Angiotensin II, 5-L-isoleucine-8-glycine-

Product Name: Angiotensin II, 5-L-isoleucine-8-glycine-
CAS No.: 40678-47-5
Chemical Name: Angiotensin II, 5-L-isoleucine-8-glycine-
Synonyms: TRV120056;Angiotensin II, 5-L-isoleucine-8-glycine-
CBNumber: CB88383578
Molecular Formula: C43H65N13O12
Formula Weight: 956.07
MOL File: 40678-47-5.mol

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Angiotensin II, 5-L-isoleucine-8-glycine- Property

Density: 1.48±0.1 g/cm3(Predicted)
form: Solid
pka: 3.67±0.10(Predicted)
color: White to off-white
Sequence: Asp-Arg-Val-Tyr-Ile-His-Pro-Gly

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Hazard and Precautionary Statements (GHS)

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Angiotensin II, 5-L-isoleucine-8-glycine- Chemical Properties,Usage,Production

Uses

TRV120056 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein[1].

References

[1] Rajagopal S, et, al. Quantifying ligand bias at seven-transmembrane receptors. Mol Pharmacol. 2011 Sep;80(3):367-77. DOI:10.1124/mol.111.072801
[2] Strachan RT, et, al. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). J Biol Chem. 2014 May 16; 289(20): 14211-24. DOI:10.1074/jbc.M114.548131

Angiotensin II, 5-L-isoleucine-8-glycine- Preparation Products And Raw materials

Raw materials

Preparation Products

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Angiotensin II, 5-L-isoleucine-8-glycine- Suppliers

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40678-47-5, Angiotensin II, 5-L-isoleucine-8-glycine-Related Search:

antibacterial protein ll-37 amide (human) PKA Inhibitor Fragment (6-22) amide LCKLSL 2-8-Angiotensin II, 2-glycine-5-L-isoleucine- CALCIUM-LIKE PEPTIDE Dentonin DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS H-TYR-CYS-TRP-SER-GLN-TYR-LEU-CYS-TYR-OH COG-1410 HNGF6A -Defensin-2 (human) (trifluoroacetate salt) L-Glutamine, L-leucyl-L-lysyl-L-lysyl-L-threonyl-L-α-glutamyl-L-threonyl- L-Cysteine, L-cysteinylglycyl-L-asparaginyl-L-lysyl-L-arginyl-L-threonyl-L-arginylglycyl-, cyclic (1→9)-disulfide C-PEPTIDE 2 (RAT)

Angiotensin II, 5-L-isoleucine-8-glycine-

TRV120056

40678-47-5

C43H65N13O12