Ropinirole hydrochloride
- Product Name
- Ropinirole hydrochloride
- CAS No.
- 91374-20-8
- Chemical Name
- Ropinirole hydrochloride
- Synonyms
- ROPINIROLE HCL;REQUIP;4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone Hydrochloride;Requi;SKF-101468A;Ropinirole HCl API;Ropinirole Hcl ,99%;Ropinirole hydrochlo;Ropinero hydrochloride;Ropinirol hydrochloride
- CBNumber
- CB5420618
- Molecular Formula
- C16H25ClN2O
- Formula Weight
- 296.84
- MOL File
- 91374-20-8.mol
Ropinirole hydrochloride Property
- Melting point:
- 241-243°C
- storage temp.
- 2-8°C
- solubility
- H2O: >10mg/mL
- form
- powder
- color
- light yellow
- InChI
- InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
- InChIKey
- XDXHAEQXIBQUEZ-UHFFFAOYSA-N
- SMILES
- C12CC(=O)NC=1C=CC=C2CCN(CCC)CCC.Cl
- CAS DataBase Reference
- 91374-20-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,N,Xi
- Risk Statements
- 22-50/53-36/38
- Safety Statements
- 36-60-61-37/39-26
- RIDADR
- UN 3077 9/PG 3
- WGK Germany
- 3
- RTECS
- NM3288250
- HS Code
- 2933790002
N-Bromosuccinimide Price
- Product number
- PHR1633
- Product name
- Ropinirole hydrochloride
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 200mg
- Price
- $237
- Updated
- 2024/03/01
- Product number
- 1605205
- Product name
- Ropinirole hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $1230
- Updated
- 2024/03/01
- Product number
- Y0001776
- Product name
- Ropinirole for peak identification 2
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0001776
- Price
- $147
- Updated
- 2023/06/20
- Product number
- Y0001775
- Product name
- Ropinirole for peak identification 1
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0001775
- Price
- $149
- Updated
- 2023/06/20
- Product number
- Y0002019
- Product name
- Ropinirole for peak identification 3
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- Y0002019
- Price
- $149
- Updated
- 2023/01/07
Ropinirole hydrochloride Chemical Properties,Usage,Production
Description
ReQuip was launched in the UK as a monotherapy or in combination with low-dose levodopa for the treatment of early-stage idiopathic Parkinson's disease. An eight step (24% overall yield) synthesis from isochroman provides access to ropinirole. It is a non-ergot postsynaptic dopamine D2 agonist with activity in the extrapyramidal system. It has weak or no significant activity at α2-adrenergic, 5-HT2 receptors and is inactive at 5-HT1, benzodiazepine, GABA, α1 and β adrenoreceptors. Thus it has essentially no CNS side effects, fewer dyskinesias and on-off fluctuations. In animals, it was able to reverse all motor deficits induced by MPTP. Tolerance is not developed and ropinirole has similar postsynaptic potency to apomorphine but with significantly less stereotyped behavior.
Description
Ropinirole is a potent dopamine D2 receptor agonist (Ki = 29 nM in a radioligand binding assay). It is selective for D2 over D1 dopamine receptors (Ki = >100,000 nM) as well as a panel of adrenergic, serotonin, benzodiazepine, and GABA receptors (IC50s = >9,000 nM). Ropinirole reduces spontaneous locomotor activity in mice at doses less than 50 mg/kg but increases it at a dose of 100 mg/kg. It also induces contralateral asymmetry in an open field test in 6-OHDA-lesioned mice. Ropinirole (0.01-1 mg/kg) reverses locomotor deficits and restores interest in novel stimuli in a marmoset model of Parkinson''s disease induced by MPTP. Formulations containing ropinirole have been used for the treatment of Parkinson''s disease motor dysfunction.
Chemical Properties
Off-White Solid
Originator
SmithKline Beecham (UK)
Uses
An antiparkinsonian agent. A selective dopamine D2-receptor agonist
Uses
antiparkinsonian;non-ergoline D2, D3, and D4 dopamine receptor agonist with highest affinity for D3
Definition
ChEBI: Ropinirole hydrochloride is a member of indoles.
brand name
Requip (GlaxoSmithKline).
General Description
Ropinirole hydrochloride,4-(2-(dipropylamino)ethyl)indolin-2-one hydrochloride(Requip), is a white to pale greenish yellow powder that isvery soluble in water. Ropinirole is rapidly absorbed afteroral administration with maximal plasma concentrationsgenerally reached after about 1.5 hours, and the eliminationhalf-life appears to be approximately 3 hours. Ropinirole isalso rapidly and extensively distributed from the vascularcompartment and shows low plasma protein binding that isindependent of its plasma concentration. This drug iscleared by metabolism in the liver, with only 10% being excretedunchanged. The main metabolite of ropinirole is theN-despropyl metabolite. The glucuronide of this metaboliteand the carboxylic acid metabolite, 4-carboxymethylindolin-2-one, account only for 10% of the administered dose.None of the metabolites is pharmacologically active, and theexcretion of ropinirole-derived products is mainly via theurine. The main CYP450 isozyme involved in the metabolismof ropinirole is CYP1A2. Inhibitors or inducers ofthis enzyme have been shown to alter the clearance ofropinirole.Ropinirole is believed to act as an agonist atpostsynaptic D2 receptors. Ropinirole is indicated for thetreatment of the signs and symptoms of idiopathic PD andmoderate to severe primary RLS.
Biological Activity
Selective D 2 -like receptor agonist (D 3 > D 2 > D 4 ). Causes biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice. Displays antiParkinsonian activity.
Biochem/physiol Actions
An agonist at the D2 and D3 dopamine receptor subtypes, binding with higher affinity to D3 than to D2 or D4. It has negligible effect on D1-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.
storage
Room temperature (desiccate)
Ropinirole hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ropinirole hydrochloride manufacturers
- Product
- Ropinirole hydrochloride 91374-20-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-09-05
- Product
- Ropinirole hydrochloride 91374-20-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-22
- Product
- Ropinirole hydrochloride 91374-20-8
- Price
- US $0.00/g/Bag
- Min. Order
- 1g
- Purity
- 99%min
- Supply Ability
- 1000g
- Release date
- 2021-11-17