METHYL 3-METHYLAMINOCROTONATE
- Product Name
- METHYL 3-METHYLAMINOCROTONATE
- CAS No.
- 13412-12-9
- Chemical Name
- METHYL 3-METHYLAMINOCROTONATE
- Synonyms
- METHYL 3-METHYLAMINOCROTONATE;Methyl 3-methylaminocrotonate,97%;Methyl beta-(methylamino)crotonate;METHYL 3-(METHYLAMINO)BUT-2-ENOATE;Methyl 3-(methylamino)-2-butenoate;methyl (E)-3-(methylamino)but-2-enoate;3-Methylaminobut-2-enoic acid methyl ester;beta-N-methylaminocapronic acid methyl ester;2-Butenoic acid, 3-(MethylaMino)-, Methyl ester;(E)-3-(methylamino)-2-butenoic acid methyl ester
- CBNumber
- CB5439210
- Molecular Formula
- C6H11NO2
- Formula Weight
- 129.16
- MOL File
- 13412-12-9.mol
METHYL 3-METHYLAMINOCROTONATE Property
- Melting point:
- 62-68 °C
- Boiling point:
- 187.5±23.0 °C(Predicted)
- Density
- 0.969±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 5.73±0.70(Predicted)
- Appearance
- White to off-white Solid
- Water Solubility
- Soluble in water at (54 g/L) (25°C), Calc.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CVT00049
- Product name
- Methyl 3-(methylamino)-2-butenoate
- Packaging
- 1g
- Price
- $286
- Updated
- 2025/07/31
- Product number
- M339780
- Product name
- Methyl3-Methylaminocrotonate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- X6686
- Product name
- Methyl3-methylaminocrotonate
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 083726
- Product name
- Methyl 3-(methylamino)but-2-enoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $66
- Updated
- 2021/12/16
- Product number
- J97343
- Product name
- Methyl3-methylaminocrotonate
- Packaging
- 250mg
- Price
- $22
- Updated
- 2021/12/16
METHYL 3-METHYLAMINOCROTONATE Chemical Properties,Usage,Production
Chemical Properties
white crystalline powder
Uses
It is employed as an intermediate in the synthesis of an analogue to amlodipine, bearing a short amino polyethylene glycol chain.
Synthesis
105-45-3
74-89-5
13412-12-9
1.2 g of silica gel was added to 11.6 g (100 mmol, 1 eq.) of methyl acetoacetate. To this was added 9.25 g (120 mmol, 1.2 eq.) of methylamine solution (40% aqueous solution) and the mixture was stirred overnight. The reaction mixture was extracted with dichloromethane (DCM), dried with anhydrous magnesium sulfate (MgSO?), filtered and the solvent was evaporated to give the yellow oily product methyl 3-(methylamino)but-2-enoate in 12.21 g, 95% yield.1H-NMR (CDCl?, δ/ppm): 8.47 (s, NH, 1H), 4.47 (s, CH, 1H). 3.61 (s, OCH?, 3H), 2.91 (d, NHCH?, J = 5.22 Hz, 3H), 1.92 (s, CH?, 3H).
References
[1] RSC Advances, 2015, vol. 5, # 49, p. 39193 - 39204
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 8, p. 1944 - 1947
[3] Patent: WO2013/25733, 2013, A1. Location in patent: Paragraph 0402
[4] Chemical and Pharmaceutical Bulletin, 1987, vol. 35, # 12, p. 4819 - 4828
[5] Bulletin de la Societe Chimique de France, 1923, vol. <4> 33, p. 1108
METHYL 3-METHYLAMINOCROTONATE Preparation Products And Raw materials
Raw materials
Preparation Products
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