Dermorphin
Structure- Product Name
- Dermorphin
- CAS No.
- 77614-16-5
- Chemical Name
- Dermorphin
- Synonyms
- DERMORPHIN;Dermorphin HAc;Dermorphin Powder;DERMORPHIN ACETATE;dermorphin/DERMORPHIN ACETATE;Dermorphin trifluoroacetate salt;L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2;Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide;(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro;(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide
- CBNumber
- CB5498044
- Molecular Formula
- C40H50N8O10
- Formula Weight
- 802.87
- MOL File
- 77614-16-5.mol
Dermorphin Property
- Melting point:
- 157-159 °C
- Boiling point:
- 1323.8±65.0 °C(Predicted)
- Density
- 1.363±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO
- pka
- 9.83±0.15(Predicted)
- form
- powder
- color
- white to off-white
- Sequence
- H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
- InChI
- InChI=1S/C40H50N8O10/c1-23(44-37(55)29(41)18-25-9-13-27(50)14-10-25)36(54)46-30(19-24-6-3-2-4-7-24)38(56)43-21-34(52)45-31(20-26-11-15-28(51)16-12-26)40(58)48-17-5-8-33(48)39(57)47-32(22-49)35(42)53/h2-4,6-7,9-16,23,29-33,49-51H,5,8,17-22,41H2,1H3,(H2,42,53)(H,43,56)(H,44,55)(H,45,52)(H,46,54)(H,47,57)/t23-,29+,30+,31+,32+,33+/m1/s1
- InChIKey
- FHZPGIUBXYVUOY-VWGYHWLBSA-N
- SMILES
- C(N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N)(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1)CC1C=CC(O)=CC=1
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- J62019
- Product name
- Dermorphin
- Packaging
- 5mg
- Price
- $194
- Updated
- 2021/12/16
- Product number
- CS-7103
- Product name
- Dermorphin
- Purity
- 99.64%
- Packaging
- 10mg
- Price
- $216
- Updated
- 2021/12/16
- Product number
- FD108711
- Product name
- Dermorphin
- Packaging
- 250mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FD108711
- Product name
- Dermorphin
- Packaging
- 500mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- PEP0001209
- Product name
- DERMORPHIN
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $427.2
- Updated
- 2021/12/16
Dermorphin Chemical Properties,Usage,Production
Structure
Dermorphin does not contain the common N-terminal sequence for the traditional endogenous opioid peptides (Tyr–Gly–Gly–Phe), and its sequence is completely different from those of the endomorphins, which were identified as endogenous μ-opioid peptides that also do not contain the common sequence. Interestingly, DM contains D-alanine (a D-isomer amino acid) in its sequence. The primary structure of dermorphin is YDAFGYPS-NH2.
Description
Dermorphin was first isolated from the skin of the skin of South American frogs of the genus Phyllomedusa. It is a high potency natural opiate peptide that binds selectively to mu-opioid receptors.
Uses
A mu-opioid receptor agonist
Definition
ChEBI: Dermorphin is an oligopeptide.
Side effects
Like μ-opiate agonists, dermorphins produce antinociception and also catalepsy, respiratory depression, constipation, tolerance, and dependence, although at a lower degree than morphine does[1].
in vitro
Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor.
References
[1] Negri, L. P. Melchiorri and R. Lattanzi. “Opioid and Bv8 Peptides.”Handbook of Biologically Active Peptides (Second Edition) 2013:376-383.
Dermorphin Preparation Products And Raw materials
Raw materials
Preparation Products
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- 18115476705
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View Lastest Price from Dermorphin manufacturers
- Product
- dermorphin 77614-16-5
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 99%
- Supply Ability
- 20
- Release date
- 2024-10-17
- Product
- dermorphin? 77614-16-5
- Price
- US $60.00-40.00/box
- Min. Order
- 1box
- Purity
- 99.99%
- Supply Ability
- 1000
- Release date
- 2024-03-14
- Product
- DERMORPHIN ACETATE 77614-16-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2024-03-26