METHYL 3-METHYLAMINOCROTONATE

Product Name: METHYL 3-METHYLAMINOCROTONATE
CAS No.: 13412-12-9
Chemical Name: METHYL 3-METHYLAMINOCROTONATE
Synonyms: METHYL 3-METHYLAMINOCROTONATE;Methyl 3-methylaminocrotonate,97%;Methyl beta-(methylamino)crotonate;METHYL 3-(METHYLAMINO)BUT-2-ENOATE;Methyl 3-(methylamino)-2-butenoate;methyl (E)-3-(methylamino)but-2-enoate;3-Methylaminobut-2-enoic acid methyl ester;beta-N-methylaminocapronic acid methyl ester;2-Butenoic acid, 3-(MethylaMino)-, Methyl ester;(E)-3-(methylamino)-2-butenoic acid methyl ester
CBNumber: CB5439210
Molecular Formula: C6H11NO2
Formula Weight: 129.16
MOL File: 13412-12-9.mol

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METHYL 3-METHYLAMINOCROTONATE Property

Melting point:: 62-68 °C
Boiling point:: 187.5±23.0 °C(Predicted)
Density: 0.969±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 5.73±0.70(Predicted)
Appearance: White to off-white Solid
Water Solubility: Soluble in water at (54 g/L) (25°C), Calc.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
HS Code: 29224985

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CVT00049
Product name: Methyl 3-(methylamino)-2-butenoate
Packaging: 1g
Price: $286
Updated: 2025/07/31

TRC

Product number: M339780
Product name: Methyl3-Methylaminocrotonate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: X6686
Product name: Methyl3-methylaminocrotonate
Packaging: 1g
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 083726
Product name: Methyl 3-(methylamino)but-2-enoate
Purity: 97%
Packaging: 1g
Price: $66
Updated: 2021/12/16

AK Scientific

Product number: J97343
Product name: Methyl3-methylaminocrotonate
Packaging: 250mg
Price: $22
Updated: 2021/12/16

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METHYL 3-METHYLAMINOCROTONATE Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

It is employed as an intermediate in the synthesis of an analogue to amlodipine, bearing a short amino polyethylene glycol chain.

Synthesis

105-45-3

74-89-5

13412-12-9

1.2 g of silica gel was added to 11.6 g (100 mmol, 1 eq.) of methyl acetoacetate. To this was added 9.25 g (120 mmol, 1.2 eq.) of methylamine solution (40% aqueous solution) and the mixture was stirred overnight. The reaction mixture was extracted with dichloromethane (DCM), dried with anhydrous magnesium sulfate (MgSO?), filtered and the solvent was evaporated to give the yellow oily product methyl 3-(methylamino)but-2-enoate in 12.21 g, 95% yield.1H-NMR (CDCl?, δ/ppm): 8.47 (s, NH, 1H), 4.47 (s, CH, 1H). 3.61 (s, OCH?, 3H), 2.91 (d, NHCH?, J = 5.22 Hz, 3H), 1.92 (s, CH?, 3H).

References

[1] RSC Advances, 2015, vol. 5, # 49, p. 39193 - 39204
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 8, p. 1944 - 1947
[3] Patent: WO2013/25733, 2013, A1. Location in patent: Paragraph 0402
[4] Chemical and Pharmaceutical Bulletin, 1987, vol. 35, # 12, p. 4819 - 4828
[5] Bulletin de la Societe Chimique de France, 1923, vol. <4> 33, p. 1108

METHYL 3-METHYLAMINOCROTONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 3-METHYLAMINOCROTONATE Suppliers

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13412-12-9, METHYL 3-METHYLAMINOCROTONATERelated Search:

ETHYL (E)-3-(1-PYRROLIDINO)CROTONATE ETHYL 3-(4-FLUOROANILINO)CROTONATE D-(-)-A-4-HYDROXYPHENYLGLYCINE DANE SALT METHYL POTASSIUM DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE METHYL 3-METHYLAMINOCROTONATE Ethyl 3-(methylamino)-2-butenoate Nifedipine Ethyl 3-anilinobut-2-enoate Nitrendipine Nicardipine hydrochloride Crotonic acid trans-Methyl crotonate Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Crotonic acid 2,2-DIMETHYL-5-(2-TETRAHYDROPYRROLYLIDENE)-1,3-DIOXANE-4,6-DIONE 2,2-DIMETHYL-5-(2-HEXAHYDROAZEPINYLIDENE)-1,3-DIOXAN-4,6-DIONE 2-HYDROXY-6-METHYL-4-PHENYL-1,4-DIHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER ETHYL 2-AZEPAN-2-YLIDENACETATE

METHYL 3-(METHYLAMINO)BUT-2-ENOATE

METHYL 3-METHYLAMINOCROTONATE

Methyl 3-methylaminocrotonate,97%

Methyl beta-(methylamino)crotonate

2-Butenoic acid, 3-(MethylaMino)-, Methyl ester

3-Methylaminobut-2-enoic acid methyl ester

Methyl 3-(methylamino)-2-butenoate

beta-N-methylaminocapronic acid methyl ester

(E)-3-(methylamino)-2-butenoic acid methyl ester

methyl (E)-3-(methylamino)but-2-enoate

13412-12-9

CH3CNHCH3CHCO2CH3