4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

Product Name: 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
CAS No.: 1957235-66-3
Chemical Name: 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
Synonyms: Pomalidomide-C2-NH2;Thalidomide-4-NH-C2-NH2;4-[(2-Aminoethyl)amino]-2-(2;Cereblon Ligand-Linker Conjugates 15;Pomalidomide-C2-NH2(E3 ligase Ligand 17);4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl;1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-;4-[(2-aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione;Inhibitor,E3 Ligase Ligand-Linker Conjugates,PomalidomideC2NH2,Pomalidomide-C-2-NH2,inhibit,Pomalidomide C2 NH2
CBNumber: CB54796315
Molecular Formula: C15H16N4O4
Formula Weight: 316.31
MOL File: 1957235-66-3.mol

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4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Property

Boiling point:: 633.6±55.0 °C(Predicted)
Density: 1.496±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, protect from light
form: Solid
pka: 10.74±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: 027587
Product name: Pomalidomide-C2-NH2(E3ligaseLigand17)
Packaging: 001
Price: $450
Updated: 2021/12/16

Acrotein

Product number: AS00958
Product name: 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneHCl
Purity: 95%
Packaging: 1g
Price: $660
Updated: 2021/12/16

DC Chemicals

Product number: 027587
Product name: Pomalidomide-C2-NH2(E3ligaseLigand17)
Packaging: 002
Price: $850
Updated: 2021/12/16

DC Chemicals

Product number: 027587
Product name: Pomalidomide-C2-NH2(E3ligaseLigand17)
Packaging: 003
Price: $1700
Updated: 2021/12/16

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4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Chemical Properties,Usage,Production

Uses

Pomalidomide-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology.

IC 50

Cereblon

References

[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168

4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl manufacturers

Career Henan Chemical Co

Product: 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl 1957235-66-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 200kg
Release date: 2019-08-30

1957235-66-3, 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HClRelated Search:

E3 ligase Ligand-Linker Conjugates 49 Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid Pomalidomide-C6-PEG3-butyl iodide E3 ligase Ligand-Linker Conjugates 55 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Pomalidomide-6-2-2-6-N3 Pomalidomide-amido-C1-Br Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl POMALIDOMIDE-C9-CO2H Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Pomalidomide-C3-NH2 Pomalidomide-C6-NH2?hydrochloride Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-

4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Cereblon Ligand-Linker Conjugates 15

Pomalidomide-C2-NH2

1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-

Pomalidomide-C2-NH2(E3 ligase Ligand 17)

4-[(2-Aminoethyl)amino]-2-(2

Inhibitor,E3 Ligase Ligand-Linker Conjugates,PomalidomideC2NH2,Pomalidomide-C-2-NH2,inhibit,Pomalidomide C2 NH2

Thalidomide-4-NH-C2-NH2

4-[(2-aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione

1957235-66-3