Gimeracil

Product Name: Gimeracil
CAS No.: 103766-25-2
Chemical Name: Gimeracil
Synonyms: CDHP;CDH3;CS-84;Gimost;gimestat;imeraciL;GIMERACIL;Gimeradll;Cadherin-3;P-cadherin
CBNumber: CB5362004
Molecular Formula: C5H4ClNO2
Formula Weight: 145.54
MOL File: 103766-25-2.mol

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Gimeracil Property

Melting point:: 274 °C
Boiling point:: 255.1±40.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 5 mg/ml).
pka: 4.50±1.00(Predicted)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey: ZPLQIPFOCGIIHV-UHFFFAOYSA-N
CAS DataBase Reference: 103766-25-2(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2075
Product name: Gimeracil
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $64.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2075
Product name: Gimeracil
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $159
Updated: 2024/03/01

TCI Chemical

Product number: C2243
Product name: Gimeracil
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $89
Updated: 2024/03/01

TCI Chemical

Product number: C2243
Product name: Gimeracil
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $295
Updated: 2024/03/01

Cayman Chemical

Product number: 16525
Product name: Gimeracil
Purity: ≥98%
Packaging: 100mg
Price: $68
Updated: 2024/03/01

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Gimeracil Chemical Properties,Usage,Production

Description

Gimeracil (103766-25-2) is a dihydropyrimidine dehydrogenase (DPD) inhibitor.? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Gimeracil is used along with 5-FU or Tegafur to prolong circulating concentrations of the drugs.1,2? Gimeracil has also been shown to act as a radiosensitizer via inhibition of homologous recombination in the repair of DNA double strand breaks.3

Chemical Properties

Off-White Solid

Uses

Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.

Uses

Gimeracil is an antitumor agent. Gimeracil is a potent inhibitor of dihydropyrimidine dehydrogenase (DPD).

Uses

Antitumor agent. A potent inhibitor of dihydropyrimidine dehydrogenase (DPD)

Definition

ChEBI: Gimeracil is an organic molecular entity.

References

1) Diasio (1999)?Clinical implications of dihydropyrimidine dehydrogenase inhibition; Oncology(Williston Park),?13?17 2) Kobayakawa and Kojima (2011),?Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies; Onco. Targets Ther.,?4?193 3) Sakata?et al.?(2011),?Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination; Cancer Sci.,?102?1712

Gimeracil Preparation Products And Raw materials

Raw materials

Preparation Products

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Gimeracil Suppliers

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View Lastest Price from Gimeracil manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Gimeracil 103766-25-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Henan Bao Enluo International TradeCo.，LTD

Product: Gimeracil 103766-25-2
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-08-02

Hebei Mojin Biotechnology Co., Ltd

Product: Gimeracil 103766-25-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20tons
Release date: 2023-09-01

103766-25-2, GimeracilRelated Search:

2,4-Dihydroxypyridine 2-Chloro-5-chloromethylpyridine Clopidol 5-CHLORO-1,2-DIHYDRO-4-METHOXY-2-OXO-3-PYRIDINECARBONITRILE 5-Chloropyridine-2,3-diol 2,4-Dihydroxypyridine Gimeracil-13C3 Gimeracil AURORA KA-4855 AURORA KA-6096 AURORA KA-3471 AURORA KA-2491 AURORA KA-8145 AURORA KA-3473 AURORA KA-6035 AURORA KA-4741 AURORA KA-3807 AURORA KA-4737

GIMERACIL

gimestat

5-Chloro-2,4-dihydroxypyridine

5-Chloro-4-hydroxy-2(1H)-pyridinone

5-Chloro-4-hydroxy-2-pyridone

2(1H)-Pyridinone,5-chloro-4-hydroxy-(9CI)

5-chloropyridine-2,4-diol

2(1H)-Pyridinone, 5-chloro-4-hydroxy-

Gimeracil,(CDHP)

CDHP

5-Chloro-2,4-pyridinediol

5-Chloro-4-hydroxy-2(1H)-pyridone

CS-84

（CDHP）Gimeracil

5-Chloro-4-hydroxy-2(1H)-pyridinone,5-chloro-2,4-pyridinediol,cdhp compound

5-Chloro-4-hydroxy pyridine-2(1H)-one (GIMERACIL)

5-Chloro-2,4-dihydroxypyridine 5-Chloro-2,4-pyridinediol 5-Chloro-4-hydroxy-2(1H)-pyridinone

Gimeracil Gimestat

Anti-CDH3, N-Terminal antibody produced in rabbit

Cadherin-3

CDH3

P-cadherin

Placental cadherin

Gimeracil Imp.(4-ME-CDHP)

Gimeracil, >=99%

Gimeracil &gt

imeraciL

5-chloro-4-hydroxy-1,2-dihydropyridin-2-one

Recombinant Human Cadherin-3/CDH3 Protein, His Tag

Recombinant Mouse P-Cadherin/Cdh3 Protein, Fc Tag

Gimeracil ISO 9001：2015 REACH

Gimost

Gimeradll

103766-25-2

Antitumors for Research and Experimental Use

PYRIDINE

Anticancer

oncology

Biochemistry

Chloropyridines

Halopyridines

Intermediates & Fine Chemicals

Pharmaceuticals

103766-25-2