MEQUITAZINE

Product Name: MEQUITAZINE
CAS No.: 29216-28-2
Chemical Name: MEQUITAZINE
Synonyms: Butix;LM 209;Mircol;MQ-A-88;Vigigan;Zesulan;Instotal;Primalan;Virginan;Nipolazin
CBNumber: CB5487473
Molecular Formula: C20H22N2S
Formula Weight: 322.47
MOL File: 29216-28-2.mol

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MEQUITAZINE Property

Melting point:: 143-145°C
Boiling point:: 469.4±24.0 °C(Predicted)
Density: 1.1330 (rough estimate)
refractive index: 1.5800 (estimate)
storage temp.: Refrigerator
Water Solubility: Insoluble in water
solubility: DMSO : 16 mg/mL (49.62 mM)
form: powder to crystal
pka: 10.43±0.33(Predicted)
color: White to Almost white
Merck: 14,5864
CAS DataBase Reference: 29216-28-2(CAS DataBase Reference)
NIST Chemistry Reference: Mequitazine(29216-28-2)

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Safety

RIDADR: UN 2811 6.1/PG III
RTECS: SP5080000
HazardClass: 6.1
PackingGroup: III
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2807
Product name: Mequitazine
Purity: >98.0%(GC)(T)
Packaging: 100mg
Price: $69
Updated: 2024/03/01

TCI Chemical

Product number: M2807
Product name: Mequitazine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $208
Updated: 2024/03/01

TRC

Product number: M225110
Product name: Mequitazine
Packaging: 100mg
Price: $485
Updated: 2021/12/16

TRC

Product number: M225110
Product name: Mequitazine
Packaging: 50g
Price: $1090
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA25075
Product name: 10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine
Packaging: 25g
Price: $375
Updated: 2021/12/16

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MEQUITAZINE Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Primalan,Berk,UK,1976

Uses

It is an antihistamine

Definition

ChEBI: Mequitazine is a member of phenothiazines.

Manufacturing Process

30 g of phenothiazine were added, all at once, to a suspension of 6 g of sodium amide in 240 ml of anhydrous xylene. The mixture was agitated and heated to reflux. When evolution of ammonia ceased (5 hours), 15 g of 3- chloromethyl-quinuclidine hydrochloride were added portionwise over a period of 50 minutes and reflux was then maintained for 22 hours. After cooling to room temperature, 250 ml of distilled water and 250 ml of ethyl acetate were added to the reaction mixture. The aqueous phase was decanted and extracted twice with a total of 250 ml of methyl acetate. The combined organic extracts were extracted three times with a total of 750 ml of a 10% aqueous solution of tartaric acid. The combined acid solutions were treated with 5 g of animal charcoal, filtered and rendered alkaline on an ice bath with 96 ml of 10 N aqueous caustic soda. The oil which separated was extracted three times with a total of 1.500 ml of ethyl acetate. The combined organic extracts were washed to neutrality by washing twice with a total of 1 liter of distilled water, dried over anhydrous magnesium sulfate and evaporated under reduced pressure on a water bath at 45°C. 17 g of oil were obtained which was purified by chromatography on an inert alumina column. 13.3 g of crystallized product were obtained. 10-(3-Quinuclidinyl-methyl)-phenothiazine having a MP of 130°C to 131°C was obtained by recrystallization in boiling acetonitrile.
The 3-chloromethyl-quinuclidine hydrochloride used as starting material in this process can be obtained as described by Grob and coll., Helv. Chim. Acta, 37 (1954),1689.

Therapeutic Function

Antihistaminic

MEQUITAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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MEQUITAZINE Suppliers

Americas 1 Canada 1 China 114 Europe 3 Germany 1 India 3 Japan 1 South Korea 1 United Kingdom 6 United States 20 Global 151

LGM Pharma

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TargetMol Chemicals Inc.

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AlliChem, LLC

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Medical Isotopes

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3B Scientific Corporation

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APAC Pharmaceutical, LLC

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ChemPacific Corporation

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View Lastest Price from MEQUITAZINE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Mequitazine 29216-28-2
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 98.5%min
Supply Ability: 10kg
Release date: 2021-08-05

Baoji Guokang Bio-Technology Co., Ltd.

Product: MEQUITAZINE 29216-28-2
Price: US $3015.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 5kg
Release date: 2021-06-04

Zhuozhou Wenxi import and Export Co., Ltd

Product: MEQUITAZINE 29216-28-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

29216-28-2, MEQUITAZINERelated Search:

Mertansine Clindamycin Brompheniramine Trimethobenzamide Danazol Loratadine Antazoline Phenothiazine (R)-(+)-Mequitazine 1-(2,6-DICHLOROPHENYL)-2-INDOLINONE /MEQUITAZINE mequitazine sulfoxide MEQUITAZINE, [2-14C]- pecazine MEQUITAZINE Trimeprazine

10-(1-Azabicyclo[2.2.2]octan-3-ylmethyl)-10H-phenothiazine

10-(Quinuclidin-3-ylmethyl)-10H-phenothiazine

MQ-A-88

10-[(1R,3R)-1-azabicyclo[2.2.2]octan-3-ylMethyl]-10H-phenothiazine

10H-Phenothiazine, 10-(1-azabicyclo[2.2.2]oct-3-ylmethyl)- (9CI)

Nipolazin

NSC 303612

Phenothiazine, 10-(3-quinuclidinylmethyl)- (8CI)

Quitadrill

10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine

10-(3-Quinuclidinylmethyl)phenothiazine

Butix

Instotal

LM 209

Mequitazina

Metaplexan

Mircol

Phenothiazine, 10-(3-quinuclidinylmethyl)-

10-(1-azabicyclo[2.2.2]octan-3-ylmethyl)phenothiazine

Primalan

Vigigan

Virginan

Zesulan

MEQUITAZINE

10H-PHENOTHIAZINE, 10-(1-AZABICYCLO[2.2.2]OCT-3-YLMETHYL)-

MEQUITAZINE USP/EP/BP

Indomethacin BP

Butix Powder USP Standard

29216-28-2

C20H22N2S

Heterocyclic Compounds

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals