H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
- Product Name
- H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
- CAS No.
- 143413-47-2
- Chemical Name
- H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
- Synonyms
- (ARG)9;RRRRRRRRR;Peptide R9;R 9 peptide;Nonaarginine;(Arg)9 peptide;H-RRRRRRRRR-NH2;Poly Arginine 9;Nona-L-arginine;R9/Nonaarginine
- CBNumber
- CB5706464
- Molecular Formula
- C54H110N36O10
- Formula Weight
- 1423.69
- MOL File
- 143413-47-2.mol
H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Property
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- Sequence
- H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH
N-Bromosuccinimide Price
- Product number
- AR009BQF
- Product name
- H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
- Purity
- 97%
- Packaging
- 100mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- AR009BQF
- Product name
- H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
- Purity
- 97%
- Packaging
- 250mg
- Price
- $326
- Updated
- 2021/12/16
H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Chemical Properties,Usage,Production
Biological Activity
(Arg)9 (Nona-L-arginine; Peptide R9) is a cell-permeable polypeptide with IC50 value of 0.78 μM for neuroprotection in a glutamate model experimental model.
in vitro
Poly-arginine (eg (Arg)9) and arginine-rich peptides (eg TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. It provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC 50 =0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC 50 =0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC 50 =6 μM).
in vivo
(Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after reduces permanent middle cerebral artery occlusion (MCAO) infarct volume .
target
IC50: 0.78 μM (neuroprotection)
H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Preparation Products And Raw materials
Raw materials
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View Lastest Price from H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH manufacturers
- Product
- H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH 143413-47-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-13