ChemicalBook > CAS DataBase List > 4-Chlorobenzoic acid

4-Chlorobenzoic acid

Product Name
4-Chlorobenzoic acid
CAS No.
74-11-3
Chemical Name
4-Chlorobenzoic acid
Synonyms
74-11-3;PCBA;4-CHLOROBENZOATE;P-CHLOROBENZOIC ACID;Acemetacin impurity A CRS;4-chlorobenzoic;Indomethacin Related Compound B;Mycosid;NSC 8444;NSC 32738
CBNumber
CB5482423
Molecular Formula
C7H5ClO2
Formula Weight
156.57
MOL File
74-11-3.mol
More
Less

4-Chlorobenzoic acid Property

Melting point:
238-241 °C(lit.)
Boiling point:
274-276 °C
Density 
1.540
refractive index 
1.5812 (estimate)
Flash point:
238 °C
storage temp. 
room temp
solubility 
methanol: soluble1%, clear, colorless to faintly yellow
form 
Crystalline Powder
pka
3.98(at 25℃)
color 
White to yellow
PH
4.3 (0.08g/l, H2O, 20℃)
Water Solubility 
soluble in hot water
λmax
284nm(EtOH)(lit.)
Merck 
14,2125
BRN 
907196
Stability:
Stable. Combustible. Incompatible with bases, strong oxidizing agents.
InChIKey
XRHGYUZYPHTUJZ-UHFFFAOYSA-N
LogP
2.650
CAS DataBase Reference
74-11-3(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 4-chloro-(74-11-3)
EPA Substance Registry System
p-Chlorobenzoic acid (74-11-3)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
2
RTECS 
DG4976010
Autoignition Temperature
545 °C
TSCA 
Yes
HS Code 
29163900
Hazardous Substances Data
74-11-3(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 1170 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
135585
Product name
4-Chlorobenzoic acid
Purity
99%
Packaging
50g
Price
$42.1
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2581
Product name
Indomethacin Related Compound B
Purity
Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 50?mg
Packaging
50MG
Price
$534
Updated
2024/03/01
Sigma-Aldrich
Product number
1112423
Product name
Indomethacin Related Compound B
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1300
Updated
2024/03/01
Sigma-Aldrich
Product number
8.00476
Product name
4-Chlorobenzoic acid
Purity
for synthesis
Packaging
5G
Price
$33
Updated
2022/05/15
Sigma-Aldrich
Product number
8.00476
Product name
4-Chlorobenzoic acid
Purity
for synthesis
Packaging
250g
Price
$77.9
Updated
2022/05/15
More
Less

4-Chlorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder. Soluble in methanol, anhydrous ethanol and ether, very slightly soluble in water, toluene and 95% ethanol.

Uses

4-Chlorobenzoic acid is a benzoic acid analogue that showed antifungal activity against strains of Aspergillus flavus, Aspergillus fumigatus and Aspergillus terreus, causative agents of human aspergillosis, in in vitro bioas says. It is used as a preservative.
P-chlorobenzoic acid is the intermediate of fungicide dimethomorph, rodenticide Warfarin, Coumatetralyl and insecticide flumethrin, and also the intermediate of dye and medicine.

Uses

4-Chlorobenzoic acid can be used:
As a ligand to synthesize luminescent lanthanide complexes for bio-labeling or fiber communication applications.
To prepare organotin(IV) chlorobenzoates exhibiting anticorrosion properties.
As a ligand to synthesize di-n-butyl(4-chlorobenzoxy)(4-chlorobenzohydroxamato)tin(IV).

Preparation

4-Chlorobenzoic acid is obtained by oxidation of p-chlorotoluene: add potassium permanganate solution to the mixture of p-chlorotoluene and water in stages. The reaction is refluxed under stirring for 5-6h, then acidified with hydrochloric acid to pH 2, filtered to obtain the crude product, and recrystallized with ethanol to obtain the finished product.

Definition

ChEBI: 4-chlorobenzoic acid is a monochlorobenzoic acid carrying a chloro substituent at position 4. It has a role as a bacterial xenobiotic metabolite. It derives from a benzoic acid. It is a conjugate acid of a 4-chlorobenzoate.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 135, 1943
Synthetic Communications, 25, p. 3695, 1995 DOI: 10.1080/00397919508015507
Tetrahedron Letters, 22, p. 1013, 1981 DOI: 10.1016/S0040-4039(01)82853-7

General Description

Triclinic crystals or light fluffy white powder.
4-Chlorobenzoic acid is a degradation product of indomethacin. It is degraded by Acinetobacter sp. strain ST-1 and causes its dehalogenation to yield 4-hydroxybenzoic acid under both aerobic and anaerobic conditions.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

4-Chlorobenzoic acid is incompatible with strong oxidizing agents and strong bases.

Fire Hazard

Flash point data for 4-Chlorobenzoic acid are not available; however, 4-Chlorobenzoic acid is probably combustible.

Purification Methods

Purify it as for m-chlorobenzoic acid. It has also been crystallised from hot water, and from EtOH. [Beilstein 9 IV 973.]

4-Chlorobenzoic acid Preparation Products And Raw materials

Raw materials

Potassium permanganate 4-Chlorotoluene

Preparation Products

Moclobemide 4-Chloro-3,5-dinitrobenzoic acid 2-Amino-5-nitrobenzophenone 3-Amino-4-methoxybenzanilide 4-Chloro-3-nitrobenzoic acid 4-Chlorobenzoyl chloride Bumetanide
More
Less

4-Chlorobenzoic acid Suppliers

Americas 1 Belgium 1 Canada 4 China 492 Czech Republic 1 Europe 4 France 2 Germany 10 India 67 Japan 8 Slovakia 1 South Korea 1 Switzerland 3 Ukraine 2 United Kingdom 12 United States 54 Global 663
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
133-96369453 18678026865
Fax
0536-2101172
Email
sdfantai@163.com
Country
China
ProdList
862
Advantage
58
Shanghai TongYuan Chemical Co., Ltd.
Tel
021-021-69182866 13701855675
Fax
021-69182022
Email
tongyuanchem@126.com
Country
China
ProdList
4321
Advantage
58
Nantong Lianyi Chemical CO.,LTD.
Tel
0513-81188185 13861935768
Email
ourui@lyhgchem.com
Country
China
ProdList
4
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Rudong Zhongyi Chemical Co., Ltd
Tel
13306234115
Fax
+86-0513-84819568
Email
jszyzj@zhongyichem.com
Country
China
ProdList
36
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9413
Advantage
66
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8843
Advantage
52
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Aemon Chemical
Tel
0086-755-86198205
Email
acinfo@aemonchem.com
Country
China
ProdList
1931
Advantage
57
ZhangJiaGang YaRui Chemical Co.,Ltd.
Tel
0512-58961066 18921980669
Fax
0512-58961068
Email
sales@yaruichem.com
Country
China
ProdList
40
Advantage
62
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Beijing Taiya Jie Technology Development Co., Ltd.
Tel
021-33690831-8001 13552411790
Fax
021-33690831
Email
postmaster@tyjchem.cn
Country
China
ProdList
1541
Advantage
55
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5047
Advantage
50
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
Tel
022-60116533 13207668525
Fax
022-60979672
Email
saleskc@scipharmacn.com
Country
China
ProdList
684
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6134
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3224
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Zouping Mingxing Chemical Co.,Ltd.
Tel
86-13605431940 13605431940
Fax
0086-0543-2240079
Email
zpmxchemical@126.com
Country
China
ProdList
1999
Advantage
62
Wuxi Zhangkun Biochemical Technology Co., Ltd.
Tel
+86 0510-85629785
Fax
+86 0510-85625359
Country
China
ProdList
2327
Advantage
58
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3930
Advantage
58
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3583
Advantage
55
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
More
Less

View Lastest Price from 4-Chlorobenzoic acid manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
4-Chlorobenzoic acid 74-11-3
Price
US $99.00-66.00/kg
Min. Order
0.0010000000474974513kg
Purity
99%
Supply Ability
5000
Release date
2024-08-19
Speranza Chemical Co., Ltd.
Product
4-Chlorobenzoic acid 74-11-3
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
300MT/year
Release date
2019-12-24
Hebei Weibang Biotechnology Co., Ltd
Product
4-Chlorobenzoic acid 74-11-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100
Release date
2024-11-19

74-11-3, 4-Chlorobenzoic acidRelated Search:

4-Chloro-N-(4-Methoxyphenyl)benzaMide, 97% 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-hydroxypropyl ester 4-Chloro-2-(4-chlorobenzoyl)-1-(4-Methoxyphenyl)hydrazide Benzoic Acid 5-METHOXY-2-METHYL-3-INDOLEACETIC ACID Benzoic acid, 4-chloro-, 2,3-dihydroxypropyl ester 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-, ethyl ester 1H-INDOLE-3-ACETICACID,1-(3-CHLOROBENZOYL)-5-METHOXY-2-METHYL 2-(4-METHOXYPHENYL)HYDRAZINESULFONIC ACID SODIUM SALT MONOHYDRATE IndoMethacin DiaMide methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-,2,3-d ihydroxypropyl ester Indometacin EP Impurity G 4-Chlorobenzonitrile 4-Chlorobenzaldehyde 4-Chloroanisole Indometacin Impurity 17 Methanone, (4-chlorophenyl)[2,6-dichloro-4-(hydroxymethyl)phenyl]- Indometacin

  • Indometacin EP Impurity A
  • Indomethacin EP Impurity A
  • Acemetacin Impurity 1（Acemetacin EP Impurity A）
  • Bezafibrate Impurity 2（Bezafibrate EP Impurity B）
  • Indomethacin USP RC B
  • AKOS 92635
  • AKOS BBS-00003713
  • RARECHEM AL BO 0054
  • PCBA
  • P-CHLOROBENZOIC ACID
  • 4-Chlorbenzoesαure
  • 4-chlorobenzoic
  • 4-chloro-benzoicaci
  • Acido p-clorobenzoico
  • acidop-clorobenzoico
  • Benzoic acid, p-chloro-
  • benzoicacid,4-chloro-
  • p-CHLOROBENZOIC ACID pure
  • 4-Chlorobenzoic acid,99%
  • p-Chorobenzoic acid
  • 4-Chlorobenzoic acid, 99% 250GR
  • 4-Chlorobenzoic acid, 99% 25GR
  • Mycosid
  • NSC 143358
  • NSC 32738
  • NSC 8444
  • 4-CHLOROBENZOIC ACID FOR SYNTHESIS
  • 4-chlorobenzoic aicd
  • 74-11-3
  • 4-Chlorobenzoic acid Vetec(TM) reagent grade, 98%
  • Of chlorobenzoic acid
  • 4-Chlorobenzoi
  • 'LGC' (4004)
  • LABOTEST-BB LT00776185
  • CHLORODRACYLIC ACID
  • 4-CHLOROBENZOIC ACID
  • para-chlorobenzoicacid
  • p-Carboxychlorobenzene
  • p-Chlorbenzoic acid
  • p-chlorbenzoicacid
  • p-chlorobenzoic
  • p-chloro-benzoicaci
  • 4- Chlorobenzoic acid (p-Chlorobenzoic acid)
  • 4-CHLOROBENZOIC ACID, 1000MG, NEAT
  • ChlorocholineChloride50%AqueousSolution
  • 4-Chlorobenzoic acid, 98+%
  • 4-CHLOROBENZOATE
  • Chlorodracyclic acid
  • Indomethacin Related Compound B
  • p-CHLOROBENZOIC ACID extrapure AR
  • 4-Chlorobenzoic Acid (Indomethacin Impurity)
  • Acemetacin impurity A CRS
  • Bezafibrate EP Impurity B
  • Indomethacin Impurity 15
  • Indomethacin EP Impurity A/ Indomethacin Related Compound B (Acemetacin EP Impurity A/ Bezafibrate EP Impurity B)
  • Bezafibrate EP Impurity B (Acemetacin EP Impurity A/ Indomethacin EP Impurity A/ Indomethacin Related Compound B)
  • Acemetacin EP Impurity A (Indomethacin EP Impurity A/ Indomethacin Related Compound B/ Bezafibrate EP Impurity B)
  • Indometacin Impurit Ⅱ:4-Chlorobenzoic acid