2,6-Difluorobenzamide

Product Name: 2,6-Difluorobenzamide
CAS No.: 18063-03-1
Chemical Name: 2,6-Difluorobenzamide
Synonyms: 2,6-difluorobenzoic acid amide;uorobenzamide;2,6-Difluorbenzamid;2,6-DIFLUOROBENZAMIDE;2,6-difluoro-benzamid;2，6-difluorobenzaminde;2,6-Difluorobenzoamide;2,6-Difluorobenzoylamide;2,6-Difluorobenzamide97%;2,6-Difluorobenzamide>
CBNumber: CB5376515
Molecular Formula: C7H5F2NO
Formula Weight: 157.12
MOL File: 18063-03-1.mol

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2,6-Difluorobenzamide Property

Melting point:: 145-148 °C (lit.)
Boiling point:: 51-52C/15Tor
Density: 1,199g/cm
refractive index: 1,508
storage temp.: Sealed in dry,Room Temperature
solubility: ethanol: soluble5%, clear to turbid, colorless to light yellow
form: Solid
pka: 14.54±0.50(Predicted)
color: Off-White
BRN: 2047480
InChIKey: AVRQBXVUUXHRMY-UHFFFAOYSA-N
LogP: 0.011-0.25 at 25℃
CAS DataBase Reference: 18063-03-1(CAS DataBase Reference)
NIST Chemistry Reference: Benzamide, 2,6-difluoro-(18063-03-1)
EPA Substance Registry System: Benzamide, 2,6-difluoro- (18063-03-1)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20
Safety Statements: 26-37/39-36/37
WGK Germany: 1
RTECS: CV4355050
HazardClass: IRRITANT
HS Code: 29242990
Toxicity: rat,LC50,inhalation,> 2100mg/m3/4H (2100mg/m3),National Technical Information Service. Vol. OTS0543293,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 282278
Product name: 2,6-Difluorobenzamide
Purity: 97%
Packaging: 10g
Price: $19.45
Updated: 2025/07/31

Sigma-Aldrich

Product number: 282278
Product name: 2,6-Difluorobenzamide
Purity: 97%
Packaging: 50g
Price: $106
Updated: 2025/07/31

TCI Chemical

Product number: D1907
Product name: 2,6-Difluorobenzamide
Purity: >97.0%(N)
Packaging: 25g
Price: $30
Updated: 2025/07/31

TRC

Product number: D451843
Product name: 2,6-Difluorobenzamide
Packaging: 1g
Price: $45
Updated: 2021/12/16

TRC

Product number: D451843
Product name: 2,6-Difluorobenzamide
Packaging: 10g
Price: $70
Updated: 2021/12/16

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2,6-Difluorobenzamide Chemical Properties,Usage,Production

Description

2,6-Difluorobenzamide is a major metabolite of pesticide diflubenzuron and has been quantitated by HPLC/diode-array method.

Description

2,6-Difluorobenzamide is a white powdery crystal, insoluble in water. It can be obtained by hydrolysis of 2,6-difluorobenzonitrile. 2,6-Difluorobenzamide is an important intermediate in the synthesis process of benzoylurea insecticides, which is used to synthesize the next intermediate 2,6-difluorobenzoyl isocyanate, and finally obtain flubolurea, pyruron, fluridin, lice mite urea and other pesticide varieties. It can also be directly used to synthesize pyruron and flubolea. 2,6-Difluorobenzamide can inhibit the bacterial cell division protein FtsZ[1].

Chemical Properties

white to yellowish powder

Uses

2,6-Difluorobenzamide (CAS# 18063-03-1) is a useful building block used in the synthesis of (E)-3-methyleneisoindolin-1-ones via oxidative annulation acrylates. It is also used in the synthesis of pesticide intermediates, which can be used to produce various insecticides such as fluazuron, chlorpyrifos, and pyrethroids.

Preparation

2,6-Difluorobenzamide is obtained by hydrolysis of 2,6-difluorobenzonitrile.

Synthesis

1897-52-5

18063-03-1

General procedure for the synthesis of 2,6-difluorobenzamide from 2,6-difluorobenzonitrile: (1) 100 g (0.72 mol) of 2,6-difluorobenzonitrile was added slowly and dropwise to a mixed solution of 240 g of concentrated sulfuric acid and 24 ml of water at room temperature. The reaction mixture was stirred at 80°C to 85°C for 12 hours. After completion of the reaction, the mixture was slowly poured into 1.2 kg of ice water and stirred continuously for 30 minutes, followed by filtration. The resulting crystals were washed to neutrality with distilled water and finally dried under vacuum at 85°C. The yield was 91.0 g (80.6% yield) with a melting point of 140°C to 141.5°C.

Toxics Screening Level

The Initial Threshold Screening Level (ITSL) for 2,6-Difluorobenzamide is 11 μg/m3 based on an annual averaging time.

References

[1] Straniero V, et al. 2,6-Difluorobenzamide inhibitors of the bacterial cell division protein FtsZ: design, synthesis and Structure Activity Relationship study. ChemMedChem, 2017; 12: 1303-1318.

2,6-Difluorobenzamide Preparation Products And Raw materials

Raw materials

Potassium fluoride 2,6-Difluorobenzonitrile

Preparation Products

Flufenoxuron Hexaflumuron 2,6-Difluoroaniline 2,6-Difluorobenzoyl isocyanate Chlorfluazuron Diflubenzuron Teflubenzuron

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View Lastest Price from 2,6-Difluorobenzamide manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,6-Difluorobenzamide 18063-03-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-06-24

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2,6-Difluorobenzamide 18063-03-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-29

Anhui Royal Chemical Co., Ltd.

Product: 2,6-Difluorobenzamide 18063-03-1
Price: US $1.00/KG
Min. Order: 200KG
Purity: 99%
Supply Ability: 20ton
Release date: 2018-08-08

18063-03-1, 2,6-DifluorobenzamideRelated Search:

2,6-Difluorobenzoic acid Chlorantraniliprole p-Aminobenzamide 2,6-Difluorobenzonitrile Benzamide Difluorochloromethane 2,3,6-TRIFLUOROBENZAMIDE 4-AMINO-2,3,5,6-TETRAFLUOROBENZAMIDE Diflubenzuron Chlorfluazuron 2,6-Difluorobenzoyl hydrazine Teflubenzuron N-PENTAFLUOROBENZOYLIMIDAZOLE 2,3,4,5,6-PENTAFLUOROBENZAMIDE 3,5-DIFLUOROBENZAMIDE 2-CHLORO-3,6-DIFLUOROBENZAMIDE 3-CHLORO-2,6-DIFLUOROBENZAMIDE 2,5-DIFLUOROBENZAMIDE

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18063-03-1

C7H5NOF2

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Carbonyl Compounds

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Amides

Carbonyl Compounds

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

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intermediate

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C7

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18063-03-1

OLED