4-Bromo-2-methoxypyridine
- Product Name
- 4-Bromo-2-methoxypyridine
- CAS No.
- 100367-39-3
- Chemical Name
- 4-Bromo-2-methoxypyridine
- Synonyms
- 4-BROMO-2-METHOXYPYRIDINE;2-Methoxy-4-broMoquinoline;Pyridine,4-bromo-2-methoxy-;4-Bromo-2-Methoxypyridine(WX637041);4-Bromo-2-methoxypyridine ISO 9001：2015 REACH
- CBNumber
- CB5371404
- Molecular Formula
- C6H6BrNO
- Formula Weight
- 188.02
- MOL File
- 100367-39-3.mol
4-Bromo-2-methoxypyridine Property
- Melting point:
- 25-26℃
- Boiling point:
- 87℃/15mm
- Density
- 1.530±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.76±0.10(Predicted)
- form
- Low Melting Solid
- color
- Off-white to pale yellow
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C6H6BrNO/c1-9-6-4-5(7)2-3-8-6/h2-4H,1H3
- InChIKey
- YFTGMMXMLPTTAY-UHFFFAOYSA-N
- SMILES
- C1(OC)=NC=CC(Br)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B696885
- Product name
- 4-Bromo-2-methoxypyridine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B696885
- Product name
- 4-Bromo-2-methoxypyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR11605
- Product name
- 4-Bromo-2-methoxypyridine
- Packaging
- 1g
- Price
- $17
- Updated
- 2021/12/16
- Product number
- 4H07-9-Y0
- Product name
- 4-Bromo-2-methoxypyridine
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- CAPOB12345
- Product name
- 4-Bromo-2-methoxypyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $23
- Updated
- 2021/12/16
4-Bromo-2-methoxypyridine Chemical Properties,Usage,Production
Uses
4-Bromo-2-methoxypyridine used in the synhesis of Imidazo [1, 2-a] pyrimidines. Suzuki coupling between 4-methoxyphenylboronic acid and 4-bromo-2-methoxypyridine affords 1, 5-disubstituted pyridones. Starting material used in a synthesis of crown-ester-bipyridines and viologens via sodium or nickel reductive coupling, side chain oxidation and esterification.
Synthesis
128071-98-7
124-41-4
100367-39-3
A non-homogeneous reaction mixture formed by 4-bromo-2-fluoropyridine (2.64 mL, 25.6 mmol) and sodium methanolate (8.29 g, 153 mmol) in methanol (36.5 mL) was placed in a pressure tube and reacted for 5 hours at 155°C. Upon completion of the reaction, the mixture was cooled to room temperature, filtered to remove the solid insoluble material and the solids were washed with ethyl acetate. The filtrate was concentrated to give a light yellow oil containing a small amount of white solid. The yellow oily material was decanted, diluted with water and the aqueous phase was extracted with ethyl acetate (2×). The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated to afford the target product 4-bromo-2-methoxypyridine (4.43 g, 21.20 mmol, 83% yield) as a yellow oil.LC-MS analysis: the calculated value of C6H6BrNO was 188.02, and the measured values of [M + H]+ were 187.9, 189.9. 1H NMR was used as the analyte. 189.9. 1H NMR (400 MHz, CDCl3) δ 7.98 (d, J = 5.5 Hz, 1H), 7.02 (dd, J = 5.5, 1.5 Hz, 1H), 6.94 (d, J = 1.8 Hz, 1H), 3.92 (s, 3H).
References
[1] Patent: WO2015/171722, 2015, A1. Location in patent: Page/Page column 67
4-Bromo-2-methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-2-methoxypyridine manufacturers
- Product
- 4-Bromo-2-methoxypyridine 100367-39-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
- Product
- 4-Bromo-2-methoxypyridine 100367-39-3
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 4-Bromo-2-methoxypyridine 100367-39-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25