ChemicalBook > CAS DataBase List > DMT-2'O-Methyl-rU Phosphoramidite

DMT-2'O-Methyl-rU Phosphoramidite

Product Name
DMT-2'O-Methyl-rU Phosphoramidite
CAS No.
110764-79-9
Chemical Name
DMT-2'O-Methyl-rU Phosphoramidite
Synonyms
2'-OMe-U amidite;2’-OMe -dU Amidite;5'-O-DMT-2'-OMe-U-CE;Cytidine Impurity 15;2'-OMe-Uridine Amidite;2'-OMe-Uridine Amidite;2'-OMe-U Phosphoramidite;2'-OMe-rU Phosphoramidite;2'-OMe-U-CE-Phosphoramidite;5'-O-DMT-2'-O-Me-rU-3'-CEDPA
CBNumber
CB5500323
Molecular Formula
C40H49N4O9P
Formula Weight
760.82
MOL File
110764-79-9.mol
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DMT-2'O-Methyl-rU Phosphoramidite Property

storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO : 100 mg/mL (131.44 mM; Need ultrasonic)
form 
powder
pka
9.39±0.10(Predicted)
color 
white to off-white
InChI
InChI=1/C40H49N4O9P/c1-27(2)44(28(3)4)54(51-25-11-23-41)53-36-34(52-38(37(36)49-7)43-24-22-35(45)42-39(43)46)26-50-40(29-12-9-8-10-13-29,30-14-18-32(47-5)19-15-30)31-16-20-33(48-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,46)/t34-,36-,37-,38-,54?/s3
InChIKey
UVUOJOLPNDCIHL-XKZJCBTISA-N
SMILES
C(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)(C1C=CC(OC)=CC=1)OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC)[C@@H]1OP(OCCC#N)N(C(C)C)C(C)C |&1:25,27,36,39,r|
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
U211180
Product name
DMT-2′O-Methyl-rU Phosphoramidite
Purity
configured for PerkinElmer, configured for Polygen
Packaging
1G
Price
$81.4
Updated
2024/03/01
Sigma-Aldrich
Product number
U211150
Product name
DMT-2′O-Methyl-rU Phosphoramidite
Purity
configured for ?KTA? and OligoPilot?
Packaging
2g
Price
$181
Updated
2024/03/01
Sigma-Aldrich
Product number
U211100
Product name
DMT-2′O-Methyl-rU Phosphoramidite
Purity
≥99% (31P-NMR)
Packaging
500g
Price
$32550
Updated
2024/03/01
Sigma-Aldrich
Product number
U211100
Product name
DMT-2′O-Methyl-rU Phosphoramidite
Purity
≥99% (31P-NMR)
Packaging
100g
Price
$8080
Updated
2022/05/15
Sigma-Aldrich
Product number
U211180
Product name
DMT-2′O-Methyl-rU Phosphoramidite
Purity
configured for PerkinElmer, configured for Polygen
Packaging
0.5g
Price
$92.7
Updated
2024/03/01
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DMT-2'O-Methyl-rU Phosphoramidite Chemical Properties,Usage,Production

Characteristics

DMT-2′O-Methyl-rU Phosphoramidite belongs to the class of 2′O-Methyl RNA Phosphoramidites. Its key features include:
High yield of crude oligonucleotides Compatible with DNA synthesis;
Can be employed together with DNA or RNA phosphoramidites in the same synthesis to produce mixmer oligonucleotides;
Recommended deprotection conditions are 8 hours at 55 deg C using concentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 deg C;
Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as no special precautions are required to provide protection against nucleolytic degradation;
Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers);
2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry.

Uses

DMT-2'O-Methyl-rU Phosphoramidite is a white to off-white powder and is used as a pharmaceutical intermediate for pharmaceutical synthesis and scientific research.

Application

2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rU Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules

DMT-2'O-Methyl-rU Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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DMT-2'O-Methyl-rU Phosphoramidite Suppliers

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View Lastest Price from DMT-2'O-Methyl-rU Phosphoramidite manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.
Product
5'-O-DMT-2'-OMe-U-CE 110764-79-9
Price
US $0.00/mg
Min. Order
100mg
Purity
≥98%
Supply Ability
20tons
Release date
2023-03-09
R&D Scientific Inc.
Product
5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite 110764-79-9
Price
US $600.00/g
Min. Order
1g
Purity
98
Supply Ability
500 Kg
Release date
2024-02-11
SHANGHAI NOVRIBO BIOTECH
Product
2'-OMe-U CE Phosphoramidite 110764-79-9
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-20

110764-79-9, DMT-2'O-Methyl-rU PhosphoramiditeRelated Search:

3-Chloropropyltrimethoxysilane Trimethoxypropylsilane 3-Mercaptopropyltriethoxysilane UMP 1-beta-D-Arabinofuranosyluracil N,N-Diisopropylethylamine Trifluridine Doxifluridine Ac-rC Phosphoramidite DMT-2′O-TBDMS-rU Phosphoramidite DMT-dT Phosphoramidite 2'-O-Methyluridine Uridine L-Uridine FLUORESCEIN-DT CEP N-blocked-5'-O-DMT 3'-CED iododeoxyuridine phosphoramidite 5-[E-2-[N-[N-[N1-(4-T-BUTYLBENZOYL)-D-(+)-BIOTINYL]-6-AMINOHEXYL]CARBOXAMIDO]VINYL]-5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYURIDINE, 3'-[(2-CYANOETHYL)-(N,N-DIISOPROPYL)]PHOSPHORAMIDITE 2'-O-METHYL-5-METHYL-U CEP

  • 3-({[(2-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-5-(2,4-DIOXO-3H-PYRIMIDIN-1-YL)-4-METHOXYOXOLA
  • DMT-2'O-ME-RU AMIDITE 0.5G 89 SINGLE
  • 2'-O-methyluridine-ce phosphoramidite*for abi
  • DMT-2'O-Me-rU Amidite 10g, Single
  • DMT-2'O-ME-RU AMIDITE 0.5G AB SINGLE
  • 2’-O-Methy-rUPhosphoramidite
  • N-blocked-5'-O-DMT-2'-O-Me CED uridine phosphoramidite
  • 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 5'-O-DMT-2'-O-Me-rU-3'-CEDPA
  • 5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite
  • 2'-Deoxy-2'-O-Me-5'-O-DMT-Uridine-3'-CED PhosphoraMidite
  • Uridine, 5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-O-Methyl-, 3'-[2-cyanoethyl bis(1-Methylethyl)phosphoraMidite]
  • DMT-2′O-Methyl-rU Phosphoramidite
  • 2'-O-Methyl-rU phosphoramidite
  • 5'-DMT-2'-OMe-rU Phosphoramidite
  • 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine 3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite
  • 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidit
  • 5'-O-(4, 4'-Dimethoxytrityl)-2'-O-methyl-Uridine-3'-CE-Phosphoramidite
  • Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • 5'-Dimethoxytrityl-Uridine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • 5'-DMTr-2'-O-Me-3'-O-CEP-URIDINE
  • 5'-O-DMT-2'-OMe-rU Phosphoramidite
  • 5'-O-DMT-2'-OMe-Uridine-CE Phosphoramidite
  • 2'-OMe-U amidite
  • DMT-2-O-ME-U-CE Phosphoramidite
  • DMT-2'-O-Me-U Phosphoramidite
  • 5'-O-DMT-2'-OMe-U-CE
  • 5'-O-DMT-2'-OMe- Uridine -3’-Cyanoethyl Phosphoramidite
  • 2'-OMe-Uridine Amidite
  • DMTr-2'-O-Me-rU-3'-CE-Phosphoramidite
  • 2’-OMe -dU Amidite
  • 5'-ODMT-2'-OMe Uridine-3'-OCEPA
  • 2'-OMe-U Phosphoramidite
  • DMT-2'O-Methyl-rU Phosphoramidite
  • DMT-2'-O-Me-U-CE Phosphoramidite
  • 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxy-tetrahydrofuran-3-yl]oxy-(diisopropylamino)phosphanyl]oxypropanenitrile
  • 5'-O-DMT-2'-OMe-Uridine-CE Phosphoramidite
  • 2'-OMe-U-CE-Phosphoramidite
  • 2'-O-Methyl Uridine CED Phosphoramidite
  • 2'-O-Me-5'-O-DMT-U-3'-CE-Phosphoramidite
  • 2'-OMe-rU Phosphoramidite
  • 5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite
  • 2'-Deoxy-2'-O-Me-5'-O-DMT-Uridine-3'-CED Phosphoramidite
  • 5'-O-DMT-2'-OMe- Uridine -3’-Cyanoethyl Phosphoramidite
  • 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 2'-OMe-Uridine Amidite
  • Cytidine Impurity 15
  • 110764-79-9