ChemicalBook > CAS DataBase List > Travoprost

Travoprost

Product Name
Travoprost
CAS No.
157283-68-6
Chemical Name
Travoprost
Synonyms
Trovoprost;Trivo;FLU-IPR;AL 6221;Travatan;ravopros;Trivoprost;Travaprost;TRAVOPROST;Travoprostt
CBNumber
CB5703458
Molecular Formula
C26H35F3O6
Formula Weight
500.55
MOL File
157283-68-6.mol
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Travoprost Property

alpha 
D20 +14.6° (c = 1.0 in methylene chloride)
Boiling point:
584.8±50.0 °C(Predicted)
Density 
1.245±0.06 g/cm3(Predicted)
Flash point:
17 °C
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Dichloromethane (Sparingly, Sonicated), Chloroform (Sparingy), Methanol (Sparing
form 
ethanol solution
pka
13.43±0.20(Predicted)
color 
Colourless to Light Beige
BCS Class
2
Stability:
Light Sensitive
InChIKey
MKPLKVHSHYCHOC-AHTXBMBWSA-N
CAS DataBase Reference
157283-68-6(CAS DataBase Reference)
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Safety

Hazard Codes 
F,Xi
Risk Statements 
11-36/37/38
Safety Statements 
16-26-36-7
RIDADR 
UN 1170 3/PG 2
WGK Germany 
1
HS Code 
2937500000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1622
Product name
Travoprost
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
3mL
Price
$173
Updated
2024/03/01
Sigma-Aldrich
Product number
1673001
Product name
Travoprost
Packaging
3ml
Price
$436
Updated
2024/03/01
Cayman Chemical
Product number
16769
Product name
Fluprostenol isopropyl ester
Purity
≥98%
Packaging
1mg
Price
$70
Updated
2024/03/01
Cayman Chemical
Product number
16769
Product name
Fluprostenol isopropyl ester
Purity
≥98%
Packaging
5mg
Price
$308
Updated
2024/03/01
Cayman Chemical
Product number
16769
Product name
Fluprostenol isopropyl ester
Purity
≥98%
Packaging
10mg
Price
$545
Updated
2024/03/01
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Travoprost Chemical Properties,Usage,Production

Description

Travoprost was launched in the US as Travatan?, an ophthalmic solution (0.004%) administered topically for the treatment of elevated intraocular hypertension (lOP) through open-angle glaucoma, a common optic neuropathy and a leading cause of blindness. Travoprost is the isopropyl ester of (+)-fluprostenol, a new prostaglandin derivative belonging to the PGF2α, analog class. This compound can be prepared in 8 steps from a bicyclic lactone aldehyde by a Wittig alkylidenation followed, after 2 ketonic reductions, by a lactol opening to prostenoic acid while protecting and deprotecting appropriately. Travoprost is a full agonist of FP receptors with a greater affinity than PGF2α, (K1 = 52 nM). Pharmacologic studies in rabbits treated daily for a week demonstrated a significant increase of the microvascular optic nerve head blood flow without significant alterations in the systemic flow. In several placebo-controlled clinical studies with hundreds of patients suffering from open-angle glaucoma or ocular hypertension, travoprost (1 to 4 pm daily) dose-dependently reduced lOP (by about 30% at 4 pm); it was shown equal or superior to latanoprost, another prostaglandin analog (5 pm daily) or the adrenergic ~-blocker timolol (500 pm bid). In addition, travoprost was safe and well tolerated with a low incidence of conjunctival hyperaemia.

Chemical Properties

Colorless Oil

Originator

Alcon (US)

Uses

Travoprost is a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).

Uses

treatment conditions arising from excess uric acid, eg chronic gout

Uses

Selective FP prostaglandin receptor agonist. Isopropyl ester of (+)-fluprostenol. Antiglaucoma

Definition

ChEBI: The isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophth lmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the co nea to the biologically active free acid, fluprostenol.

brand name

Travatan

General Description

Travoprost (Travatan and Travatan-Z) is supplied asa 2.5- or 5.0-mL sterile 0.004% ophthalmic solution in a4.0- or 7.5-mL size container. Travoprost is claimed to bethe most potent and FP-specific analog in this product category. Cautions and side effects are similar to those givenpreviously.

Travoprost Preparation Products And Raw materials

Raw materials

Preparation Products

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Travoprost Suppliers

Argentina 1 Canada 4 China 274 Czech Republic 2 Europe 2 France 2 Germany 7 Greece 1 Hungary 1 India 60 Ireland 1 Israel 2 Italy 3 Malaysia 1 Mexico 1 Philippines 1 Saudi Arabia 1 Singapore 1 South Korea 3 Spain 1 Switzerland 3 United Arab Emirates 1 United Kingdom 5 United States 36 Global 414
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View Lastest Price from Travoprost manufacturers

Sinoway Industrial co., ltd.
Product
Travoprost 157283-68-6
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
USP32
Supply Ability
20 tons
Release date
2021-07-13
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Travoprost 157283-68-6
Price
US $0.00/g
Min. Order
1g
Purity
96%-102%
Supply Ability
100G
Release date
2021-07-07
Wuhan Quanjinci New Material Co.,Ltd.
Product
Travoprost 157283-68-6
Price
US $35.00/L
Min. Order
1L
Purity
0.99
Supply Ability
1000000tons
Release date
2023-11-29

157283-68-6, TravoprostRelated Search:

Anisole Glycolic acid CHLOROPHOSPHONAZO III (Trifluoromethoxy)benzene Methylparaben Prostaglandin E2 Hydroxy silicone oil Epoprostenol Propane HYDROXYAPATITE TYPE I 4-Hydroxybenzaldehyde Prostaglandin E1 Bimatoprost Latanoprost (+)-Fluprostenol 9-KETO FLUPROSTENOL 9-keto Fluprostenol isopropyl ester 15-Keto Travoprost

  • (+)-9ALPHA,11ALPHA,15R-TRIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER
  • (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid 1-methyethyl ester
  • (+/-)-16-(M-TRIFLUOROMETHYLPHENOXY)TETRANORPROSTAGLANDIN F2
  • 15(S)-FLU-IPR
  • 15(S)-FLUPROSTENOL ISOPROPYL ESTER
  • 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-, 1-methylethyl ester, (5Z)-
  • trevostaglandin
  • Travoprost Eye Drops
  • Travoprost（Fluprostenol Isopropyl Ester）
  • propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
  • Trivo
  • Trivoprost
  • 9ALPHA,11ALPHA,15S-TRIHYDROXY-16(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER
  • (+)-FLUPROSTENOL ISOPROPYL ESTER
  • FLUPROSTENOL ISOPROPYL ESTER
  • FLU-IPR
  • propan-2-yl (e)-7-[(1r,2s,3r,5s)-3,5-dihydroxy-2-[(e)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
  • (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester
  • AL 6221
  • Travaprost
  • Travatan
  • TRAVOPROST
  • propan-2-yl 7-[(1R,2S,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
  • Travoprost (For eye drops)
  • cGMP Travoprost
  • propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]but-1-en-1-yl]cyclopentyl]hept-5-enoate
  • (4-isopropyloxcarbonylbutyl)dipenhylphosphine oxide
  • Travoprost, (±)-16-(m-Trifluoromethylphenoxy)tetranorprostaglandin F2
  • Travoprostintermediates
  • Travoprost (AL-6221)
  • (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]buten-1-yl][cyclopentyl]hept-5-enoate
  • Travoprost, >=99%
  • Travoprost Impurity 33
  • Travoprost USP/EP/BP
  • Trovoprost
  • isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate
  • Travoprostum
  • (Z)-Isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R,E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoate
  • Travoprost D7
  • TravoprostQ: What is Travoprost Q: What is the CAS Number of Travoprost Q: What is the storage condition of Travoprost Q: What are the applications of Travoprost
  • Travoprost (COLD SHIPMENT REQUIRED) (1673001)
  • ravopros
  • Travoprostt
  • Travoprost API
  • Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(R,E)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoate
  • 7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-(5Z)-5-heptenoic acid 1-methylethyl ester
  • 157283-68-6
  • 157283-62-7
  • C26H35F3O6
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Prostaglandins
  • Prostaglandin