ChemicalBook > CAS DataBase List > ENALAPRILAT DIHYDRATE

ENALAPRILAT DIHYDRATE

Product Name
ENALAPRILAT DIHYDRATE
CAS No.
84680-54-6
Chemical Name
ENALAPRILAT DIHYDRATE
Synonyms
MK-422;ENALAPRILATE;as dihydrate;ENALAPRILAT USP;MK-422 Dihydrate;Enalaprilate USP25;Vasotec IV Dihydrate;Enalaprilat (300 mg);ENALAPRILAT DIHYDRATE;Enalaprilat (1235274)
CBNumber
CB5373019
Molecular Formula
C18H26N2O6
Formula Weight
366.41
MOL File
84680-54-6.mol
More
Less

ENALAPRILAT DIHYDRATE Property

Melting point:
151-159°C
alpha 
[α]D25 -53.0～-56.0゜ (c=1, CH3OH) (Calculated on dehydrous basis)
storage temp. 
2-8°C
solubility 
H2O: soluble14mg/mL at 60°C (warming for 5 minutes)
form 
Solid
color 
White to Off-White
Water Solubility 
H2O: 14mg/mL at60°C (warming for 5 minutes)
DMSO: 64mg/mL
CAS DataBase Reference
84680-54-6(CAS DataBase Reference)
EPA Substance Registry System
L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-, hydrate (1:2) (84680-54-6)
More
Less

Safety

WGK Germany 
3
RTECS 
TW3590600
HS Code 
2933995300
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E9658
Product name
Enalaprilat dihydrate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$134
Updated
2024/03/01
Sigma-Aldrich
Product number
1235274
Product name
Enalaprilat
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
300mg
Price
$519
Updated
2024/03/01
Sigma-Aldrich
Product number
BP742
Product name
Enalaprilat
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
20MG
Price
$227
Updated
2023/06/20
TCI Chemical
Product number
E1302
Product name
Enalaprilat Dihydrate
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$122
Updated
2024/03/01
TCI Chemical
Product number
E1302
Product name
Enalaprilat Dihydrate
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$363
Updated
2022/04/27
More
Less

ENALAPRILAT DIHYDRATE Chemical Properties,Usage,Production

Description

Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Enalaprilat is the active metabolite of enalapril , an ACE inhibitor with roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC50 value of 5.8 nM in vitro.

Chemical Properties

White Solid

Uses

anthelmintic

Uses

Active metabolite of Enalapril. A nonsulfhydryl dipeptide angiotensin converting enzyme (ACE) inhibitor. Enalapril EP Impurity C (Dihydrate).

Definition

ChEBI: The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients wi h nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.

Biochem/physiol Actions

Enalapril, the ethyl ester of?enalaprilat exhibits slight pharmacological activity until it is hydrolyzed in the liver to?enalaprilat. Enalaprilat, a IV form of an angiotensin-converting-enzyme inhibitor (ACE) prevents the transformation of angiotensin I to angiotensin II, a potent vasoconstrictor.

ENALAPRILAT DIHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

ENALAPRILAT DIHYDRATE Suppliers

Americas 1 Canada 2 China 134 China Hong Kong 1 Europe 1 France 1 Germany 1 India 9 Japan 2 United Kingdom 5 United States 27 Global 184
Wuhan Dingxintong Pharmaceutical Co. , Ltd.
Tel
027-52344656 15871722230
Fax
2796190295
Email
15871722230@163.com
Country
China
ProdList
4832
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8161
Advantage
52
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4728
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 1316706386
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1955
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7787
Advantage
56
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9650
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4943
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11788
Advantage
59
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9959
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
999
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Lancrix Chemicals
Tel
86-21-50817262
Fax
86-21-57712035
Email
sales@lancrix.com
Country
China
ProdList
1502
Advantage
55
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29763
Advantage
68
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1919
Advantage
55
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1927
Advantage
55
Wellman Pharmaceutical Group Limited
Tel
027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
3919
Advantage
58
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9462
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15084
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 18016230971
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
24987
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-63315541 13323832564
Fax
QQ:3001332135
Email
3001332135@qq.com
Country
China
ProdList
9998
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
TCI Chemicals
Tel
021-67121386, 800-988-0390
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
5391
Advantage
58
Aishilun biotechnology (Shanghai) co., LTD
Tel
021-50676523 18019098996
Email
info@acelybio.com
Country
China
ProdList
3960
Advantage
58
CR Corporation Limited
Tel
+8613062833949
Email
fred.wen@crcorporation.cn
Country
China
ProdList
8647
Advantage
58
Finetech Industry Limited
Tel
+86-27-87465837 +8618971612321
Fax
86 27 87772287
Email
info@finetechnology-ind.com
Country
China
ProdList
9641
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Guangzhou TongYi biochemistry technology Co.,LTD
Tel
+8613073028829
Email
mack@tongyon.com
Country
China
ProdList
2994
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19908
Advantage
58
Wuhan Fortuna Chemical Co., Ltd
Tel
+86-027-59207850
Fax
86-27-59524646
Email
info@fortunachem.com
Country
China
ProdList
5965
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52849
Advantage
58
More
Less

View Lastest Price from ENALAPRILAT DIHYDRATE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Enalaprilat Dihydrate 84680-54-6
Price
US $0.00/g/Bag
Min. Order
1g
Purity
98%-101%
Supply Ability
500G
Release date
2021-07-19
Henan Fengda Chemical Co., Ltd
Product
ENALAPRILAT DIHYDRATE 84680-54-6
Price
US $32.00-1.30/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-15
Baoji Guokang Healthchem co.,ltd
Product
ENALAPRILAT DIHYDRATE 84680-54-6
Price
US $793.70/g
Min. Order
10g
Purity
99%
Supply Ability
400G
Release date
2021-06-08

84680-54-6, ENALAPRILAT DIHYDRATERelated Search:

Enalaprilat Triphosgene Ethyl trans-3-Benzoylacrylate Enalapril EP IMpurity A (SSR) L-Proline (R,S,S)-Enalapril L-Alanine Enalapril diketopiperazine (αS)-Cyclohexanebutanoic Acid α-[[(1S)-1-Carboxyethyl]aMino] cyclohexanebutanoic Acid α-Ethyl Ester Ethyl 3-benzoylacrylate Phenylsilane CHLOROPHENYLSILANE 97 Dimethylimidazole Phenyltrichlorosilane MOEXIPRIL HYDROCHLORIDE Fosinopril sodium CILAZAPRIL Belinostat (PXD101)

  • (S)-1-[N-[1-(CARBOXY)-3-PHENYLPROPYL]-L-ALANYL]-L-PROLINE, DIHYDRATE
  • MK-422
  • ENALAPRILAT DIHYDRATE
  • ENALAPRILATE
  • Enalaprilate USP25
  • ENALAPRILAT USP
  • Enalaprilat (300 mg)
  • Enalaprilic Acid Dihydrate
  • MK-422 Dihydrate
  • Vasotec IV Dihydrate
  • Enalapril Maleate IMpurity–C(EP)
  • Enalapril EP IMpurity C
  • L-Proline,1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-, dihydrate, (S)- (9CI)
  • N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline, hydrate (1:2)
  • Enalaprilat dihydrate, >=99%
  • as dihydrate
  • Enalaprilat for system suitability CRS
  • Enalaprilat dihydrate CRS
  • ENALAPRILAT DIHYDRATE USP/EP/BP
  • Enalaprilat (1235274)
  • (S)-1-((S)-2-(((S)-1-Carboxy-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic acid dihydrate
  • Enalapril EP Impurity C（Hydrate）
  • Enalaprilat, Angiotensin II converting enzyme inhibitor
  • Enalaprilat Dihydrate, 10 mM in DMSO
  • 84680-54-6
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Inhibitors