ChemicalBook > CAS DataBase List > H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH

Product Name
H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
CAS No.
143413-47-2
Chemical Name
H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
Synonyms
(ARG)9;RRRRRRRRR;Peptide R9;R 9 peptide;Nonaarginine;(Arg)9 peptide;H-RRRRRRRRR-NH2;Poly Arginine 9;Nona-L-arginine;R9/Nonaarginine
CBNumber
CB5706464
Molecular Formula
C54H110N36O10
Formula Weight
1423.69
MOL File
143413-47-2.mol
More
Less

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Property

Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
Sequence
H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Aaron Chemicals
Product number
AR009BQF
Product name
H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
Purity
97%
Packaging
100mg
Price
$220
Updated
2021/12/16
Aaron Chemicals
Product number
AR009BQF
Product name
H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
Purity
97%
Packaging
250mg
Price
$326
Updated
2021/12/16
More
Less

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Chemical Properties,Usage,Production

Uses

(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model[1][2].

Biological Activity

(Arg)9 (Nona-L-arginine; Peptide R9) is a cell-permeable polypeptide with IC50 value of 0.78 μM for neuroprotection in a glutamate model experimental model.

in vitro

Poly-arginine (eg (Arg)9) and arginine-rich peptides (eg TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. It provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC 50 =0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC 50 =0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC 50 =6 μM).

in vivo

(Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after reduces permanent middle cerebral artery occlusion (MCAO) infarct volume .

target

IC50: 0.78 μM (neuroprotection)

References

[1] Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9. DOI:10.1074/jbc.M003848200
[2] Meloni BP, et, al. The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014 Mar;34(2):173-81. DOI:10.1007/s10571-013-9999-3
[3] Meloni BP, et, al. Poly-arginine and arginine-rich peptides are neuroprotective in stroke models. J Cereb Blood Flow Metab. 2015 Jun;35(6):993-1004. DOI:10.1038/jcbfm.2015.11

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH Suppliers

China 85 United States 9 Global 94
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Avantpbc Chemical Tech(Shanghai) Co,Ltd.
Tel
17802107445
Country
China
ProdList
185
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 15951641583
Fax
025-58361106-806
Email
zhao.xu@njpeptide.com
Country
China
ProdList
9979
Advantage
55
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4802
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
7408
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3061
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
Henan Alfa Chemical Co., Ltd
Tel
+8615838112936
Email
alfa10@alfachem.cn
Country
China
ProdList
12921
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Hangzhou Go Top Peptide Biotech
Tel
0571-88211921
Email
sales1@gotopbio.com
Country
CHINA
ProdList
2609
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29798
Advantage
58
Nanjing chengqimei Biotechnology Co., Ltd
Tel
19850819832
Email
2173594524@qq.com
Country
China
ProdList
2638
Advantage
58
Nanchang Tianzhen Biotechnology Co., Ltd
Tel
13758194781 13173652190
Email
522013271@qq.com
Country
China
ProdList
2395
Advantage
58
Wuxi Helen Biotechnology Co., Ltd.,
Tel
0510-85629785 18013409632
Fax
0510-85625359
Email
sales@reading-chemicals.com
Country
China
ProdList
14081
Advantage
58
Nanjing TGpeptide Biotechnology Co.,Ltd.
Tel
18115476705
Email
sales@tgpeptide.com
Country
China
ProdList
3058
Advantage
58
Ontores Biotech
Tel
0571-88760729 18072970094
Email
supports@ontorespeptide.com
Country
China
ProdList
2696
Advantage
58
Hangzhou Go Top Peptide Biotech
Tel
15397062932
Email
sales1@gotopbio.com
Country
China
ProdList
2923
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
DONBOO AMINO ACID COMPANY
Tel
+8618051385538
Email
donboo@donboo.com
Country
China
ProdList
9363
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58
TCI (Shanghai) Chemical Trading Co., Ltd.
Tel
021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
29668
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
13675144456
Email
alan.chow@synzest.com
Country
China
ProdList
9470
Advantage
58
Guangzhou Weihua Biotechnology Co., Ltd
Tel
020-020-37239396 18922492046
Email
weihuasw@foxmail.com
Country
China
ProdList
4735
Advantage
58
Shaoxing Junyu Biotechnology Co., LTD
Tel
0571-0571-88211921 19105816207
Email
sales4@gotopbio.com
Country
China
ProdList
5144
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
Tel
0571-87213919 17306812703
Email
3007955328@qq.com
Country
China
ProdList
6979
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29784
Advantage
58
Hangzhou Baige Pharmaceutical Technology Co. , Ltd.
Tel
0571-85350119 15888826472
Email
15888826472@163.com
Country
China
ProdList
2729
Advantage
58
Shanghai HongTide Biotechnology Co.,Ltd.
Tel
15318089928
Email
alex@hanhonggroup.com
Country
China
ProdList
4604
Advantage
58
Henan Evonik Biotechnology Co. LTD
Tel
16650615803
Email
2224986086@qq.com
Country
China
ProdList
4754
Advantage
58
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd
Tel
13770887460
Email
wenxi@jszkhy.com
Country
China
ProdList
1354
Advantage
58
Combio (Suzhou) Ltd.
Tel
17751201929
Email
office@combiosz.com
Country
China
ProdList
3000
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29995
Advantage
58
Shandong Mopai Biotechnology Co., Ltd
Tel
13053322091
Email
admin@mopaikeji.com
Country
China
ProdList
5830
Advantage
58
Nanjing Yushengkang Biotechnology Co., Ltd
Tel
13327808530
Email
2670965693@qq.com
Country
China
ProdList
2179
Advantage
58
Zhejiang Jiekun Biotechnology Co., Ltd
Tel
0571-88211951 13735575465
Email
sales1@gotopbio.com
Country
China
ProdList
4880
Advantage
58
Taiyuan Bailihengkang Biotechnology Co., Ltd
Tel
19135651983
Email
18611134419@163.com
Country
China
ProdList
4416
Advantage
58
Hangzhou Bingochem Co., Ltd.
Tel
0571-8512-5372
Email
sales@bingochem.com
Country
China
ProdList
21669
Advantage
58
Baoji Didu Pharmaceutical and Chemical Co., Ltd
Tel
029-81145305 17791533577
Email
1021@dideu.com
Country
China
ProdList
10009
Advantage
58
Hangzhou Beiputai Biopharmaceutical Co., Ltd
Tel
0571-85350119 15888826472
Email
bptsales@163.com
Country
China
ProdList
3834
Advantage
58
Guangdong Wengjiang Chemical Reagent Co.,Ltd.
Tel
0751-2815983 13927872582
Fax
0751-2886750
Email
2787852318@qq.com
Country
China
ProdList
8083
Advantage
58
Hubei Danding Pharmaceutical Technology Co., Ltd
Tel
17701422019
Email
1559451077@qq.com
Country
China
ProdList
8163
Advantage
58
More
Less

View Lastest Price from H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH manufacturers

Career Henan Chemical Co
Product
H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH 143413-47-2
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-13

143413-47-2, H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OHRelated Search:

GO-203 TAT (48 - 57) K9 D-R9 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE LCKLSL HUWENTOXIN IV CALCIUM-LIKE PEPTIDE DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS COG-1410 HNGF6A PHRIXOTOXIN 3 GIP (1-39) H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH (ARG)9, TAMRA-LABELED (ARG)9, FAM-LABELED H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH H-ARG-ARG-ARG-ARG-OH

  • H-RRRRRRRRR-NH2
  • RRRRRRRRR
  • (ARG)9
  • H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH
  • Nonaarginine
  • H(-Arg)9-OH, Nonaarginine
  • (Arg)9 peptide
  • Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg
  • Poly Arginine 9|(Arg)9 peptide|RRRRRRRRR
  • Poly Arginine 9|(Arg)9 NJ-Peptide
  • Poly Arginine 9
  • L-Arginine,L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-
  • Nona-L-arginine
  • Peptide R9
  • L-Arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginine
  • R 9 peptide
  • (6S,9S,12S,15S,18S,21S,24S,27S,30S)-1,6-Diamino-9,12,15,18,21,24,27,30-octakis(3-guanidinopropyl)-1-imino-7,10,13,16,19,22,25,28-octaoxo-2,8,11,14,17,20,23,26,29-nonaazahentriacontan-31-oic acid
  • R9/Nonaarginine
  • 143413-47-2
  • C54H110N36O10
  • peptide