Diethyl 1H-imidazole-4,5-dicarboxylate
- Product Name
- Diethyl 1H-imidazole-4,5-dicarboxylate
- CAS No.
- 1080-79-1
- Chemical Name
- Diethyl 1H-imidazole-4,5-dicarboxylate
- Synonyms
- e-4,5-dicarboxyL;Diethyl 4,5-Imidazoledicarboxylate;Diethyl imidazole-4,5-dicarboxylate;iethyl 1H-imidazole-4,5-dicarboxylate;DIETHYL 1H-IMIDAZOLE-4,5-DICARBOXYLATE;DIETHYL(IMIDAZOLE-1H)-4,5-DICARBOXYLATE;DIETHYL 4,5-IMIDAZOLE-1H-4,5-DICARBOXYLATE;4,5-diethyl 1H-imidazole-4,5-dicarboxylate;Diethyl 1H-imidazole-4,5-dicarboxylate 98%;imidazole 4,5-dicarboxylic acid diethyl ester
- CBNumber
- CB5410286
- Molecular Formula
- C9H12N2O4
- Formula Weight
- 212.2
- MOL File
- 1080-79-1.mol
Diethyl 1H-imidazole-4,5-dicarboxylate Property
- Melting point:
- 210-216
- Boiling point:
- 357.9±22.0 °C(Predicted)
- Density
- 1.249±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.70±0.10(Predicted)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933299090
N-Bromosuccinimide Price
- Product number
- D443698
- Product name
- Diethyl4,5-imidazole-1H-4,5-dicarboxylate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FD149731
- Product name
- Diethyl1H-imidazole-4,5-dicarboxylate
- Packaging
- 1g
- Price
- $78
- Updated
- 2021/12/16
- Product number
- V0760
- Product name
- Diethyl1H-imidazole-4,5-dicarboxylate
- Packaging
- 1g
- Price
- $43
- Updated
- 2021/12/16
- Product number
- J94731
- Product name
- Diethyl1H-imidazole-4,5-dicarboxylate
- Packaging
- 10g
- Price
- $128
- Updated
- 2021/12/16
- Product number
- FD149731
- Product name
- Diethyl1H-imidazole-4,5-dicarboxylate
- Packaging
- 2g
- Price
- $135
- Updated
- 2021/12/16
Diethyl 1H-imidazole-4,5-dicarboxylate Chemical Properties,Usage,Production
Synthesis
50-00-0
87-91-2
1080-79-1
Diethyl 1H-imidazole-4,5-dicarboxylate was synthesized as follows (Ref. Example 3): under non-shade conditions. Diethyl L-(+)-tartaric acid (2.0 g) was dissolved in ethyl acetate (34.2 ml), 1,3-dibromo-5,5-dimethylglycolide (3.3 g) was added, and the reaction solution was stirred for 3 hours at room temperature. Subsequently, acetic acid (17 ml) was added to the reaction solution, followed by the slow addition of 36% aqueous formaldehyde solution (3.45 ml) under cooling in an ice bath, keeping the internal temperature at 10°C or lower. Ammonium acetate (17.2 g) was added under the same temperature conditions. The reaction solution was stirred at room temperature for 30 minutes, then warmed up to 50°C and continued stirring for 3 hours. After completion of the reaction, 5N sodium hydroxide solution was added to the reaction solution and the aqueous layer was extracted with ethyl acetate. The organic layers were combined and dried with anhydrous magnesium sulfate. The ethyl acetate solution was quantitatively analyzed by HPLC to obtain the title compound 1H-imidazole-4,5-dicarboxylic acid diethyl ester (1.24 g, yield: 60%).The HPLC analysis conditions were the same as in Example 5. The results with reference to Example 3 and Example 5 show that the preparation method of the present invention is superior to the known method X for the preparation of diethyl 1H-imidazole-4,5-dicarboxylate from diethyl L-(+)-tartaric acid under non-shade conditions in terms of yield.
References
[1] Patent: EP2298763, 2011, A1. Location in patent: Page/Page column 31
Diethyl 1H-imidazole-4,5-dicarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Diethyl 1H-imidazole-4,5-dicarboxylate manufacturers
- Product
- Diethyl 1H-imidazole-4,5-dicarboxylate 1080-79-1
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10
- Release date
- 2024-07-14
- Product
- Diethyl 1H-imidazole-4,5-dicarboxylate 1080-79-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-03