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ENALAPRILAT DIHYDRATE

Product Name
ENALAPRILAT DIHYDRATE
CAS No.
84680-54-6
Chemical Name
ENALAPRILAT DIHYDRATE
Synonyms
MK-422;ENALAPRILATE;as dihydrate;ENALAPRILAT USP;MK-422 Dihydrate;Enalaprilate USP25;Vasotec IV Dihydrate;Inapulla (dihydrate);Enalaprilat (300 mg);ENALAPRILAT DIHYDRATE
CBNumber
CB5373019
Molecular Formula
C18H26N2O6
Formula Weight
366.41
MOL File
84680-54-6.mol
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ENALAPRILAT DIHYDRATE Property

Melting point:
151-159°C
alpha 
[α]D25 -53.0～-56.0゜ (c=1, CH3OH) (Calculated on dehydrous basis)
storage temp. 
2-8°C
solubility 
H2O: soluble14mg/mL at 60°C (warming for 5 minutes)
form 
Solid
color 
White to Off-White
Water Solubility 
H2O: 14mg/mL at60°C (warming for 5 minutes)
DMSO: 64mg/mL
InChIKey
MFNXXPRUKGSARH-MTPBSTKNNA-N
SMILES
C(N1CCC[C@H]1C(=O)O)(=O)[C@H](C)N[C@H](C(=O)O)CCC1C=CC=CC=1.O |&1:5,10,13,r|
CAS DataBase Reference
84680-54-6(CAS DataBase Reference)
EPA Substance Registry System
L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-, hydrate (1:2) (84680-54-6)
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Safety

WGK Germany 
3
RTECS 
TW3590600
HS Code 
2933995300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000615
Product name
Enalaprilat dihydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
100 mg
Price
$156
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR3440
Product name
Enalaprilat
Purity
certified reference material, pharmaceutical secondary standard
Packaging
500MG
Price
$515
Updated
2025/07/31
Sigma-Aldrich
Product number
E9658
Product name
Enalaprilat dihydrate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$138
Updated
2025/07/31
Sigma-Aldrich
Product number
BP742
Product name
Enalaprilat
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
20MG
Price
$245
Updated
2025/07/31
Sigma-Aldrich
Product number
1235274
Product name
Enalaprilat
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
300mg
Price
$501
Updated
2025/07/31
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ENALAPRILAT DIHYDRATE Chemical Properties,Usage,Production

Description

Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Enalaprilat is the active metabolite of enalapril , an ACE inhibitor with roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC50 value of 5.8 nM in vitro.

Chemical Properties

White Solid

Uses

anthelmintic

Uses

Active metabolite of Enalapril. A nonsulfhydryl dipeptide angiotensin converting enzyme (ACE) inhibitor. Enalapril EP Impurity C (Dihydrate).

Definition

ChEBI: The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients wi h nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.

Biochem/physiol Actions

Enalapril, the ethyl ester of?enalaprilat exhibits slight pharmacological activity until it is hydrolyzed in the liver to?enalaprilat. Enalaprilat, a IV form of an angiotensin-converting-enzyme inhibitor (ACE) prevents the transformation of angiotensin I to angiotensin II, a potent vasoconstrictor.

References

[1] PIERRE REDELINGHUYS  EDWARD D S  ALOYSIUS T NCHINDA. Development of Domain-Selective Angiotensin I-Converting Enzyme Inhibitors[J]. Annals of the New York Academy of Sciences, 2006, 1056 1: 160-175. DOI: 10.1196/annals.1352.035
[2] JAMES J. MENCEL. Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives[J]. Journal of Medicinal Chemistry, 1990, 33 6: 1606-1615. DOI: 10.1021/jm00168a013

ENALAPRILAT DIHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ENALAPRILAT DIHYDRATE Suppliers

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View Lastest Price from ENALAPRILAT DIHYDRATE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Enalaprilat Dihydrate 84680-54-6
Price
US $0.00/g/Bag
Min. Order
1g
Purity
98%-101%
Supply Ability
500G
Release date
2021-07-19
Henan Fengda Chemical Co., Ltd
Product
ENALAPRILAT DIHYDRATE 84680-54-6
Price
US $32.00-1.30/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-15
Baoji Guokang Healthchem co.,ltd
Product
ENALAPRILAT DIHYDRATE 84680-54-6
Price
US $793.70/g
Min. Order
10g
Purity
99%
Supply Ability
400G
Release date
2021-06-08

84680-54-6, ENALAPRILAT DIHYDRATERelated Search:

Enalaprilat Triphosgene Ethyl trans-3-Benzoylacrylate Enalapril EP IMpurity A (SSR) L-Proline (R,S,S)-Enalapril L-Alanine Enalapril diketopiperazine (αS)-Cyclohexanebutanoic Acid α-[[(1S)-1-Carboxyethyl]aMino] cyclohexanebutanoic Acid α-Ethyl Ester Ethyl 3-benzoylacrylate Phenylsilane Dimethylimidazole Phenyltrichlorosilane MOEXIPRIL HYDROCHLORIDE Fosinopril sodium CILAZAPRIL Belinostat (PXD101) CHLOROPHENYLSILANE

  • (S)-1-[N-[1-(CARBOXY)-3-PHENYLPROPYL]-L-ALANYL]-L-PROLINE, DIHYDRATE
  • MK-422
  • ENALAPRILAT DIHYDRATE
  • ENALAPRILATE
  • Enalaprilate USP25
  • ENALAPRILAT USP
  • Enalaprilat (300 mg)
  • Enalaprilic Acid Dihydrate
  • MK-422 Dihydrate
  • Vasotec IV Dihydrate
  • Enalapril Maleate IMpurity–C(EP)
  • Enalapril EP IMpurity C
  • L-Proline,1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-, dihydrate, (S)- (9CI)
  • N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline, hydrate (1:2)
  • Enalaprilat dihydrate, >=99%
  • as dihydrate
  • Enalaprilat for system suitability CRS
  • Enalaprilat dihydrate CRS
  • ENALAPRILAT DIHYDRATE USP/EP/BP
  • Enalaprilat (1235274)
  • (S)-1-((S)-2-(((S)-1-Carboxy-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic acid dihydrate
  • Enalapril EP Impurity C（Hydrate）
  • Enalaprilat, Angiotensin II converting enzyme inhibitor
  • Enalaprilat Dihydrate, 10 mM in DMSO
  • Inapulla (dihydrate)
  • 2,4-dichlorophenyl-2-(-1H-imidazole)ethanol
  • 84680-54-6
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Inhibitors