LCKLSL

Product Name: LCKLSL
CAS No.: 533902-29-3
Chemical Name: LCKLSL
Synonyms: LCKLSL;L-Leucine, L-leucyl-L-cysteinyl-L-lysyl-L-leucyl-L-seryl-
CBNumber: CB66224574
Molecular Formula: C30H57N7O8S
Formula Weight: 675.88
MOL File: 533902-29-3.mol

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LCKLSL Property

Boiling point:: 1024.2±65.0 °C(Predicted)
Density: 1.185±0.06 g/cm3(Predicted)
pka: 3.30±0.10(Predicted)
form: Solid
color: White to off-white
Sequence: Leu-Cys-Lys-Leu-Ser-Leu

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Hazard and Precautionary Statements (GHS)

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LCKLSL Chemical Properties,Usage,Production

Uses

LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles[1].

in vivo

Application of LCKLSL in two in vivo models (in chicken chorioallantoic membrane and murine Matrigel plug assays) of angiogenesis demonstrates suppression of the angiogenic responses. Treatment with the LCKLSL peptide significantly decreases the vascular length. At a dose of 5 μg/mL, the LCKLSL peptide significantly decreases the number of vascular branches, junctions and end-points^[1].

References

[1] Mallika Valapala, et al. A Competitive Hexapeptide Inhibitor of Annexin A2 Prevents Hypoxia-Induced Angiogenic Events. J Cell Sci. 2011 May 1;124(Pt 9):1453-64. DOI:10.1242/jcs.079236

LCKLSL Preparation Products And Raw materials

Raw materials

Preparation Products

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LCKLSL Suppliers

China 24 United States 2 Global 26

Shanghai Chaolan Chemical Technology Center

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Hangzhou Go Top Peptide Biotech

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Beijing Jin Ming Biotechnology Co., Ltd.

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533902-29-3, LCKLSLRelated Search:

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LCKLSL

L-Leucine, L-leucyl-L-cysteinyl-L-lysyl-L-leucyl-L-seryl-

533902-29-3