COG-1410

Product Name: COG-1410
CAS No.: 878009-24-6
Chemical Name: COG-1410
Synonyms: COG-1410;L-Leucinamide, N-acetyl-L-alanyl-L-seryl-2-methylalanyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-2-methylalanyl-L-lysyl-L-arginyl-L-leucyl-
CBNumber: CB38120864
Molecular Formula: C64H121N21O14
Formula Weight: 1408.78
MOL File: 878009-24-6.mol

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COG-1410 Property

Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C, protect from light, stored under nitrogen
solubility: DMSO : 100 mg/mL (70.98 mM; Need ultrasonic)
form: Solid
pka: 12.62±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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COG-1410 Chemical Properties,Usage,Production

Uses

COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease[1][2].

in vivo

COG1410 (0.3-0.6 mg/kg; a single i.v.) exhibits significant improvement on a short term test of vestibulomotor function and on a long term test of spatial learning and memory in mice^[1].
? COG1410 (0.8 mg/kg; a single i.v.) improves vestibulomotor function, decreases poststroke locomotor asymmetry, and decreases infarct volume of the ipsilateral hemisphere in rats^[2].

Animal Model:	Male C57Bl/6J mice (12-16 weeks) with TBI^[1]
Dosage:	0.3, 0.6 mg/kg
Administration:	A single i.v. by tail vein
Result:	Improved motor function on days 1-5 postinjury. Significantly improved cognitive impairment. Reduced the number of injured hippocampal neurons. Suppressed the microglial activation.

References

[1] Laskowitz DT, et, al. COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. J Neurotrauma. 2007 Jul;24(7):1093-107. DOI:10.1089/neu.2006.0192
[2] Tukhovskaya EA, et, al. COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia. J Neurosci Res. 2009 Feb 15;87(3):677-82. DOI:10.1002/jnr.21874
[3] Kuai L, et, al. Apolipoprotein E-Mimetic Peptide COG1410 Enhances Retinal Ganglion Cell Survival by Attenuating Inflammation and Apoptosis Following TONI. Front Neurosci. 2019 Sep 13;13:980. DOI:10.3389/fnins.2019.00980

COG-1410 Preparation Products And Raw materials

Raw materials

Preparation Products

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COG-1410 Suppliers

China 20 United States 2 Global 22

Hangzhou Peptidego Biotech Co.,Ltd.

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BOC Sciences

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Wuxi Helen Biotechnology Co., Ltd.,

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Nanjing Yuanpeptide Biotech Co.，Ltd.

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Hangzhou Baige Pharmaceutical Technology Co. , Ltd.

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878009-24-6, COG-1410Related Search:

Angiotensin II, 5-L-isoleucine-8-glycine- antibacterial protein ll-37 amide (human) PKA Inhibitor Fragment (6-22) amide LCKLSL 2-8-Angiotensin II, 2-glycine-5-L-isoleucine- CALCIUM-LIKE PEPTIDE Dentonin DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH HNGF6A -Defensin-2 (human) (trifluoroacetate salt) L-Glutamine, L-leucyl-L-lysyl-L-lysyl-L-threonyl-L-α-glutamyl-L-threonyl- L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide C-PEPTIDE 2 (RAT) H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH HUWENTOXIN IV GIP (1-39) PHRIXOTOXIN 3

COG-1410

L-Leucinamide, N-acetyl-L-alanyl-L-seryl-2-methylalanyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-2-methylalanyl-L-lysyl-L-arginyl-L-leucyl-

878009-24-6

C64H121N21O14