB431542,Inhibitor

301836-41-9

C22H16N4O3xH2O

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Cytokines, Growth Factors and Hormones

Cytokines and Growth Factors

Inhibitors

Anti-cancer&immunity

Smad

TGF-beta

Protein Kinase

Signalling