Ropinirole hydrochloride

ChemicalBook > CAS DataBase List > Ropinirole hydrochloride

Ropinirole hydrochloride

Product Name: Ropinirole hydrochloride
CAS No.: 91374-20-8
Chemical Name: Ropinirole hydrochloride
Synonyms: ROPINIROLE HCL;REQUIP;4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone Hydrochloride;Requi;SKF-101468A;Ropinirole HCl API;Ropinirole Hcl ,99%;Ropinirole hydrochlo;Ropinib hydrochloride;Ropinero hydrochloride
CBNumber: CB5420618
Molecular Formula: C16H25ClN2O
Formula Weight: 296.84
MOL File: 91374-20-8.mol

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Ropinirole hydrochloride Property

Melting point:: 241-243°C
storage temp.: 2-8°C
solubility: H2O: >10mg/mL
form: powder
color: light yellow
InChI: InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
InChIKey: XDXHAEQXIBQUEZ-UHFFFAOYSA-N
SMILES: C12CC(=O)NC=1C=CC=C2CCN(CCC)CCC.Cl
CAS DataBase Reference: 91374-20-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,N,Xi
Risk Statements: 22-50/53-36/38
Safety Statements: 36-60-61-37/39-26
RIDADR: UN 3077 9/PG 3
WGK Germany: 3
RTECS: NM3288250
HS Code: 2933790002

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1633
Product name: Ropinirole hydrochloride
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 200mg
Price: $237
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1605205
Product name: Ropinirole hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $1230
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001776
Product name: Ropinirole for peak identification 2
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0001776
Price: $147
Updated: 2023/06/20

Sigma-Aldrich

Product number: Y0001775
Product name: Ropinirole for peak identification 1
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0001775
Price: $149
Updated: 2023/06/20

Sigma-Aldrich

Product number: Y0002019
Product name: Ropinirole for peak identification 3
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0002019
Price: $149
Updated: 2023/01/07

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Ropinirole hydrochloride Chemical Properties,Usage,Production

Description

ReQuip was launched in the UK as a monotherapy or in combination with low-dose levodopa for the treatment of early-stage idiopathic Parkinson's disease. An eight step (24% overall yield) synthesis from isochroman provides access to ropinirole. It is a non-ergot postsynaptic dopamine D₂ agonist with activity in the extrapyramidal system. It has weak or no significant activity at α₂-adrenergic, 5-HT₂ receptors and is inactive at 5-HT₁, benzodiazepine, GABA, α₁ and β adrenoreceptors. Thus it has essentially no CNS side effects, fewer dyskinesias and on-off fluctuations. In animals, it was able to reverse all motor deficits induced by MPTP. Tolerance is not developed and ropinirole has similar postsynaptic potency to apomorphine but with significantly less stereotyped behavior.

Description

Ropinirole is a potent dopamine D₂ receptor agonist (K_i = 29 nM in a radioligand binding assay). It is selective for D₂ over D₁ dopamine receptors (K_i = >100,000 nM) as well as a panel of adrenergic, serotonin, benzodiazepine, and GABA receptors (IC₅₀s = >9,000 nM). Ropinirole reduces spontaneous locomotor activity in mice at doses less than 50 mg/kg but increases it at a dose of 100 mg/kg. It also induces contralateral asymmetry in an open field test in 6-OHDA-lesioned mice. Ropinirole (0.01-1 mg/kg) reverses locomotor deficits and restores interest in novel stimuli in a marmoset model of Parkinson''s disease induced by MPTP. Formulations containing ropinirole have been used for the treatment of Parkinson''s disease motor dysfunction.

Chemical Properties

Off-White Solid

Originator

SmithKline Beecham (UK)

Uses

An antiparkinsonian agent. A selective dopamine D2-receptor agonist

Uses

antiparkinsonian;non-ergoline D2, D3, and D4 dopamine receptor agonist with highest affinity for D3

Definition

ChEBI: Ropinirole hydrochloride is a member of indoles.

brand name

Requip (GlaxoSmithKline).

General Description

Ropinirole hydrochloride,4-(2-(dipropylamino)ethyl)indolin-2-one hydrochloride(Requip), is a white to pale greenish yellow powder that isvery soluble in water. Ropinirole is rapidly absorbed afteroral administration with maximal plasma concentrationsgenerally reached after about 1.5 hours, and the eliminationhalf-life appears to be approximately 3 hours. Ropinirole isalso rapidly and extensively distributed from the vascularcompartment and shows low plasma protein binding that isindependent of its plasma concentration. This drug iscleared by metabolism in the liver, with only 10% being excretedunchanged. The main metabolite of ropinirole is theN-despropyl metabolite. The glucuronide of this metaboliteand the carboxylic acid metabolite, 4-carboxymethylindolin-2-one, account only for 10% of the administered dose.None of the metabolites is pharmacologically active, and theexcretion of ropinirole-derived products is mainly via theurine. The main CYP450 isozyme involved in the metabolismof ropinirole is CYP1A2. Inhibitors or inducers ofthis enzyme have been shown to alter the clearance ofropinirole.Ropinirole is believed to act as an agonist atpostsynaptic D₂ receptors. Ropinirole is indicated for thetreatment of the signs and symptoms of idiopathic PD andmoderate to severe primary RLS.

Biological Activity

Selective D 2 -like receptor agonist (D 3 > D 2 > D 4 ). Causes biphasic spontaneous locomotor activity and contralateral circling in 6-OHDA-lesioned mice. Displays antiParkinsonian activity.

Biochem/physiol Actions

An agonist at the D2 and D3 dopamine receptor subtypes, binding with higher affinity to D3 than to D2 or D4. It has negligible effect on D1-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.

storage

Room temperature (desiccate)

Ropinirole hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ropinirole hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ropinirole hydrochloride 91374-20-8
Price: US $0.00/g/Bag
Min. Order: 1g
Purity: 99%min
Supply Ability: 1000g
Release date: 2021-11-17

Shaanxi Haibo Biotechnology Co., Ltd

Product: Ropinirole hydrochloride 91374-20-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-09-05

Henan Fengda Chemical Co., Ltd

Product: Ropinirole hydrochloride 91374-20-8
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-22

91374-20-8, Ropinirole hydrochlorideRelated Search:

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Ropinirol hydrochloride

4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone Hydrochloride

4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one Hydrochloride

Requi

1,3-dihydro-4-(2-(dipropylamino)ethyl)-2h-indol-2-onemonohydrochloride

1,3-dihydro-4-(2-(dipropylamino)ethyl)-2h-indol-2-onmonohydrochloride

4-(2-(dipropylamino)ethyl)-2-indolinonemonohydrochloride

REQUIP

SKF-101468A

ROPINIROLE HCL

ROPINIROLE HYDROCHLORIDE

SKF 101468 hydrochloride, 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride

4-[2-(Dipropylamino)ethyl]-2-indolinone·hydrochloride

4-[2-(Dipropylamino)ethyl]indoline-2-one·hydrochloride

Ropinirole Hcl ,99%

SKF 101468 hydrochloride

4-(2-dipropylaminoethyl)-1,3-dihydroindol-2-one hydrochloride

Ropinirole hydrochlo

Ropinirole HCl API

2H-Indol-2-one, 4-[2-(dipropylaMino)ethyl]-1,3-dihydro-, hydrochloride (1:1)

4-(2-(DipropylaMino)ethyl)indolin-2-one hydrochloride

Ropinirole (as hydrochloride)

Ropinirole hydrochloride###Ropinirole

4(2DIPROPYLAMINOETHYL)1,3DHINDOLE2ONEHCL

Ropinirole for peak identification 1 CRS

Ropinirole hydrochloride CRS

Ropinirole for peak identification 2 CRS

Ropinirole for peak identification 1

Ropinirole for peak identification 2

Ropinirole hydrochloride USP/EP/BP

Ropinirole HydrochlorideQ: What is Ropinirole Hydrochloride Q: What is the CAS Number of Ropinirole Hydrochloride Q: What is the storage condition of Ropinirole Hydrochloride Q: What are the applications of Ropinirole Hydrochloride

TIANFU-CHEM Ropinirole hydrochloride

Ropinirole Hydrochloride (1605205)

Ropinero hydrochloride

Ropinib hydrochloride

Ropiniero hydrochloride

91374-20-8

1374-20-8

91347-20-8

C16H24N2OHCl

Inhibitors

Amine

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Ropinirole

Medicine intermediate