ChemicalBook > CAS DataBase List > Ropinirole hydrochloride

Ropinirole hydrochloride

Product Name
Ropinirole hydrochloride
CAS No.
91374-20-8
Chemical Name
Ropinirole hydrochloride
Synonyms
ROPINIROLE HCL;REQUIP;4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone Hydrochloride;Requi;SKF-101468A;SKF-101468 HCl;Ropinirole HCl API;Ropinirole Hcl ,99%;Ropinirole hydrochlo;Ropinib hydrochloride
CBNumber
CB5420618
Molecular Formula
C16H25ClN2O
Formula Weight
296.84
MOL File
91374-20-8.mol
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Ropinirole hydrochloride Property

Melting point:
241-243°C
storage temp. 
2-8°C
solubility 
H2O: >10mg/mL
form 
powder
color 
light yellow
InChI
InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
InChIKey
XDXHAEQXIBQUEZ-UHFFFAOYSA-N
SMILES
C12CC(=O)NC=1C=CC=C2CCN(CCC)CCC.Cl
CAS DataBase Reference
91374-20-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,N,Xi
Risk Statements 
22-50/53-36/38
Safety Statements 
36-60-61-37/39-26
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
RTECS 
NM3288250
HS Code 
2933790002
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1633
Product name
Ropinirole hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
200mg
Price
$237
Updated
2024/03/01
Sigma-Aldrich
Product number
1605205
Product name
Ropinirole hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$1230
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001776
Product name
Ropinirole for peak identification 2
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0001776
Price
$147
Updated
2023/06/20
Sigma-Aldrich
Product number
Y0001775
Product name
Ropinirole for peak identification 1
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0001775
Price
$149
Updated
2023/06/20
Sigma-Aldrich
Product number
Y0002019
Product name
Ropinirole for peak identification 3
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0002019
Price
$149
Updated
2023/01/07
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Ropinirole hydrochloride Chemical Properties,Usage,Production

Description

ReQuip was launched in the UK as a monotherapy or in combination with low-dose levodopa for the treatment of early-stage idiopathic Parkinson's disease. An eight step (24% overall yield) synthesis from isochroman provides access to ropinirole. It is a non-ergot postsynaptic dopamine D2 agonist with activity in the extrapyramidal system. It has weak or no significant activity at α2-adrenergic, 5-HT2 receptors and is inactive at 5-HT1, benzodiazepine, GABA, α1 and β adrenoreceptors. Thus it has essentially no CNS side effects, fewer dyskinesias and on-off fluctuations. In animals, it was able to reverse all motor deficits induced by MPTP. Tolerance is not developed and ropinirole has similar postsynaptic potency to apomorphine but with significantly less stereotyped behavior.

Description

Ropinirole is a potent dopamine D2 receptor agonist (Ki = 29 nM in a radioligand binding assay). It is selective for D2 over D1 dopamine receptors (Ki = >100,000 nM) as well as a panel of adrenergic, serotonin, benzodiazepine, and GABA receptors (IC50s = >9,000 nM). Ropinirole reduces spontaneous locomotor activity in mice at doses less than 50 mg/kg but increases it at a dose of 100 mg/kg. It also induces contralateral asymmetry in an open field test in 6-OHDA-lesioned mice. Ropinirole (0.01-1 mg/kg) reverses locomotor deficits and restores interest in novel stimuli in a marmoset model of Parkinson''s disease induced by MPTP. Formulations containing ropinirole have been used for the treatment of Parkinson''s disease motor dysfunction.

Chemical Properties

Off-White Solid

Originator

SmithKline Beecham (UK)

Uses

An antiparkinsonian agent. A selective dopamine D2-receptor agonist

Uses

antiparkinsonian;non-ergoline D2, D3, and D4 dopamine receptor agonist with highest affinity for D3

Definition

ChEBI: Ropinirole hydrochloride is a member of indoles.

brand name

Requip (GlaxoSmithKline).

General Description

Ropinirole hydrochloride,4-(2-(dipropylamino)ethyl)indolin-2-one hydrochloride(Requip), is a white to pale greenish yellow powder that isvery soluble in water. Ropinirole is rapidly absorbed afteroral administration with maximal plasma concentrationsgenerally reached after about 1.5 hours, and the eliminationhalf-life appears to be approximately 3 hours. Ropinirole isalso rapidly and extensively distributed from the vascularcompartment and shows low plasma protein binding that isindependent of its plasma concentration. This drug iscleared by metabolism in the liver, with only 10% being excretedunchanged. The main metabolite of ropinirole is theN-despropyl metabolite. The glucuronide of this metaboliteand the carboxylic acid metabolite, 4-carboxymethylindolin-2-one, account only for 10% of the administered dose.None of the metabolites is pharmacologically active, and theexcretion of ropinirole-derived products is mainly via theurine. The main CYP450 isozyme involved in the metabolismof ropinirole is CYP1A2. Inhibitors or inducers ofthis enzyme have been shown to alter the clearance ofropinirole.Ropinirole is believed to act as an agonist atpostsynaptic D2 receptors. Ropinirole is indicated for thetreatment of the signs and symptoms of idiopathic PD andmoderate to severe primary RLS.

Biological Activity

Selective D 2 -like receptor agonist (D 3 > D 2 > D 4 ). Causes biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice. Displays antiParkinsonian activity.

Biochem/physiol Actions

An agonist at the D2 and D3 dopamine receptor subtypes, binding with higher affinity to D3 than to D2 or D4. It has negligible effect on D1-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.

storage

Room temperature (desiccate)

Ropinirole hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Ropinirole hydrochloride Suppliers

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View Lastest Price from Ropinirole hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Ropinirole hydrochloride 91374-20-8
Price
US $0.00/g/Bag
Min. Order
1g
Purity
99%min
Supply Ability
1000g
Release date
2021-11-17
Shaanxi Haibo Biotechnology Co., Ltd
Product
Ropinirole hydrochloride 91374-20-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-09-05
Henan Fengda Chemical Co., Ltd
Product
Ropinirole hydrochloride 91374-20-8
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-22

91374-20-8, Ropinirole hydrochlorideRelated Search:

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  • Ropinirol hydrochloride
  • 4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone Hydrochloride
  • 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one Hydrochloride
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  • REQUIP
  • SKF-101468A
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  • ROPINIROLE HYDROCHLORIDE
  • SKF 101468 hydrochloride, 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride
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  • SKF 101468 hydrochloride
  • 4-(2-dipropylaminoethyl)-1,3-dihydroindol-2-one hydrochloride
  • Ropinirole hydrochlo
  • Ropinirole HCl API
  • 2H-Indol-2-one, 4-[2-(dipropylaMino)ethyl]-1,3-dihydro-, hydrochloride (1:1)
  • 4-(2-(DipropylaMino)ethyl)indolin-2-one hydrochloride
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  • Ropinirole hydrochloride###Ropinirole
  • 4(2DIPROPYLAMINOETHYL)1,3DHINDOLE2ONEHCL
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  • Ropinirole hydrochloride CRS
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  • Ropinirole for peak identification 1
  • Ropinirole for peak identification 2
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  • Ropinirole HydrochlorideQ: What is Ropinirole Hydrochloride Q: What is the CAS Number of Ropinirole Hydrochloride Q: What is the storage condition of Ropinirole Hydrochloride Q: What are the applications of Ropinirole Hydrochloride
  • TIANFU-CHEM Ropinirole hydrochloride
  • Ropinirole Hydrochloride (1605205)
  • Ropinero hydrochloride
  • Ropinib hydrochloride
  • Ropiniero hydrochloride
  • SKF-101468 HCl
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  • 91374-20-8
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  • C16H24N2OHCl
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  • Ropinirole
  • Medicine intermediate